Evaluation of effective connectivity of motor areas during motor imagery and execution using conditional Granger causality

Gao, Qing; Duan, Xujun; Chen, Huafu

doi:10.1016/j.neuroimage.2010.08.071

Cited by 156 publications

(144 citation statements)

References 84 publications

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“…Thereby, these two areas have been consistently found to be significantly activated during both motor execution and motor imagery tasks (Gao et al, 2011;Gerardin et al, 2000;Guillot et al, 2008;Hanakawa et al, 2003;Jeannerod, 1994;Michelon et al, 2006;Solodkin et al, 2004;Szameitat et al, 2007). These functional results were largely in agreement with the anatomical findings in monkeys and humans, showing that the SMA was densely and reciprocally connected with the hand area of M1 (Arai et al, 2012;Johansen-Berg et al, 2004;Luppino et al, 1993;Muakkassa and Strick, 1979;Rouiller et al, 1994).…”

supporting

confidence: 84%

“…The influence of SMA on M1 has been consistently confirmed by many effective connectivity measurements such as Granger causality analysis (Chen et al, 2009;Gao et al, 2008Gao et al, , 2011Sato et al, 2006), structural equation modeling (Solodkin et al, 2004), and dynamic causal modeling (DCM) (Grefkes et al, 2008). These results demonstrated a predominantly facilitatory function of the SMA in the top-down processes during motor execution (Arai et al, 2012;Gao et al, 2011;Grefkes et al, 2008), and implied that ipsilateral and contralateral SMAs played different roles on contralateral M1 (Gao et al, 2011).…”

mentioning

confidence: 70%

“…As for motor imagery where there is no overt body movement, the connectivity network analyses have shown a similar SMA-M1 connectivity pattern (Gao et al, 2011;Solodkin et al, 2004). Importantly, using DCM, Kasess et al (2008) showed that the SMA exerts suppressive influence over contralateral M1 during motor imagery, whereas Grefkes et al (2008) demonstrated the facilitation of SMA on contralateral M1 during motor execution.…”

mentioning

confidence: 82%

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Differential Contribution of Bilateral Supplementary Motor Area to the Effective Connectivity Networks Induced by Task Conditions Using Dynamic Causal Modeling

et al. 2014

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Functional imaging studies have indicated hemispheric asymmetry of activation in bilateral supplementary motor area (SMA) during unimanual motor tasks. However, the hemispherically special roles of bilateral SMAs on primary motor cortex (M1) in the effective connectivity networks (ECN) during lateralized tasks remain unclear. Aiming to study the differential contribution of bilateral SMAs during the motor execution and motor imagery tasks, and the hemispherically asymmetric patterns of ECN among regions involved, the present study used dynamic causal modeling to analyze the functional magnetic resonance imaging data of the unimanual motor execution/imagery tasks in 12 right-handed subjects. Our results demonstrated that distributions of network parameters underlying motor execution and motor imagery were significantly different. The variation was mainly induced by task condition modulations of intrinsic coupling. Particularly, regardless of the performing hand, the task input modulations of intrinsic coupling from the contralateral SMA to contralateral M1 were positive during motor execution, while varied to be negative during motor imagery. The results suggested that the inhibitive modulation suppressed the overt movement during motor imagery. In addition, the left SMA also helped accomplishing left hand tasks through task input modulation of left SMA/right SMA connection, implying that hemispheric recruitment occurred when performing nondominant hand tasks. The results specified differential and altered contributions of bilateral SMAs to the ECN during unimanual motor execution and motor imagery, and highlighted the contributions induced by the task input of motor execution/imagery.

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confidence: 84%

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confidence: 70%

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confidence: 82%

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Differential Contribution of Bilateral Supplementary Motor Area to the Effective Connectivity Networks Induced by Task Conditions Using Dynamic Causal Modeling

et al. 2014

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“…Several studies have investigated the brain substrates of motor imagery, i.e. mental rehearsal in one's mind's eye of a movement, and have found that motor imagery activates to a large extent the same brain networks involved in motor execution, including parts of the SMA, the dorsal premotor cortex, the posterior parietal cortex, the cerebellum and M1 in certain conditions (Lui et al, 2008;Gao et al, 2011;Raffin et al, 2012), showing the potential role of motor imagery in motor rehabilitation (Sharma et al, 2006). Recent functional neuroimaging studies, using region of interest analyses, however, have shown a specific pattern associated with motor execution and imagery (Raffin et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Brain Activation Patterns Characterizing Different Phases of Motor Action: Execution, Choice and Ideation

et al. 2016

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Motor behaviour is controlled by a large set of interacting neural structures, subserving the different components involved in hierarchical motor processes. Few studies have investigated the neural substrate of higher-order motor ideation, i.e. the mental operation of conceiving a movement. The aim of this functional Magnetic Resonance Imaging (fMRI) study was to segregate the neural structures involved in motor ideation from those involved in movement choice and execution. An index finger movement paradigm was adopted, including three different conditions: performing a pre-specified movement, choosing and executing a movement and ideating a movement of choice.The tasks involved either the right or left hand, in separate runs. Neuroimaging results were obtained by comparing the different experimental conditions and computing conjunction maps of the right and left hands for each contrast. Pre-specified movement execution was supported by bilateral fronto-parietal motor regions, the cerebellum and putamen. Choosing and executing finger movement involved mainly left fronto-temporal areas and the anterior cingulate. Motor ideation activated almost exclusively left hemisphere regions, including the inferior, middle and superior frontal regions, middle temporal and middle occipital gyri. These findings show that motor ideation is controlled by a cortical network mainly involved in abstract thinking, cognitive and motor control, semantic and visual imagery processes.

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“…Predominantly left lateralised, the ventro-dorsal stream extends from occipital cortex to the left IPL, to the ventral premotor cortex and frontal eye fields (Frey 2007;Rizzolatti, Fogassi, & Luppino, 2011). The ventro-dorsal stream is purportedly critical in skilled action execution, movement perception, and mental representations of movement (or motor imagery) that may be necessary when retrieving postural requirements related to skilled object-use and object manipulation (Jeannerod, 1994;Buccino et al, 2001;Kosslyn, Ganis, & Thompson, 2001;Solodkin, Hlustik, Chen, & Small, 2004;Johnson-Frey, Newman-Norland, & Grafton, 2005;Buxbaum, Kyle, Tang, & Detre, 2006;Lotze & Cohen, 2006;Creem-Regehr, 2009;Rizzolatti & Craighero, 2004;Buxbaum & Kalénine, 2010;Gao, Duan, & Chen, 2011). It is therefore possible that skilled action execution, motor imagery and movement perception may involve a common process that critically relies on the ventrodorsal stream.…”

Section: Introductionmentioning

confidence: 99%

Perceptual decisions regarding object manipulation are selectively impaired in apraxia or when tDCS is applied over the left IPL

et al. 2016

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This study evaluated whether apraxia can be understood as due to impaired motor representations or motor imagery necessary for appropriate object-use, imitation, and pantomime. The causal role of the left inferior parietal lobe (IPL), which is heavily implicated in apraxia, is also evaluated. These processes are appraised in light of the proposed ventro-dorsal sub-stream of the classic two visual pathway model, where perceptual information from the ventral stream and the dorsal action stream are integrated and essential for object manipulation. Using a task assessing object-use perception, stroke patients with apraxia demonstrated a selective deficit during perceptual decisions reliant on the integration of visible and known object properties to select the appropriate grasp for object-use. This deficit increased with apraxia severity. A dissociation was evident in these patients showing intact non-motoric perceptual decisions regarding the functional semantic relationship between two objects in the absence of the actor (e.g. how a hammer hits a nail). Converging evidence was found using a modified version of the same task in a neuromodulation study that directly targeted the left IPL in healthy participants using transcranial direct current stimulation (tDCS). Application of inhibitory stimulation over the left IPL reduced performance during perceptual decisions regarding object manipulation whilst performance was unaffected during functional semantic decisions. Excitatory stimulation of the left IPL did not affect performance in either task. Combined, these results suggest that the left inferior parietal lobe is critical for motor imagery, and that apraxia may be caused by an inability to use internal motor representations of object manipulation. These results are discussed in terms of motoric and non-motoric perceptual processes and the proposal of an additional ventro-dorsal sub-stream within the dorsal and ventral visual pathways model

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Evaluation of effective connectivity of motor areas during motor imagery and execution using conditional Granger causality

Cited by 156 publications

References 84 publications

Differential Contribution of Bilateral Supplementary Motor Area to the Effective Connectivity Networks Induced by Task Conditions Using Dynamic Causal Modeling

Differential Contribution of Bilateral Supplementary Motor Area to the Effective Connectivity Networks Induced by Task Conditions Using Dynamic Causal Modeling

Brain Activation Patterns Characterizing Different Phases of Motor Action: Execution, Choice and Ideation

Perceptual decisions regarding object manipulation are selectively impaired in apraxia or when tDCS is applied over the left IPL

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