Evaluation of desmethylmisonidazole-induced neurotoxicity in the rat using brainstem auditory evoked potentials

Edwards, Michael S. B.; Gordon, Deborah G.; Levin, Victor A.

doi:10.1016/0360-3016(84)90352-3

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…Moreover, ABR is applied in basic animal research to study age-related auditory changes, investigate the effect of therapeutic drugs on auditory potentials, and determine the mechanisms of diseases affecting the auditory system [21,22]. In rats, wave I of ABR associates with the activity of the peripheral auditory nerve.…”

Section: Introductionmentioning

confidence: 99%

Auditory Brainstem Responses (ABR) of Rats during Experimentally Induced Tinnitus: Literature Review

Domarecka

Szczepek

2020

Brain Sciences

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Tinnitus is a subjective phantom sound perceived only by the affected person and a symptom of various auditory and non-auditory conditions. The majority of methods used in clinical and basic research for tinnitus diagnosis are subjective. To better understand tinnitus-associated changes in the auditory system, an objective technique measuring auditory sensitivity—the auditory brainstem responses (ABR)—has been suggested. Therefore, the present review aimed to summarize ABR’s features in a rat model during experimentally induced tinnitus. PubMed, Web of Science, Science Direct, and Scopus databanks were searched using Medical Subject Heading (MeSH) terms: auditory brainstem response, tinnitus, rat. The search identified 344 articles, and 36 of them were selected for the full-text analyses. The experimental protocols and results were evaluated, and the gained knowledge was synthesized. A high level of heterogeneity between the studies was found regarding all assessed areas. The most consistent finding of all studies was a reduction in the ABR wave I amplitude following exposure to noise and salicylate. Simultaneously, animals with salicylate-induced but not noise-induced tinnitus had an increased amplitude of wave IV. Furthermore, the present study identified a need to develop a consensus experimental ABR protocol applied in future tinnitus studies using the rat model.

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Section: Introductionmentioning

confidence: 99%

Auditory Brainstem Responses (ABR) of Rats during Experimentally Induced Tinnitus: Literature Review

Domarecka

Szczepek

2020

Brain Sciences

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Alteration of brainstem auditory evoked potentials in diethylbenzene and diacetylbenzene‐treated rats

Gagnaire

Becker

Céaurriz

1992

J of Applied Toxicology

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Male Sprague-Dawley rats were treated either with 1,2-diethylbenzene (1,2-DEB) or its putative active metabolite, 1,2-diacetylbenzene (1,2-DAB). Experimental rats and appropriate controls were examined electrophysiologically for brainstem auditory evoked potentials (BAEP). Oral administration of 1,2-DEB (75 or 100 mg kg-1 once a day, 4 days a week, for 8 weeks) and intraperitoneal injection of 1,2-DAB (10 or 15 mg kg-1 once a day, 4 days a week, for 8 weeks) produced time- and dose-dependent increases in the peak latencies of all BAEP components as well as in interpeak (I-V) differences, and a decrease in the amplitudes of all the components. The absolute and interpeak latencies recovered partially during an 8-week (1,2-DEB) or a 10-week (1,2-DAB) recovery period, whereas there were long-lasting decreases in peak amplitudes.

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Evaluation of SR-2508 induced neurotoxicity and myotoxicity in rats using brainstem auditory evoked potentials and the posterior auricular muscle response

Gordon¹,

Edwards²

1985

International Journal of Radiation Oncology*Biology*Physics

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Evaluation of desmethylmisonidazole-induced neurotoxicity in the rat using brainstem auditory evoked potentials

Cited by 3 publications

References 6 publications

Auditory Brainstem Responses (ABR) of Rats during Experimentally Induced Tinnitus: Literature Review

Auditory Brainstem Responses (ABR) of Rats during Experimentally Induced Tinnitus: Literature Review

Alteration of brainstem auditory evoked potentials in diethylbenzene and diacetylbenzene‐treated rats

Evaluation of SR-2508 induced neurotoxicity and myotoxicity in rats using brainstem auditory evoked potentials and the posterior auricular muscle response

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