The results suggest that dental implant therapy can be offered to patients with well-controlled T2DM, as there were no significant differences between control and diabetic patients in terms of clinical parameters or GCF and PICF cytokine levels.

Objective: The aim of this study was to evaluate the amount of periodontal pathogens (Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans (Aa), Campylobacter rectus (Cr), Treponema denticola (Td)) in saliva, peri-implant subgingival plaque samples and from natural teeth closest to the implants in the type 2 diabetes patients Materials and Methods: Thirteen patients with well-controlled T2DM and seven systemically healthy patients were recruited for this study. A total of 39 dental implants; 27 implants in the diabetic group and 12 implants in the control group were placed. Subgingival plaque and saliva samples were collected from the implant and natural teeth at baseline and postoperatively at 1 month, 4 months, and 7 months. Real-time polymerase chain reaction (RT-PCR) was used in the microbiological analysis. Results: The amount of Td was found to be higher in the teeth and implants of the diabetes group than in the control group at follow-up times and the baseline value in the saliva was also higher in the diabetes group than in the control group. The Pg amounts at baseline and 7 months and the Cr amounts at baseline, 4 months, and 7 months were higher in the teeth of the control group than in the diabetes group. Pg amounts at baseline and 4 months and Cr amounts at 1 month were higher in the diabetes group than in the control group. The peri-implant amounts of Cr in the diabetes group at 1 month were higher than in the control group and its amounts were higher at 7months in the control group than in the diabetes group. The amounts of Aa around both the implant and the teeth did not differ between diabetes and control groups during the follow-up periods. Conclusions: According to the results of the study, although some periodontal pathogenic bacteria increased in both diabetes and control groups during the follow-up periods, no infection was detected around the implant in either group.

Aim:The aim of this study was to evaluate the effects of systemically-administered Coriandrum sativum L (CSL) and low dose doxycycline (LDD) on serum levels of antioxidant enzymes and intensity of inflammatory cells in rats with experimental periodontitis. Material and Methods: Forty adult male Wistar Albino rats were divided randomly into 5 groups as follows: group 1: periodontally healthy (control); group 2: periodontitis; group 3: periodontitis+CSL (32mg/kg); group 4: periodontitis+CSL (200mg/kg); group 5: periodontitis+LDD (6 mg/kg). Serum gingival superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) levels were evaluated by ELISA. The intensity of inflammatory cells were evaluated by histopathologically. Results: SOD levels were statistically lowest in group 1 and statistically were highest in group 2 than those of other groups. There was a statistical difference in SOD levels in paired comparisons of groups 1 and 2 with other groups. Its level did not have statistically significant among groups 3, 4 and 5. CAT levels were statistically lowest in group 2 than those of other groups, and no differences were reported among groups 1, 3, 4, and 5. GSH-Px levels did not have statistically significant among groups. Inflammatory cell infiltration was found to be statistically higher in groups 2 and 4 compared to group 1, and no statistical significance was reported among groups 1, 3, and 5. Conclusion: CSL and LDD application groups did not show differences in terms of serum SOD, serum CAT, and intensity of inflammatory cells. Therefore, we suggest that the different dosages of CSL should be examined in the treatment of periodontitis.

Amaç: Bu çalışmada sigara kullanımının yumuşak doku ogmentasyonunda alıcı saha olarak kullanılan palatal çiğneme mukozasındaki mikrosirkülasyona ve kalınlığa etkisinin değerlendirilmesi ve mukoza kalınlığı ile mikrosirkülasyon arasındaki ilişkinin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmamıza yaşları 28-48 arasında değişen sigara kullanan (n=16) ve kullanmayan (n=15) diş eti çekilmesi nedeniyle kliniğe başvurmuş olan hastalar dahil edildi. Bu hastalardaki palatal mukoza kalınlığı anterior ve posterior bölgede transgingival sondlama yöntemi ile kaydedildi. Mukozanın mikrokanlanması ise laser Doppler flowmetri (LDF) aracılığı ile siyanoakrilat ile sabitlenerek perfuzyon ünitesi (PU) cinsinden veriler kaydedildi. Verilerin istatistiksel analizleri bağımsız iki örnek t-testi veya Mann Whitney U testi ile yapıldı. Bulgular: Palatal mukoza kalınlığı ve LDF ölçümlerinin ortalaması sırasıyla anterior bölgede 3.5 mm ve 183 PU iken, posterior bölgede ise 2.7 mm ve 218 PU bulundu. Sigara kullanan hastalarda, kullanmayanlara göre perfüzyon ünit ve palatal mukoza kalınlıkları yönünden aralarında istatistiksel farklılık görülmedi. Palatal mukoza kalınlığının anteriorda posteriora göre istatistiksel olarak daha yüksek olduğu, LDF’nin ise daha düşük olduğu bulgulandı (p

Periodontal hastalıklar sonucunda ortaya çıkan defektleri iyileştirmek amacıyla ortaya konan çözümlerin yeterli olmaması sebebiyle; araştırmalar defekt bölgelerine uygulanabilecek yeni ajanlar geliştirmeye yönelmiştir. En umut verici çalışmaların Emdogain ve mineralizan peptitler kullanılarak yapıldığı görülmüştür. Bu derleme Emdogain ve mineralizan peptitlerin periodontal defektlere uygulanması ile oluşan sonuçları ve hangi bölgelerde kullanım alanları olduğunu inceleyen çalışmalardan oluşmaktadır.