Evaluation of Dynamic Disulphide/Thiol Homeostasis in Silica Exposed Workers

Gündüzöz, Meşide; Bal, Ceylan; Büyükşekerci, Murat; Neşeli̇oğlu, Salim; Öziş, Türkan Nadir; İritaş, Servet Birgin; Erel, Özcan

doi:10.4274/balkanmedj.2015.1632

Cited by 8 publications

(13 citation statements)

References 31 publications

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“…Solak et al [30] revealed that thiol/disulphide homeostasis shifts through disulphide side in oxidative stress of smokers. Similar findings have been obtained in silica-exposed workers, along with high serum disulphide level which is biomarker of oxidative stress [19].…”

Section: Thiol Resultssupporting

confidence: 84%

“…Recently studies have shown that the thiol/disulphide homeostasis is disturbed in lung diseases such as obstructive sleep apnea syndrome [17], COPD [26], asthma [26], silicasis [19], infectious pneumonia [27], pulmonary thromboembolism [28]. Dinc et al [16] declared that the SH level and %SH/total thiol ratio are low in patients with obstructive sleep apnea syndrome.…”

Section: Thiol Resultsmentioning

confidence: 99%

“…The gauging of dynamic thiol disulphide homeostasis is revealed valuable notice on normal physiologic or abnormal pathogenic conditions. Recent clinical studies have shown that the dynamic thiol disulphide homeostasis is disturbed in the respiratory abnormalities and lung diseases such as apnea, COPD and in healthy or unhealthy smokers and workers exposed to several particules or gases [16][17][18][19][20]. Therefore the dynamic thiol disulphide homeostasis status can play critical roles in antioxidant protection, detoxification, signal transduction, apoptosis, regulation of enzymatic activity and transcription factors and cellular signalling mechanisms in the BLM-induced fibrosis.…”

Section: Introductionmentioning

confidence: 99%

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Alterations in Thiol/disulphide Homeostasis of Acute Lung Toxicity of Bleomycin in Rats

Parlar¹,

Arslan²,

Doğan³

et al. 2019

Chem Pharm Res

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Bleomycin (BLM)-induced pulmonary fibrosis, a progressive and lethal form of interstitial lung disease, is mediated through the generation of reactive oxygen species. Since the dynamic thiol/disulphide homeostasis is a substantial marker for oxidative stress, for future glutathione based methodological researches on the progressive BLM toxicity in lungs, it is very valuable to show that the toxic mechanism.We investigated the dynamic thiol/disulphide homeostasis in a rat model with BLM-induced pulmonary fibrosis. BLM (5 mg/kg) or saline was injected into the lungs as 0,1 ml by insuline syringe that inserted into gently opened trachea of anesthetized rats.Native thiol (SH), total thiol (total SH), and disulphide (SS) levels were measured in rat serum at pre-treatment, 24th hour, 2nd, 4th, 7th, 14th, and 28th days of BLM treatment, with a novel automated method recently described.The levels of native SH and total SH in BLM group were decreased at 24th hour and this reduction were gradually continued up to 28th day when compared with pre-treatment BLM and/or the saline control group. On the other hand there were significantly a high ratio in BLM group with %SS/SH at 4th day and %SS/total SH at 4th and 28th days while there was no difference at 7th and 14th days.Results clearly indicate that the thiol/disulphide homeostasis can be acutely disturbed in the experimental model of BLM-induced fibrosis. So this data offer a new modeling option to discuss the therapy strategies and the effect mechanisms of BLM-induced lung toxicity.

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Section: Thiol Resultssupporting

confidence: 84%

Section: Thiol Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Alterations in Thiol/disulphide Homeostasis of Acute Lung Toxicity of Bleomycin in Rats

Parlar¹,

Arslan²,

Doğan³

et al. 2019

Chem Pharm Res

View full text Add to dashboard Cite

show abstract

“…Topuz et al detected that serum thiol levels in acute pulmonary thromboembolism (APE) patients were significantly low compared to a control group and disulfide level and disulfide/total thiol ratio were higher in APE group than control group [31]. Recent studies have shown that the thiol/disulphide homeostasis is disturbed in lung diseases such as infectious pneumonia [32], obstructive sleep apnea syndrome [33], COPD, asthma [34] and silicasis [35]. Plasma total thiol levels are reduced in patients with COPD or asthma [36].…”

Section: Discussionmentioning

confidence: 99%

Thiol -- Disulphide Homeostasis as a Novel Oxidative Stress Marker in Lung Tuberculosis Patient

Demir

Giden

Sak

et al. 2020

Preprint

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Aims of Study: To compare dynamic thiol/disulfide homeostasis between patients with with lung tuberculosis and healthy controls. Methods: Our study included 50 patients with active lung tuberculosis and 50 healthy controls. Serum thiol/disulfide was measured with a new automated spectrometric method developed by Erel and Neselioglu, and results were compared statistically. Results: We found that native and total thiol levels were significantly decreased in patients with lung tuberculosis, disulfide/native thiol and disulfide/total thiol levels were found to be higher in lung tuberculosis patients when compared with the control group. However, disulfide levels were higher in the control group than in the patient group. Conclusions: Based on the results of this study, it can be said that oxidative stress is closely associated with lung tuberculosis pathogenesis. There is a need for new studies that will show the possible effects of oxidative stress on lung tuberculosis pathogenesis.

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“…F I G U R E 4 Native thiol/Total thiol ratio between groups disulphide homoeostasis is disturbed in lung diseases such as infectious pneumonia, 32 obstructive sleep apnoea syndrome, 33 COPD, asthma 34 and silicosis. 35 Plasma total thiol levels are reduced in patients with COPD or asthma. 36 Solak et al have found native thiol and total thiol levels significantly lower in smokers in comparison with the control group.…”

Section: F I G U R E 3 Disulphide Levels Between Groupsmentioning

confidence: 99%

Thiol‐disulphide homoeostasis as a novel oxidative stress biomarker in lung tuberculosis patient

Demir

Giden

Sak

et al. 2021

Int. J. Clin. Pract.

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Aims of Study:To compare a novel oxidative stress biomarker dynamic thiol/disulphide homoeostasis between patients with lung tuberculosis and healthy controls.Methods: Our study included 50 patients with active lung tuberculosis and 50 healthy controls. Serum thiol/disulphide was measured with a new automated spectrometric method developed and results were compared statistically. Results:We found that native and total thiol levels were significantly decreased in patients with lung tuberculosis, disulphide/native thiol and disulphide/total thiol levels were found to be higher in lung tuberculosis patients when compared with the control group. However, disulphide levels were higher in the control group than in the patient group. Conclusions:Based on the results of this study, it can be said that oxidative stress is closely associated with lung tuberculosis pathogenesis. There is a need for new studies that will show the possible effects of oxidative stress on lung tuberculosis pathogenesis.

show abstract

Evaluation of Dynamic Disulphide/Thiol Homeostasis in Silica Exposed Workers

Cited by 8 publications

References 31 publications

Alterations in Thiol/disulphide Homeostasis of Acute Lung Toxicity of Bleomycin in Rats

Alterations in Thiol/disulphide Homeostasis of Acute Lung Toxicity of Bleomycin in Rats

Thiol -- Disulphide Homeostasis as a Novel Oxidative Stress Marker in Lung Tuberculosis Patient

Thiol‐disulphide homoeostasis as a novel oxidative stress biomarker in lung tuberculosis patient

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