Evaluation of dynamic thiol-disulphide homeostasis in obstructive uropathy

Tokuç, Emre; Ürkmez, Ahmet; Can, Unal; Orak, Rahime; Gumrukcu, Gulistan; Erel, Özcan; Kutluhan, Musab Ali; Sertkaya, Zülfü; Öztürk, Metin İshak

doi:10.1007/s11255-020-02377-2

Cited by 3 publications

(2 citation statements)

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“…More studies are needed for evaluating its role in early or advanced ccRCC. TDH status was used to evaluate the severity of multiple renal and inflammatory diseases (urolithiasis, obstructive uropathy, urinary tract infections, autosomal dominant polycystic disease, acute renal failure, chronic kidney disease, hemodialysis, peritoneal dialysis, renal transplantation) [29][30][31][32]34,35,[63][64][65].…”

Section: Discussionmentioning

confidence: 99%

“…The balance between the serum levels of thiol-proteins (albumin, cysteine, cysteinyl-glycine, glutathione, homocysteine, γ-glutamyl-cysteine-albumin) and the disulfides plays a protective role in cellular redox homeostasis [26,29]. In the literature, abnormal thiol/disulfide homeostasis was not evaluated in cancer patients, but it was associated with urolithiasis, hemodialysis, peritoneal dialysis, renal transplantation patients, acute renal failure, chronic kidney disease, obstructive uropathy, autosomal dominant polycystic kidney disease, urinary tract infections, and malignancy [28][29][30][31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

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Posttranslational Modifications Pattern in Clear Cell Renal Cell Carcinoma

et al. 2020

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Posttranslational modifications are dynamic enzymatic-mediated processes, regulated in time and space, associated with cancer development. We aimed to evaluate the significance of posttranslational modifications in the pathogenesis of clear cell renal cell carcinoma. The authors developed a prospective, observational study during a period of three years and included 55 patients with localized renal cell carcinoma and 30 heathy subjects. Glycosylation, nitration and carbonylation, thiol-disulfide homeostasis, methylation, phosphorylation and proteolytic cleavage were evaluated in the serum of the evaluated subjects in the present study. Our results showed some characteristics for early ccRCC: high production of cytokines, substrate hypersialylation, induced nitrosative and carbonylic stress, arginine hypermethylation, thiol/disulfide homeostasis (TDH) alteration, the regulatory role of soluble receptors (sRAGE—soluble receptor for advanced glycation end products, sIL-6R—soluble receptor for Interleukin 6) in RAGE and IL-6 signaling, the modulatory effect of TK1—thymidine kinase 1 and TuM2-PK—tumoral pyruvate-kinase 2 in controlling the level of phosphometabolites in neoplastic cells. These data could be the initial point for development of a panel of biomarkers such as total sialic acid, orosomucoids, nitrotyrosine, carbonylic metabolites, Asymmetric Dimethylarginines (ADMA), Symmetric Dimethylarginines (SDMA), and thiol-disulfide equilibrium for early diagnosis of ccRCC. Moreover, they could be considered a specific disease posttranslational modification signature which underlines the transition from early to advanced stages in this neoplasia, and of a therapeutic target in kidney oncogenesis.

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