Evaluation of Effect of Nishamalaki on  STZ and HFHF Diet Induced Diabetic  Neuropathy in Wistar Rats

Dawane, Jayshree; Pandit, Vijaya; Bhosale, Madhura Shirish Kumar; Khatavkar, Pallawi Shashank

doi:10.7860/jcdr/2016/21011.8752

Cited by 9 publications

(7 citation statements)

References 19 publications

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“…Peripheral vascular disease (PVD) and diabetic neuropathy are the 2 main risk factors for DFU [10]. Diabetic neuropathy can affect almost 50% of patients with DM [11]. Symptoms can affect sensory, motor, or autonomic functions [11].…”

Section: Discussionmentioning

confidence: 99%

Low-Level Laser Therapy (LLLT) for Diabetic Foot Ulcer in Uncontrolled Diabetes: A Case Report of Improved Wound Healing

Waluyo,

Hidayat

2024

Am J Case Rep

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Unusual clinical course Background:Diabetes mellitus (DM) is one of the most prevalent diseases worldwide and is associated with increased morbidity and mortality. One of the microvascular complications of DM is diabetic foot ulcer (DFU), which is associated with increased mortality from serious infections and decreased functional capacity of the patient due to amputation. Uncontrolled diabetes is a significant risk factor for poor wound healing. There is a need for alternative treatments that can promote wound healing in these patients. Several studies have shown the effect of low-level laser therapy (LLLT) on wound healing in patients with DFU. LLLT is a potential therapeutic approach in patients with DFU. Case Report:A 55-year-old male patient presented with a history of DM, diabetic neuropathy, and diabetic foot. The patient had uncontrolled blood sugar levels, with an HbA1C of 9.3%. The patient received therapy in the form of wound care with normal saline, topical antibiotics, and LLLT, with a dose of 10 J/cm 2 with a frequency of therapy 3 times per week. After 12 weeks of therapy, there was improvement, characterized by wound tissue growth and no significant adverse effects during therapy. Conclusions:LLLT can provide benefits in patients with DFU and uncontrolled diabetes. The wound showed improvement after 12 weeks of therapy, and there were no significant adverse effects during therapy. LLLT is a minimally invasive, easy-to-use, and inexpensive therapeutic option to induce wound healing in patients with DFU and uncontrolled diabetes.

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Section: Discussionmentioning

confidence: 99%

Low-Level Laser Therapy (LLLT) for Diabetic Foot Ulcer in Uncontrolled Diabetes: A Case Report of Improved Wound Healing

Waluyo,

Hidayat

2024

Am J Case Rep

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“…Apart from other actions, antioxidant action appears to be the most important mechanism. [ 11 ] Khadiradi vati is a medicine which acts as lozenge to relieve local throat and nasal irritations. Also, it maintains oral hygiene which is most recommended for a patient with fever and diabetes in Ayurveda.…”

Section: Discussionmentioning

confidence: 99%

Multimodal ayurvedic approach in the management of moderate SARS-COV2 infection with co-morbidities – A case report

Mythri

Mahto

2022

Journal of Family Medicine and Primary Care

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Introduction: The World Health Organization (WHO) declared COVID-19 a pandemic which has claimed more than 1.4 million lives as of today. This unprecedented period demands greatly for the traditional and native medical systems which are time-tested and holistic. Some of the recent studies have reported severe infection in individuals with comorbidities such as obesity, diabetes mellitus, old age, etc. Ayurveda understands this condition as Agantuja Jwara of Sannipatika origin. Madhumeha (diabetes mellitus) is basically a disease of depleted Ojus (immunity) as per Ayurveda. Methods: Here, we report a case of COVID-19 in an elderly overweight patient with diabetes, which was managed successfully with Ayurvedic medicines, diet, lifestyle, yoga, and rejuvenative therapy. Case Description: A 70-year-old male consulted our physician through phone call and willfully wanted to take Ayurvedic management for COVID-19. On the 1 st day of treatment, the patient complained of fever at 103 F, headache, and severe body ache. Later on, started with a cough, headache, shortness of breath, excessive thirst, etc. Based on the symptom cluster and food-exercise routine, Kapha and Pitta were the vitiated body humors. Results: After thorough Ayurvedic assessment, the patient was administered with Langhana, Pachana (procedures to improve digestive metabolism), anti-pyretic, and antidiabetic medications followed by yoga and pranayama. The patient was also advised rejuvenative therapy to prevent further post-COVID complications. Quality of Life was assessed with Quality of Life Instrument for Indian Diabetes Patients (QOLID) and EuroQol five-dimensional (EQ-5D). The patient was completely relieved from major symptoms in 4 days and tested negative after 12 days, with considerable improvement in QOL. The case was followed up for 60 days, and no post-COVID symptoms were reported.

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“…The classical literature of Ayurveda credited anti-diabetic values to these drugs and recent researches substantiated the role of herbal drugs in the management of different phases of diabetes. [ 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 ] A few mineral/metal-based formulations including Shilajatu ( Asphaltum punjabianum ), Chandraprabha Vati , Shilajatvadi Lauha and some patented formulations were also being used by the diabetes patients. [ 38 39 40 41 ] The underlying anti-diabetic effects of these herbs may be because of one or the other types of the mechanism involving a direct effect on insulin secretion, activation of glycogenesis and hepatic glycolysis, adreno-mimeticism, pancreatic beta-cell potassium channel blocker activity, cAMP activation, and/or modulation of glucose absorption from the intestine, etc.…”

Section: Discussionmentioning

confidence: 99%

Patterns of concomitant use of Ayurveda and conventional anti-diabetic formulations - Experiences at a tertiary care Ayurveda hospital, India

Galib

Dang

Kumar

et al. 2020

AYU

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Background: Majority of the population relies on traditional medicines for many of their health related problems. Particularly individuals with chronic illness like diabetes mellitus (DM) are more likely to simultaneously use herbal medicines. Many of such users believe that traditional medicines are natural and therefore safe, but this is a dangerous over simplification. Some herbal medicines may be associated with adverse effects, which include interactions with prescribed drugs. Information on such concomitant use of anti-diabetic drugs along with Ayurveda medicines is limited in Indian scenario. Aims and objectives: To survey the patterns of concomitant use of Ayurveda and conventional anti-diabetic drugs by diabetic patients attending an out-patient department of a tertiary care teaching hospital in New Delhi, India through a validated questionnaire. Materials and methods: This is a questionnaire-based survey, carried out after the approval of the Institutional Ethics Committee, subsequently registered at CTRI. A questionnaire to assess the pattern of concomitant use was developed; content was validated and pre-tested by a pilot study in 40 patients, further refined and used in the survey. The data was analyzed to evaluate the patterns of concomitant use of Ayurvedic and conventional anti-diabetic drugs. Results: About 95.9% of diabetic patients were taking herbo-mineral formulations concomitantly with conventional anti-diabetic drugs. Although 45.3% of diabetics were using Ayurveda interventions under the supervision of qualified AYUSH physicians, remaining involved in procuring the drugs over the counter (OTC) or from the local vendors. In majority of these instances, the use of Ayurveda formulations was not communicated with their physicians. Conclusion: The observations reveal that a majority of the diabetics (95.9%) were taking one or the other form of herbal preparations along with their conventional anti-diabetic drugs and about 44% among them were using these concomitantly. Thus, generating awareness on good practices of drug use seems to be essential.

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Evaluation of Effect of Nishamalaki on STZ and HFHF Diet Induced Diabetic Neuropathy in Wistar Rats

Cited by 9 publications

References 19 publications

Low-Level Laser Therapy (LLLT) for Diabetic Foot Ulcer in Uncontrolled Diabetes: A Case Report of Improved Wound Healing

Low-Level Laser Therapy (LLLT) for Diabetic Foot Ulcer in Uncontrolled Diabetes: A Case Report of Improved Wound Healing

Multimodal ayurvedic approach in the management of moderate SARS-COV2 infection with co-morbidities – A case report

Patterns of concomitant use of Ayurveda and conventional anti-diabetic formulations - Experiences at a tertiary care Ayurveda hospital, India

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