Evaluation of cutaneous angioimmunoblastic T-cell lymphoma

Balaraman, Brundha; Conley, Jarod A.; Sheinbein, David

doi:10.1016/j.jaad.2010.05.030

Cited by 44 publications

(63 citation statements)

References 50 publications

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“…15,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] Clinically, primary cutaneous CD4( þ ) small/ medium-sized pleomorphic T-cell lymphoma and angioimmunoblastic T-cell lymphoma present or may present with primary cutaneous involvement. 20,[36][37][38][39][40] Other CD4( þ ) T-cell lymphomas with primary cutaneous manifestations include mycosis fungoides and its variants including Sezary syndrome, adult T-cell leukemia/lymphoma and primary cutaneous CD30 þ lymphoproliferative disorders. 41 CD10 has not been reported to be a feature of mycosis fungoides or Sezary syndrome.…”

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confidence: 99%

“…20,34 Angioimmunoblastic T-cell lymphoma is an aggressive nodal-based disease that involves skin in roughly 50% of individuals. [38][39][40] The neoplastic T cells in angioimmunoblastic T-cell lymphoma express the follicular center helper T-cell markers CD10, PD-1, and CXCL-13 in the majority of cases. 27,[41][42][43] Angioimmunoblastic T-cell lymphoma is also notable for an association with EBV as 70% or more angioimmunoblastic T-cell lymphoma lesions contain EBV( þ ) B cells, a finding helpful in establishing the diagnosis.…”

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confidence: 99%

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Follicular center helper T-cell (TFH) marker positive mycosis fungoides/Sezary syndrome

et al. 2013

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confidence: 99%

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Follicular center helper T-cell (TFH) marker positive mycosis fungoides/Sezary syndrome

et al. 2013

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“…[21][22][23] It is also present in the majority of cases of early stage adult T-cell leukemia/lymphoma (ATLL) 31,32 and type B lymphomatoid papulosis (LYP). 16 However, epidermotropism is either absent or variably seen in other non-MF CTCLs included in WHO classification 14,15,[17][18][19][20][24][25][26][27][28][29][30]33 (Table 2). In 2 different studies, epidermotropism was absent in 60% and 79% of non-MF CTCL cases.…”

Section: Epidermotropismmentioning

confidence: 99%

Pitfalls in the Diagnosis of Cutaneous Lymphoma

Batrani

Bhawan

2014

The American Journal of Dermatopathology

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Cutaneous lymphomas are primarily classified as cutaneous T-cell/natural killer (NK) cell lymphomas and B-cell lymphomas; their classification being of utmost importance for prognostic and therapeutic purposes. Despite certain distinguishing attributes related to both these categories of lymphomas, considerable overlaps and deviations from the usual features exist and can lead to misclassification. The objective of this review is to discuss the various pitfalls involving morphology, immunohistochemistry, and gene rearrangement studies, all of which pose challenges in classifying cutaneous lymphomas as either the T-cell/natural killer cell or B-cell type.

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“…Skin rashes are associated with AITL in 50–80% of patients 2,10–17 . Typically, the rash is morbilliform, and less commonly purpuric, urticarial, nodular or petechial.…”

Section: Introductionmentioning

confidence: 99%

“…Typically, the rash is morbilliform, and less commonly purpuric, urticarial, nodular or petechial. Pruritus can be seen in up to 84% of cases 10 . It is now accepted that AITL derives from a population of regulatory T-cells, called follicular T-helper cells (T FH ), that express PD1, CD10, BCL6, and CXCL13 and whose normal function is to induce B-cell activation in the germinal center.…”

Section: Introductionmentioning

confidence: 99%

Extranodal Marginal Zone Lymphoma–like Presentations of Angioimmunoblastic T-Cell Lymphoma

Kaffenberger

Haverkos

Tyler

et al. 2015

The American Journal of Dermatopathology

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Angioimmunoblastic T-cell lymphoma (AITL) is the second most common type of peripheral T-cell lymphoma (PTCL) worldwide, and in some countries the most common form. Clinically, AITL usually presents with systemic symptoms, diffuse lymphadenopathy, hepatosplenomegaly and common laboratory abnormalities such as hypergammaglobulinemia. Skin rashes are seen in 50–80% of patients. AITL derives follicular T-helper cells (TFH), that express germinal center markes and produces hyperactivation of B-cell seen in AITL. Although the histologic features of AITL in the skin could be similar to pathologic findings present in lymph node biopsies, we present herein 2 cases of AITL with histologic and immunophenotypic features that were somewhat suggestive of extranodal marginal zone lymphoma (MALT).Caution is urged to exclude the possibility of a systemic T-cell lymphoma such as AITL in cutaneous and lymph node B-cell proliferations.

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Evaluation of cutaneous angioimmunoblastic T-cell lymphoma

Cited by 44 publications

References 50 publications

Follicular center helper T-cell (TFH) marker positive mycosis fungoides/Sezary syndrome

Follicular center helper T-cell (TFH) marker positive mycosis fungoides/Sezary syndrome

Pitfalls in the Diagnosis of Cutaneous Lymphoma

Extranodal Marginal Zone Lymphoma–like Presentations of Angioimmunoblastic T-Cell Lymphoma

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