Analysis of serum thiol levels and SH/SS homeostasis might be useful in order to determine the head trauma in pediatric patients.

Our study results suggest that thiol-disulphide homeostasis is disrupted in patients sustaining gunshot injuries, and thiol levels decrease in correlation with the severity of trauma with a high sensitivity and specificity. As the level of native thiol is an independent predictor of the severity of trauma, reduced thiol levels may be of prognostic value in the early assessment of patients in the emergency room.

Aims of Study:To compare a novel oxidative stress biomarker dynamic thiol/disulphide homoeostasis between patients with lung tuberculosis and healthy controls.Methods: Our study included 50 patients with active lung tuberculosis and 50 healthy controls. Serum thiol/disulphide was measured with a new automated spectrometric method developed and results were compared statistically. Results:We found that native and total thiol levels were significantly decreased in patients with lung tuberculosis, disulphide/native thiol and disulphide/total thiol levels were found to be higher in lung tuberculosis patients when compared with the control group. However, disulphide levels were higher in the control group than in the patient group. Conclusions:Based on the results of this study, it can be said that oxidative stress is closely associated with lung tuberculosis pathogenesis. There is a need for new studies that will show the possible effects of oxidative stress on lung tuberculosis pathogenesis.

Aim: Our aim in this study is to determine the C-reactive protein/ Albumin ratio (CAR) values of computed tomography (CT) -positive COVID-19 patients and CT-negative COVID-19 patients and to investigate the relationship between C-reactive protein/Albumin ratio and radiological images of patients. Material and Method:A-hundred COVID-19 patients over the age of 18 were included in our study. C-reactive protein (CRP), albumin levels and lung CT scan were collected. We divided the patients into two sections: CT-positive and CT-negative. We investigated the relationship between CT and CAR in patients, with and without comorbidity. Results:The measured CRP levels and CAR in the CT-positive group were significantly higher than CT-negative group (37.76±64, 9.05±22, p=0.001, 11.8±23.2, 2.12±5.42, p=0.0 01). The measured albumin levels of CT-positive group were significantly lower than the CT-negative group (4.12±0.63, 4.53±0.36, p=0.001). When we evaluate the patients by excluding those with comorbidity; CRP levels and CAR measured in the CT-positive group were significantly higher than in the CT-negative group. (15.94±19.2, 6.07±7.38, p=0.013, 4.57±6.82, 1.38±1.75, p=0.016). Although the albumin values of CT-positive patients were lower than those of CTnegative patients, no statistically significance was found. Conclusion:In general, we found that CAR levels in CT-positive patients were significantly higher than in CT-negative patients. In cases where CT is contraindicated (such as pregnancy), CAR can be used to indicate lung involvement or to follow-up patients with pulmonary involvement.

Introduction: Ongoing research aims to investigate blood-based biomarkers and use them in acute ischaemic stroke (AIS) diagnosis and management of patients with AIS.Purpose: The purpose of the present study was to investigate the meteorin-like protein (Metrnl) levels secreted by adipose tissue in patients with AIS.Methods: The study groups included healthy controls (n=30) and patients diagnosed with AIS via magnetic resonance imaging (MRI) in the emergency department (n=35) during the one-year period. The basic laboratory values and Metrnl, total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) levels of the patients were compared. The Metrnl levels were measured using enzymelinked immunosorbent assays.Results: In the present study, the Metrnl (p=0.001) and TAC (p=0.009) levels decreased significantly, whereas the TOS (p<0.001) and OSI (p<0.001) levels increased significantly in the patients with AIS compared to the healthy controls. Furthermore, a cut-off value of ≤1.63% meteorin-like protein rendered the sensitivity and specificity rates of 91.43% and 71.43%, respectively, in the patients with AIS. In addition, there was a significant negative correlation between the decreased meteorin-like protein levels and the infarct diameter in patients with AIS. Conclusion:In patients with AIS, the meteorin-like protein levels decreased inversely with the infarct diameter, and at the same time, there was an increase in TOS and OSI levels and a decrease in TAC levels.