The study shows an excellent strong positive correlation between DAS-28-CRP, CDAI and SDAI at initial evaluation but not at final visit. SDAI- and CDAI-based remission criteria seem to be better than DAS-28-CRP-based remission criteria.

With better care and intensive insulin therapy, microvascular complications have reduced and longevity has increased in patients with type 1 diabetes (T1DM). Therefore, there is a need to change the focus from microvascular complications to cardiovascular disease and osteoporosis. Though number of studies from other parts of the world show that patients with T1DM are at increased risk of osteoporosis and fractures, there is a paucity of data from India. A number of factors and mechanisms affecting bone health in patients with T1DM have been proposed. The main defect in genesis of osteoporosis is osteoblastic function, rather than osteoclastic overfunction. Assessment of bone mineral density by dual X-ray absorptiometry and other risk factors for osteoporosis, as a part of diagnostic procedure can help to design tailored treatment plans. A physically active healthy lifestyle, prevention of diabetic complications and adequate calcium and vitamin D supplementation are the mainstay for prevention of osteoporosis. Treatment of osteoporosis is not evidence based but it is proposed to be similar to osteoporosis associated with other conditions. Bisphosphonates are the mainstay for treatment of osteoporosis in patients with T1DM. However, more studies are needed to make definitive guidelines on prevention and treatment of osteoporosis in patients with T1DM.

Oral split doses of MTX are better than an oral single dose and similar to parenteral MTX in terms of efficacy.

Aims: Poisoning is a medical emergency associated with significant morbidity and mortality. This study was done to analyse the pattern of poisoning cases coming to our tertiary care centre located in the north eastern part of U.P., India. It is important to know the pattern of poisoning in a region so as to take proper actions for prevention and management of the cases. Methods: This was a retrospective hospital record based study of poisoning patients who were admitted to our tertiary care hospital between July, 2014 to December 2015. Data of total 140 cases were analyzed for demography, type of poisoning and outcome and results were analyzed statistically. Results: Pesticides dominated the picture amongst the rural population while urban people consumed drugs and household agents. The overall mortality rate was 4.28%. Most of the deaths were in Aluminium phosphide cases (66.66%) followed by paraquat and organochlorine. Conclusion: In adults poisoning is mostly suicidal while children accidentally ingest substances. Pesticides, chemicals and drugs available in house are mostly used. Rural people resort to pesticides while urban population takes household articles or drugs for self harm. Mortality depends on the type of poison, amount consumed and the time lapsed in reaching a health care facility as well as how equipped is the health care facility to tackle the poisoning cases.

MSK pain is a predominant health problem of both rural and urban areas. Sex-adjusted prevalence is higher among females than males. Knee and back were highly prevalent pain sites in both rural and urban areas of Lucknow.