The study aimed at assessing the potential use of lower total and HMW adiponectin levels for predicting cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). Concentrations of total adiponectin or high molecular weight (HMW) adiponectin decrease in association with the development of metabolic dysfunction such as obesity, insulin resistance, or T2DM. Increased adiponectin levels are associated with a lower risk for coronary heart disease. A total of 551 individuals were assessed. The first group comprised metabolically healthy participants (143 females, and 126 males) and the second group were T2DM patients (164 females, and 118 males). Both total adiponectin and HMW adiponectin in diabetic patients were significantly lower when compared with the group of metabolically healthy individuals. There was a weak monotonic correlation between HMW adiponectin levels and triglycerides levels. Binary logistic regression analysis, gender adjusted, showed a higher cardiovascular risk in diabetic persons when both total adiponectin (OR = 1.700) and HMW adiponectin (OR = 2.785) levels were decreased. A decrease in total adiponectin levels as well as a decrease in its HMW adiponectin is associated with a higher cardiovascular risk in individuals with T2DM. This association suggests that adiponectin levels may be potentially used as an epidemiological marker for cardiovascular risk in diabetic patients.

Abstract:Objectives: The objective of the study was to analyze an association between selected factors and pancreatic cancer, assuming that knowing the etiology would help infl uence the incidence of this severe type of cancer through primary prevention. In addition to age, gender, BMI and education, the analysis aimed at assessing occupational and leisure-time physical activities with respect to pancreatic cancer. Background: In numerous studies, physical activity is reported to be a protective factor against pancreatic cancer. Methods: A case-control study was carried out in three centers in the Czech Republic in 2006-2009. Results: The study comprised a total of 529 individuals, of which 309 were patients with pancreatic cancer and 220 were controls. Leisure-time physical activity showed a statistically signifi cant inverse association with a crude odds ratio of 0.65 (95% CI 0.45-0.93), even after adjustment for other studied factors (OR =0.63, 95% CI 0.43-0.92). Conversely, for occupational physical activity, a positive association was only suggested. Conclusions: Leisure-time physical activity is a protective factor against the development of pancreatic cancer. Occupational physical activity was not confi rmed as a protective factor against pancreatic cancer (Tab. 4, Fig. 1, Ref. 22). Text in PDF www.elis.sk.

The relatively high incidence of insulin resistance in obese children without MS questions the prevailing diagnostic criteria of, perhaps, falsely excluding some cases of, MS.

Aims.A review of recent knowledge on heredital syndromes related to renal cell carcinoma. Methods. Aim of this review was to summarize the recent knowledge of genetic syndromes associated with renal cell carcinoma.Results. Summary of incidence and factors modulating risk of hereditary renal cell carcinoma development.

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