Evaluation of CT perfusion parameters for assessment of split renal function in healthy donors

El-Diasty, M. T.; Gaballa, Ghada; Gad, Hossam M.; Borg, Mohamed A; Abou-Elghar, Mohamed; Sheir, Khaled Z.; El-Diasty, Tarek

doi:10.1016/j.ejrnm.2016.07.017

Cited by 10 publications

(17 citation statements)

References 36 publications

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“…Renal hypoperfusion and associated hypoxia are key elements in the pathophysiology of acute kidney injury and progression to chronic kidney diseases (2). Renal perfusion values are measured to evaluate renal function in human patients with unilateral ureteral obstruction, split renal function in kidney transplantation donors, and the hemodynamic significance of renal artery stenosis (3)(4)(5). Renal perfusion measurements are used to detect and differentiate the different types of renal tumors and to assess the efficacy of antiangiogenic tumor treatments (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

“…There are only few methods that can be used in the noninvasive evaluation of renal perfusion. These methods include contrast-enhanced ultrasound (CEUS), dynamic contrastenhanced magnetic resonance imaging, and isotopic renography (4,5,12,13). The absolute quantification of renal perfusion on contrast-enhanced magnetic resonance imaging is challenging to perform, because there is no linear relationship between signal intensity and the concentration of the contrast medium (12,13).…”

Section: Introductionmentioning

confidence: 99%

“…The absolute quantification of renal perfusion on contrast-enhanced magnetic resonance imaging is challenging to perform, because there is no linear relationship between signal intensity and the concentration of the contrast medium (12,13). Isotopic renography can evaluate split renal function however it has limitations, such as radiation exposure and high cost (4). CEUS can evaluate renal perfusion change reproducibly and is easily used in routine clinical practice in dogs and cats (8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

“…Computed tomography (CT) perfusion is based on temporal changes in tissue enhancement and analytic approaches including Patlak analysis, deconvolution, and maximum slope methods for computing perfusion values (14). CT perfusion is widely used in humans because it has better spatial resolution than magnetic resonance imaging or scintigraphy, and it facilitates the absolute quantification of renal perfusion based on the strict linear relationship between the measured renal tissue attenuation and the concentration of the contrast medium (4)(5)(6). Previous studies in pigs have demonstrated that CT perfusion values are significantly correlated with renal perfusion derived from fluorescent microspheres and that obtained using ultrasound flow probes (15,16).…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Renal Blood Flow Using Maximum Slope-Based Computed Tomography Perfusion and Ultrasound Flow Probe in Healthy Dogs

et al. 2020

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Computed tomography (CT) perfusion can analyze tissue perfusion and quantitative parameters, including blood flow, blood volume, and transit time. CT perfusion has been used for evaluating split renal function. However, its applicability in veterinary medicine was not validated. This study aimed to evaluate the correlation of renal blood flow (RBF) derived by maximum slope-based CT perfusion and an ultrasonic flow probe and assess the effect of the presence of a pre-existing contrast medium on CT perfusion in the kidneys. In five healthy purpose-bred beagles, CT perfusion was performed at the level of the left renal hila after injection of 1 mg/kg iohexol, during measuring RBF with an ultrasonic flow probe placed on the left renal artery. After post-contrast CT scan with injection of 2 mg/kg iohexol, CT perfusion scan was repeated with the same protocol used in the first perfusion study. The CT perfusion derived RBF was analyzed based on the maximum slope and was compared with the true RBF obtained using an ultrasonic flow probe. Results indicated that CT perfusion derived RBF was significantly correlated with true RBF, although CT perfusion derived RBF did not match the absolute value of the true RBF. It was correlated with the true RBF, even in the presence of a pre-existing contrast medium in the kidney. CT perfusion can estimate the change in individual renal perfusion non-invasively, and this method can be used supplementary to the conventional CT protocol in clinic.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of Renal Blood Flow Using Maximum Slope-Based Computed Tomography Perfusion and Ultrasound Flow Probe in Healthy Dogs

et al. 2020

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“…(Konrad-Zuse-Zentrum, Berlin) software was used to generate 3D CTmodels [6]. As it was demonstrated in the previous papers utilizing Amira software may aid for decision-making leading to less operative time, blood loss, warm ischemia time, length of hospital stay and negative surgical margins [1,3]. Currently, Amira is routinely used in a Research Institute for Uronephrology and Reproductive Health for preoperative decision-making.…”

mentioning

confidence: 99%

A New Approach for Split Renal Function Evaluation of Glomerular Filtration Rate, Perfusion and Plasma Flow by Numerical Analysis of 3d MSCT-Based Models

Alyaev¹,

Khokhlachev²,

Fiev³

et al. 2018

Rejr

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ntroduction. Instrumental methods of examination may alter the course of treatment and patients' management. Several studies have shown that interobserver variability in values obtained with renal scintigraphy (RS) can be as high as 10%, however, RS remains the standard investigation for the assessment of split renal function.Objective. This paper aims to present how numerical analysis of abdominal MSCT results can be used to evaluate split renal function.Materials and methods. A prospective study was launched in a Research Institute for Uronephrology and Reproductive Health from November, 2015 to May, 2017. 88 patients were enrolled into the study (2 with hydronephrosis, 10 with hypertensive kidney disease, 5 with stone kidney disease, 2 with kidney anomalies, 69 with renal tumors). Comparison made between renal scintigraphy data and 3D MSCT-based models. Results. CT-based methods for the calculation of split renal function with 3D-models showed correlation with renal scintigraphy (p<0.004).Conclusion. A new approach for split kidney function assessment based on contrast-enhanced CT with 3D-models and mathematical analysis allows for both acquiring detailed data on clinical anatomy and evaluation of renal function to promote preoperative decision-making. It showed strong correlation with no significant difference in comparison with RS in terms of glomerular filtration rate, perfusion and plasma flow.Keywords: 3D-models, MSCT, scintigraphy, split renal function assessment.Corresponding author: Iurova M.V., iurovamv@gmail.com. MSCT-based models. REJR 2018; 8(2):105-109. DOI:10.21569/2222 8(2):105-109. DOI:10.21569/ -7415-2018

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A prospective study of novel mathematical analysis of the contrast-enhanced computed tomography vs renal scintigraphy in renal function evaluation

Fiev

Proskura

Khokhlachev

et al. 2020

European Journal of Radiology

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Evaluation of CT perfusion parameters for assessment of split renal function in healthy donors

Cited by 10 publications

References 36 publications

Comparison of Renal Blood Flow Using Maximum Slope-Based Computed Tomography Perfusion and Ultrasound Flow Probe in Healthy Dogs

Comparison of Renal Blood Flow Using Maximum Slope-Based Computed Tomography Perfusion and Ultrasound Flow Probe in Healthy Dogs

A New Approach for Split Renal Function Evaluation of Glomerular Filtration Rate, Perfusion and Plasma Flow by Numerical Analysis of 3d MSCT-Based Models

A prospective study of novel mathematical analysis of the contrast-enhanced computed tomography vs renal scintigraphy in renal function evaluation

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