2013
DOI: 10.1016/j.jhazmat.2013.01.038
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Evaluation of cytotoxicity of polypyrrole nanoparticles synthesized by oxidative polymerization

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Cited by 125 publications
(65 citation statements)
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“…Ramanavicius and co‐workers have reported detailed investigations of the toxicity of nanoparticles composed of the poly­electrolyte complex formed by polypyrrole and poly­styrenesulfonate . While high concentrations were toxic to primary mouse embryonic fibroblasts, mouse hepatoma (MH‐22A) cells, and human T lymphocyte Jurkat cells, affecting both cell viability and proliferation, this effect was dependent on the concentration of nanoparticles, and concentrations lower than 9.7 μg mL −1 did not affect cell viability or proliferation . Further, preclinical trials of such nanoparticles in mice carried out by the same group have shown that the nanoparticles did not display any detectable cytotoxicity toward mouse peritoneum cells, nor did they induce an allergic response, or affect spleen, kidney, or liver indexes .…”
Section: Resultsmentioning
confidence: 99%
“…Ramanavicius and co‐workers have reported detailed investigations of the toxicity of nanoparticles composed of the poly­electrolyte complex formed by polypyrrole and poly­styrenesulfonate . While high concentrations were toxic to primary mouse embryonic fibroblasts, mouse hepatoma (MH‐22A) cells, and human T lymphocyte Jurkat cells, affecting both cell viability and proliferation, this effect was dependent on the concentration of nanoparticles, and concentrations lower than 9.7 μg mL −1 did not affect cell viability or proliferation . Further, preclinical trials of such nanoparticles in mice carried out by the same group have shown that the nanoparticles did not display any detectable cytotoxicity toward mouse peritoneum cells, nor did they induce an allergic response, or affect spleen, kidney, or liver indexes .…”
Section: Resultsmentioning
confidence: 99%
“…Hydroxylamine was utilised by Wang et al in the preparation of their multimodal magnetic [21]. Polypyrrole (PPY) is a conductive polymer that has been demonstrated to induce photothermal effects, and is already widely used in many biomedical applications [22,23]. The core gold nanorods were synthesised using a modified seed mediated approach in which gold seeds synthesised using NaBH 4 and chloroauric acid in CTAB (hexadecyltrimethylammonium bromide), and a growth solution of AgNO 3 , HAuCl 4 and ascorbic acid.…”
Section: Synthesis Of Core/polymer/shell Magnetic-plasmonic Nanopartimentioning
confidence: 99%
“…The biocompatibility of ICPs has been extensively investigated both in vitro and in vivo. The reported results indeed demonstrated that the ICPs, especially PPy and poly(3,4-ethylenedioxythiophene) (PEDOT), possessed good biocompatibilities with cells, tissues, and organs [18][19][20][21][22][23]. Vaitkuviene et al showed that the PPy nanoparticles synthesized by oxidative polymerization exhibited almost no cytotoxicity to the primary mouse embryonic fibroblasts, mouse hepatoma cell line, and human T lymphocyte Jurkat cell line at low concentrations (up to 9.7 μg mL -1 ) [19].…”
Section: Introductionmentioning
confidence: 88%