Evaluation of Dietary Habits in the Study of Pancreatic Cancer

Azeem, Kateřina; Horáková, D; Tomášková, Hana; Procházka,; Shonová, Olga; Martínek, Arnošt; Kyselý, Zdeněk; Janout,; Kollárová, Helena

doi:10.14735/amko2016196

Cited by 7 publications

(8 citation statements)

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“…A number of previous studies indicated that dietary habits, lifestyle (e.g. smoking and drinking et al ), oxidative and carbonyl stresses, and estrogens might play important roles in carcinogenesis [ 25 – 30 ]. In vivo , there are many antioxidant enzyme which may prevent genotoxic damage.…”

Section: Discussionmentioning

confidence: 99%

Association between Paraoxonase 1 polymorphisms and risk of esophagogastric junction adenocarcinoma: a case-control study involving 2,740 subjects

Tang

Liu

Wang³

et al. 2017

Oncotarget

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Esophagogastric junction adenocarcinoma (EGJA) is a serious public health problem with high mortality in China. In this study, we assessed the association between Paraoxonase 1 (PON-1) rs662 C>T, rs854560 A>T polymorphisms and EGJA risk. This case-control study enrolled 2,740 participants of Asians origin from the Eastern Chinese Han populations. SNPscanTM genotyping assay was harnessed to determine the genotyping of PON1 polymorphisms. The PON-1 rs854560 A>T and rs662 C>T genotypes distribution accorded with Hardy-Weinberg equilibrium. We found that there was no difference in the frequency of PON-1 rs662 C>T, rs854560 A>T genotypes between the overall EGJA cases and controls. In the subgroup analyses, the results indicated that PON-1 rs662 C>T polymorphism might be associated with a significantly decreased risk of EGJA in ever smoking group (TT vs. CC/CT: adjusted OR = 0.58, 95% CI 0.35-0.95, P = 0.029). In conclusion, our study highlights PON-1 rs662 C>T polymorphism may decrease the risk of EGJA, which interacts with the tobacco using. In the future, a fine-mapping case-control study with detailed geneenvironmental data is needed to further assess these potential relationship.

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Section: Discussionmentioning

confidence: 99%

Association between Paraoxonase 1 polymorphisms and risk of esophagogastric junction adenocarcinoma: a case-control study involving 2,740 subjects

Tang

Liu

Wang³

et al. 2017

Oncotarget

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“…Of the 49 studies included (Table 1), 16 were cohort studies [37,38,43,[55][56][57][58][59][60][61][62][63][64][65][66][67] (n = 1,512,760 individuals), and 33 were case-control studies [39][40][41][42]44,45, (n = 18,522 cases and 24,926 controls; n = 43,448 individuals). The association between broccoli consumption and cancer risk was meta-analyzed in 12 cohort studies [37,38,43,[55][56][57]59,[62][63][64][65][66] (n = 699,482 individuals) and 23 case-control studies [39][40][41][42]44,45,[68][69][70][71][72][73][74][75]…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…These data suggest biological plausibility that would explain and reinforce the possible benefits of broccoli consumption in cancer prevention. Some studies reported positive associations between broccoli consumption and risk in several types of cancer [ 37 , 38 , 39 , 40 , 41 , 42 ]; however, not all studies were consistent [ 43 , 44 , 45 ]. To our knowledge, there is no updated systematic review on this topic that includes all types of relevant studies and evaluates broccoli consumption associated with cancer risk.…”

Section: Introductionmentioning

confidence: 99%

Broccoli Consumption and Risk of Cancer: An Updated Systematic Review and Meta-Analysis of Observational Studies

Baladia,

Moñino,

Pleguezuelos

et al. 2024

Nutrients

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Background: The scientific literature has reported an inverse association between broccoli consumption and the risk of suffering from several types of cancer; however, the results were not entirely consistent across studies. A systematic review and meta-analysis of observational studies were conducted to determine the association between broccoli consumption and cancer risk with the aim of clarifying the beneficial biological effects of broccoli consumption on cancer. Methods: PubMed/MEDLINE, Web of Science, Scopus, Cochrane Library (CENTRAL), and Epistemonikos databases were searched to identify all published papers that evaluate the impact of broccoli consumption on the risk of cancer. Citation chasing of included studies was conducted as a complementary search strategy. The risk of bias in individual studies was assessed using the Newcastle-Ottawa Scale. A random-effects model meta-analysis was employed to quantitatively synthesize results, with the I2 index used to assess heterogeneity. Results: Twenty-three case–control studies (n = 12,929 cases and 18,363 controls; n = 31,292 individuals) and 12 cohort studies (n = 699,482 individuals) were included in the meta-analysis. The results suggest an inverse association between broccoli consumption and the risk of cancer both in case–control studies (OR: 0.64, 95% CI from 0.58 to 0.70, p < 0.001; Q = 35.97, p = 0.072, I2 = 30.49%—moderate heterogeneity; τ2 = 0.016) and cohort studies (RR: 0.89, 95% CI from 0.82 to 0.96, p = 0.003; Q = 13.51, p = 0.333, I2 = 11.21%—low heterogeneity; τ2 = 0.002). Subgroup analysis suggested a potential benefit of broccoli consumption in site-specific cancers only in case–control studies. Conclusions: In summary, the findings indicate that individuals suffering from some type of cancer consumed less broccoli, suggesting a protective biological effect of broccoli on cancer. More studies, especially cohort studies, are necessary to clarify the possible beneficial effect of broccoli on several types of cancer.

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“…A case-control study in the Czech Republic, found that a high consumption of citrus fruit as well as more than three portions of cooked vegetables per week had significant protective effects against pancreatic cancer [40]. Additional case-control studies completed in China and Italy observed a direct inverse relationship between vegetable consumption and pancreatic cancer [36,41].…”

Section: Evidence Linking Dietary Intake To the Pathogenesis Of Pamentioning

confidence: 99%

“…Other studies have associated the protective effect with relationship to diallyl disulfide and sulforaphone (present in cruciferous and Allium vegetables) to have the ability to inhibit histone deacetylase (HDACs) enzymes [44,45]. Evidence has shown these dietary components inhibit cell proliferation and stimulate apoptosis [40]. In addition, isothicyanates, an enzymatic product of a plant enzyme called myrosinase, has been shown in laboratory studies to inhibit the growth of human pancreatic cancer cell lines [27,44,46].…”

Section: Evidence Linking Dietary Intake To the Pathogenesis Of Pamentioning

confidence: 99%

Nutrients and the Pancreas: An Epigenetic Perspective

Weisbeck

Jansen

2017

Nutrients

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Pancreatic cancer is the fourth most common cause of cancer-related deaths with a dismal average five-year survival rate of six percent. Substitutional progress has been made in understanding how pancreatic cancer develops and progresses. Evidence is mounting which demonstrates that diet and nutrition are key factors in carcinogenesis. In particular, diets low in folate and high in fruits, vegetables, red/processed meat, and saturated fat have been identified as pancreatic cancer risk factors with a proposed mechanism involving epigenetic modifications or gene regulation. We review the current literature assessing the correlation between diet, epigenetics, and pancreatic cancer.

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Evaluation of Dietary Habits in the Study of Pancreatic Cancer

Cited by 7 publications

References 0 publications

Association between Paraoxonase 1 polymorphisms and risk of esophagogastric junction adenocarcinoma: a case-control study involving 2,740 subjects

Association between Paraoxonase 1 polymorphisms and risk of esophagogastric junction adenocarcinoma: a case-control study involving 2,740 subjects

Broccoli Consumption and Risk of Cancer: An Updated Systematic Review and Meta-Analysis of Observational Studies

Nutrients and the Pancreas: An Epigenetic Perspective

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