Evaluation of effects of platelet-rich plasma on human facial skin

Yüksel, Esra Pancar; Şahin, Gökhan; Aydın, Fatma; Şentürk, Nilgün; Turanlı, Ahmet Yaşar

doi:10.3109/14764172.2014.949274

Cited by 81 publications

(66 citation statements)

References 19 publications

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“…They reported that PRP combined with fractional laser increased subject satisfaction and skin elasticity, the amount of collagen, and the number of fibroblasts. Yuksel et al11 investigated the effect of PRP on the human facial skin. They applied to PRP with dermaroller and intradermal injections.…”

Section: Discussionmentioning

confidence: 99%

Histologic Evidence of New Collagen Formulation Using Platelet Rich Plasma in Skin Rejuvenation: A Prospective Controlled Clinical Study

et al. 2016

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BackgroundPlatelet-rich plasma (PRP) is an autologous concentration of human platelets contained in a small volume of plasma and has recently been shown to accelerate rejuvenate aging skin by various growth factors and cell adhesion molecules.ObjectiveThis study was conducted to evaluate the efficacy and safety of intradermal injection of PRP in the human facial rejuvenation.MethodsThis study was a prospective, single-center, single-dose, open-label, non-randomized controlled clinical study. PRP injected to the upper site of this right infra-auricular area and all face. Saline was injected to the left infra-auricular area. Histopathological examinations were performed before PRP treatment, 28 days after the PRP, and saline (control) treatments.ResultsTwenty women ranging in age from 40 to 49 years (mean age, 43.65±2.43 years) were enrolled in the study. The mean optical densities (MODs) of collagen in the pre-treatment, control, and PRP-treated area were measured. They were 539±93.2, 787±134.15, 1,019±178, respectively. In the MOD of PRP, 89.05 percent improvement was found when MOD of PRP was compared with MOD of pre-treatment. The mean MOD of collagen fibers was clearly highest on the PRP side (p<0.001). The PRP-to-saline improvement ratio (89.05% to 46.01%) was 1.93:1. No serious side effects were detected.ConclusionPRP increases dermal collagen levels not only by growth factors, but also by skin needling (the mesotherapy technique 'point by point'). PRP application could be considered as an effective (even a single application) and safety procedure for facial skin rejuvenation.

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Section: Discussionmentioning

confidence: 99%

Histologic Evidence of New Collagen Formulation Using Platelet Rich Plasma in Skin Rejuvenation: A Prospective Controlled Clinical Study

et al. 2016

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“…P-PRP was applied to the forehead, malar area, and jaw by a dermaroller, as well as injected using a 27-gage needle into the wrinkles of crow's feet. They found there was a statistically significant difference between the general appearance, skin firmness-sagging and wrinkle state before and after the applications [46]. Mehryan et al assessed the effect of P-PRP on infraorbital dark circles and crow's feet.…”

Section: Human Trialsmentioning

confidence: 97%

Platelet Preparations for Use in Facial Rejuvenation and Wound Healing: A Critical Review of Current Literature

Sclafani

Azzi

2015

Aesth Plast Surg

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In facial plastic surgery, the potential for direct delivery of growth factors from platelet preparations has been of particular interest for use in facial rejuvenation, recovery after facial surgery, and wound healing. A literature search was conducted through PubMed for the terms PRP, PRFM, platelet-rich plasma, platelet-rich fibrin matrix, platelet preparations, platelet therapy, growth factors, platelet facial, platelet facial rejuvenation, platelet wound healing, platelet plastic surgery. Articles pertaining to the use of platelet preparations in facial surgery and wound healing in plastic surgery after 2001 were included. Thirteen in vitro studies showed use of platelet-rich plasma (PRP) and platelet-rich fibrin matrix (PRFM) had a significant effect on cellular activity. Twenty-four out of 28 animal studies exhibited favorable results with use of a platelet preparation, including five of six studies that showed enhanced fat graft survival with addition of a platelet preparation. Twenty-three case series and clinical trials were identified, only two of which showed no differences. Twenty-one reported favorable results with use of various platelet preparations. A total of 47 studies used PRP, four studies evaluated Leukocyte-rich PRP, and fourteen studies used PRFM. The vast majority of studies examined show a significant and measurable effect on cellular changes, wound healing, and facial esthetic outcomes with use of platelet preparations, both topical and injectable. One must also consider possible publication bias against null results that may have had an influence on the data that were available for review. However, the preponderance of studies suggests that platelet preparations might represent an as-of-yet untapped adjunct in facial plastic surgery.

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“…Pancar ve ark. 'nın (11) yaptığı çalışmada, 10 sağlıklı gönüllü-ye 2 hafta ara ile 3 kez yüz derisine PRP uygulaması yapılmış ve genel görünüm, cilt sıkılığı ve kırışıklık durumu yönünden PRP grubunda anlamlı farklılık gözlenmiştir. Margolis ve ark.…”

Section: Platelet-zengin Plazma Ile Yapılan Insan Ve Deneysel Havyan unclassified

Current developments in platelet-rich plasma therapy

Koca¹

2015

Okmeydani Medical Journal

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Evaluation of effects of platelet-rich plasma on human facial skin

Abstract: PRP application could be considered as an effective procedure for facial skin rejuvenation.

Cited by 81 publications

References 19 publications

Histologic Evidence of New Collagen Formulation Using Platelet Rich Plasma in Skin Rejuvenation: A Prospective Controlled Clinical Study

Histologic Evidence of New Collagen Formulation Using Platelet Rich Plasma in Skin Rejuvenation: A Prospective Controlled Clinical Study

Platelet Preparations for Use in Facial Rejuvenation and Wound Healing: A Critical Review of Current Literature

Current developments in platelet-rich plasma therapy

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