Evaluation of disease activity indices in Korean patients with rheumatoid arthritis

Abstract

The aim of this study is to examine the validity of the rheumatoid arthritis (RA), disease activity score (DAS), 28-C-reactive protein (CRP), the simplified disease activity index (SDAI), and the clinical disease activity index (CDAI) against the DAS28-erythrocyte sedimentation rate (ESR) and determine cut-off values for each tool in Korean patients with RA. A total of 223 RA patients were consecutively recruited from the Hanyang University Hospital for Rheumatic Diseases in Seoul, Korea. DAS28-CRP, SDAI, and CDAI were measured and compared with DAS28-ESR. The correlation coefficients of DAS28-ESR with DAS28-CRP, SDAI, and CDAI were 0.93, 0.85, and 0.84, demonstrating strong linear relationships. The cut-off values of DAS28-CRP classifying RA patients into four categories of disease activity were defined as 2.19, 2.60, and 4.07. SDAI cut-off values were defined as 3.75, 7.50, and 16.88. CDAI cut-off values were defined as 3.62, 7.38, and 16.50. DAS28-CRP, SDAI, and CDAI are valid and sensitive assessment indices of disease activity that are comparable to DAS28-ESR. The cut-off values of each tool derived in this study might be useful for routine monitoring and therapeutic decision-making in Korean RA patients.

Concordance and correlation of activity indices in patients with rheumatoid arthritis in northwestern Colombia: A cross‐sectional study

“…In our study, the cut‐off point for defining remission was increased in order to optimize results of the clinimetric indices; the literature tends to diminish cut‐off points, probably because the populations included in previous studies correspond to individuals with RA with predominantly high or moderate heterogeneous activity, as opposed to our population which was in remission or low activity. The other likely explanation is that the number of painful joints in our study is greater than in the populations published that are classified in remission; the painful joint count, ultimately, has a very important role in the equation of the clinimetric indices and substantially modifies the final result …”

Performances of Clinical Disease Activity Index (CDAI) and Simplified Disease Activity Index (SDAI) appear to be better than the gold standard Disease Assessment Score (DAS‐28‐CRP) to assess rheumatoid arthritis patients

“…SDAI and CDAI have been validated in a number of studies from the west . While SDAI and CDAI have been validated individually in Indian patients, there is just one study which has compared both and has found good correlation with DAS‐28 .…”

Importance of Disease Activity Indices in Indian Rheumatoid Arthritis (RA) Patients of Western Region

“…This result suggests that DAS 28-CRP can be used as an alternative to DAS28-ESR. SDAI and CDAI are simple, effective measurements of disease activity in rheumatoid arthritis and are significantly correlated with DAS28 [23]. SDAI is easy to calculate and is a viable tool for day-today clinical assessments.…”