Evaluation of Continuous Antibiotic Therapy in Chronic Bronchitis

Evolution of the Ventilatory Capacity in Chronic Bronchitis

“…In controlled trials of the prophylactic use of antibiotics the total period of disability from exacerbations has been found to be reduced but the number of exacerbations unaffected (Murdoch, Leckie, Downie, Swain, and Gould, 1959;Francis and Spicer, 1960 ;Francis, May and Spicer, 1964). This suggests that the acute exacerbations are initiated by factors unrelated to bacterial infection but may be prolonged by its secondary effects.…”

Beta-haemolytic streptococci in South-west Essex, with particular reference to tetracycline resistance.

“…The administration of antibiotics, particularly of tetracycline, in the prophylaxis of rheumatic fever in penicillin-allergic subjects has been advocated (Hodes, 1959), and long-term therapy with tetracycline for chronic bronchitis is effective just now (Murdoch et al, 1959 ;Francis et al, 1964). This widespread use of tetracycline for respiratory infections and a noticeable increase in the numbers of beta-haemolytic streptococci being isolated, many of which were tetracycline-resistant in vitro, prompted the present communication.…”

Viral Antibody Levels and Clinical Status in Acute Exacerbations of Chronic Bronchitis: a Controlled Prospective Study

“…Influenza A virus, particularly during epidemics and pandemics, has been shown to cause exacerbations often severe enough to require admission of the patient to hospital (Tyrrell, 1952;Stuart-Harris et al, 1953;Walker et al, 1958;Murdoch et al, 1959;Ross et al, 1966). Similarly influenza B virus and parainfluenza types 1 and 3 viruses may at times be associated with up to 7% of exacerbations (Stark et al, 1965).…”