Evaluation of cytotoxicity and antimicrobial activity of an injectable bone substitute of carrageenan and nano hydroxyapatite

Ocampo, Jazmín González; Bassous, Nicole; Orozco, Claudia Patricia Ossa; Webster, Thomas J.

doi:10.1002/jbm.a.36488

Cited by 22 publications

(10 citation statements)

References 53 publications

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“…CGs are applied in various pharmaceutical formulations, including tablets [ 106 , 108 ], suppositories [ 109 , 110 ], films [ 111 ], fast-dissolving inserts (FDIs) [ 63 ], beads [ 112 , 113 ], pellets [ 114 , 115 , 116 ], microparticles [ 117 , 118 , 119 ], nanoparticles [ 120 , 121 , 122 , 123 , 124 , 125 ], inhalable systems, injectables [ 126 ], and hydrogels [ 127 , 128 , 129 ]. In addition, recent studies have shown that CGs are promising candidates in tissue engineering, thanks to their similarity to native glycosaminoglycans [ 127 , 128 , 130 , 131 ].…”

Section: Carrageenan In Biomedical Applicationsmentioning

confidence: 99%

“…CGs have also been considered in the development of an injectable bone substitute (IBS) [ 126 , 131 ]. Based on CG and nanohydroxyapatite (nHA), the formulations that consisted of 1%, 1.5%, and 2.5% CG and 60% nHA were evaluated, in order to determine its interactions with human osteoblasts.…”

Section: Carrageenan In Biomedical Applicationsmentioning

confidence: 99%

“…Based on CG and nanohydroxyapatite (nHA), the formulations that consisted of 1%, 1.5%, and 2.5% CG and 60% nHA were evaluated, in order to determine its interactions with human osteoblasts. The results indicated a minimal degree of cytotoxicity, with a viability of more than 90% for all test samples, indicating that bone substitutes do not pose a toxic threat against human osteoblast cells, being effectively safe for bone cells [ 131 ].…”

Section: Carrageenan In Biomedical Applicationsmentioning

confidence: 99%

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Carrageenan: Drug Delivery Systems and Other Biomedical Applications

2020

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Marine resources are today a renewable source of various compounds, such as polysaccharides, that are used in the pharmaceutical, medical, cosmetic, and food fields. In recent years, considerable attention has been focused on carrageenan-based biomaterials due to their multifunctional qualities, including biodegradability, biocompatibility, and non-toxicity, in addition to bioactive attributes, such as their antiviral, antibacterial, antihyperlipidemic, anticoagulant, antioxidant, antitumor, and immunomodulating properties. They have been applied in pharmaceutical formulations as both their bioactive and physicochemical properties make them suitable biomaterials for drug delivery, and recently for the development of tissue engineering. This article provides a review of recent research on the various types of carrageenan-based biomedical and pharmaceutical applications.

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Section: Carrageenan In Biomedical Applicationsmentioning

confidence: 99%

Section: Carrageenan In Biomedical Applicationsmentioning

confidence: 99%

Section: Carrageenan In Biomedical Applicationsmentioning

confidence: 99%

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Carrageenan: Drug Delivery Systems and Other Biomedical Applications

2020

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“…The cytotoxicity of micrometer-sized AgNPs was minimized by immobilizing them in carrageenan gel retaining the antibacterial property [ 85 ]. A study based on an injectable composite of carrageenan and nanoscale hydroxyapatite as an injectable bone substitute showed good adhesion properties with no cytotoxicity in vitro, as shown in Figure 6 [ 116 ]. The nanocomposite also exhibited antibacterial effect indicating its potential to restrict biofilm formation.…”

Section: Reviewmentioning

confidence: 99%

“…(C) The nanocomposite shows osteoblast cytotoxicity tests in cell lines (L02 and L929). Adapted from [ 116 ], J. I. González Ocampo et al, “Evaluation of cytotoxicity and antimicrobial activity of an injectable bone substitute of carrageenan and nano hydroxyapatite”, J. Biomed. Mater.…”

Section: Reviewmentioning

confidence: 99%

The role of deep eutectic solvents and carrageenan in synthesizing biocompatible anisotropic metal nanoparticles

Das

Kumar

Rayavarapu

2021

Beilstein J. Nanotechnol.

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Plasmonic metal nanoparticles are widely used for many applications due to their unique optical and chemical properties. Over the past decade, anisotropic metal nanoparticles have been explored for imaging, sensing, and diagnostic applications. The variations and flexibility of tuning the size and shape of the metal nanoparticles at the nanoscale made them promising candidates for biomedical applications such as therapeutics, diagnostics, and drug delivery. However, safety and risk assessment of the nanomaterials for clinical purposes are yet to be made owing to their cytotoxicity. The toxicity concern is primarily due to the conventional synthesis route that involves surfactants as a structure-directing agent and as a capping agent for nanoparticles. Wet chemical methods employ toxic auxiliary chemicals. However, the approach yields monodispersed nanoparticles, an essential criterion for their intended application and a limitation of the green synthesis of nanoparticles using plant extracts. Several biocompatible counterparts such as polymers, lipids, and chitosan-based nanoparticles have been successfully used in the synthesis of safe nanomaterials, but there were issues regarding reproducibility and yield. Enzymatic degradation was one of the factors responsible for limiting the efficacy. Hence, it is necessary to develop a safer and nontoxic route towards synthesizing biocompatible nanomaterials while retaining morphology, high yield, and monodispersity. In this regard, deep eutectic solvents (DESs) and carrageenan as capping agent for nanoparticles can ensure the safety. Carrageenan has the potential to act as antibacterial and antiviral agent, and adds enhanced stability to the nanoparticles. This leads to a multidimensional approach for utilizing safe nanomaterials for advanced biomedical and clinical applications.

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N-(9-Fluorenylmethoxycarbonyl)-L-Phenylalanine/nano-hydroxyapatite hybrid supramolecular hydrogels as drug delivery vehicles with antibacterial property and cytocompatibility

Wan

Chen

et al. 2020

J Mater Sci: Mater Med

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Evaluation of cytotoxicity and antimicrobial activity of an injectable bone substitute of carrageenan and nano hydroxyapatite

Abstract: How to cite this article: González Ocampo JI, Bassous N, Ossa Orozco CP, Webster TJ. 2018. Evaluation of cytotoxicity and antimicrobial activity of an injectable bone substitute of carrageenan and nano hydroxyapatite. J Biomed Mater Res Part A

Cited by 22 publications

References 53 publications

Carrageenan: Drug Delivery Systems and Other Biomedical Applications

Carrageenan: Drug Delivery Systems and Other Biomedical Applications

The role of deep eutectic solvents and carrageenan in synthesizing biocompatible anisotropic metal nanoparticles

N-(9-Fluorenylmethoxycarbonyl)-L-Phenylalanine/nano-hydroxyapatite hybrid supramolecular hydrogels as drug delivery vehicles with antibacterial property and cytocompatibility

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