Evaluation of efficacy and safety of orlistat in obese patients

Jain, Suyog; Ramanand, Sunita J.; Ramanand, Jaiprakash; Akat, Pramod B; Patwardhan, Milind; Joshi, Sachin R

doi:10.4103/2230-8210.81938

Cited by 51 publications

(40 citation statements)

References 14 publications

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“…Orlistat therapy in the current study produced a significant reduction in BMI, TC, WC without significant effects on VAI compared to baseline values. These findings corresponded with other studies which demonstrated that orlistat therapy produced a significant body weight reductions in obese patients with additional amelioration on lipid profile, anthropometric measures, inflammatory markers (tumor necrosis factor a [TNF-a] and interleukin 6 [IL-6]), and cardiometabolic risk factors [ 17 , 18 ].…”

Section: Discussionsupporting

confidence: 90%

Effect of orlistat alone or in combination with Garcinia cambogia on visceral adiposity index in obese patients

Al-Kuraishy¹,

Al-Gareeb²

2016

J Intercult Ethnopharmacol

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Aim:The objective of this study was to estimate the effect of orlistat alone and in combination with Garcinia cambogia on visceral adiposity index (VAI) in obese patients.Patients and Methods:A total of 99 obese male patients were recruited with aged range between 37 and 46 years. They were randomized into three equal groups, first group treated with orlistat 120 mg/day, second group treated with G. cambogia 166 mg/day, and third group treated with orlistat 120 mg/day plus G. cambogia 166 mg/day. The duration of the treatments was three consecutive months. Body mass index (BMI), VAI, blood pressure, blood glucose, total lipid profile, atherogenic index, and cardiac risk ratio were recorded at baseline and after 3 months.Results:The treatment with G. cambogia leads to reduction in VAI P < 0.05, whereas orlistat has a beneficial effect on cardiometabolic profiles without a reduction in VAI P > 0.05. Combined therapy of G. cambogia plus orlistat showed the more significant effect in reduction of VAI P < 0.05, cardiometabolic profiles and anthropometric measures P < 0.01 compared to pretreatment period.Conclusion:Combination of G. cambogia with orlistat lead to more significant effect than orlistat alone in amelioration of cardiometabolic profile and VAI in obese patients.

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Section: Discussionsupporting

confidence: 90%

Effect of orlistat alone or in combination with Garcinia cambogia on visceral adiposity index in obese patients

Al-Kuraishy¹,

Al-Gareeb²

2016

J Intercult Ethnopharmacol

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“…This finding suggests that betulinic acid may inhibit the uptake of dietary fat. Although the inhibitory activity of orlistat was stronger than that of betulinic acid, orlistat causes serious gastrointestinal side effects such as oily stools, abdominal pain and fecal urgency (Jain et al ., ). Botanicals may provide safe, natural and cost‐effective alternatives to synthetic drugs (Zdunczyk et al ., ).…”

Section: Resultsmentioning

confidence: 97%

Betulinic Acid has an Inhibitory Effect on Pancreatic Lipase and Induces Adipocyte Lipolysis

Kim

Lee

Kim

et al. 2011

Phytotherapy Research

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Betulinic acid is a pentacyclic triterpenic acid that exists naturally in many kinds of food and has many biological functions. The present study investigated the antiobesity properties of betulinic acid and possible mechanisms by which betulinic acid functions. To examine the antilipase function of betulinic acid, the ability of betulinic acid to inhibit pancreatic lipase activity in vitro and to prevent the elevation of plasma triacylglycerol levels was tested after oral administration of a lipid emulsion in rats. In addition, the lipolytic effects of betulinic acid were assayed in rat adipose tissues. The activity of cAMP-dependent phosphodiesterase was also measured in vitro. Betulinic acid inhibited pancreatic lipase activity in a dose-dependent manner at concentrations of 1.5-100 µM (IC₅₀ value of 21.10 µM) and prevented the elevation of plasma triacylglycerol levels 2 h after oral administration of the lipid emulsion at a dose of 100 mg/kg. In addition, betulinic acid had a strong lipolytic effect, which was mediated by cAMP-dependent phosphodiesterase inhibition. In conclusion, betulinic acid may exert antiobesity effects by directly inhibiting pancreatic lipase, which would prevent the absorption of lipid from the small intestine. In addition, it was found that betulinic acid may further accelerate fat mobilization by enhancing the levels of lipolysis in adipose tissues.

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“…A range of strategies can be employed for weight loss which includes lifestyle changes (diet, exercise), behavioral therapy, pharmacotherapy, and surgery. Orlistat is an effective and well-tolerated antiobesity drug, which can be employed as an adjunct to therapeutic lifestyle changes to achieve and maintain optimal weight [ 25 ]. But most antiobesity drugs act on the central nervous system to suppress appetite, reduce food intake, and have serious adverse effects.…”

Section: Discussionmentioning

confidence: 99%

The Evaluation of the Body Weight Lowering Effects of Herbal Extract THI on Exercising Healthy Overweight Humans: A Randomized Double-Blind, Placebo-Controlled Trial

Cho

Yoon

Yang

2013

Evidence-Based Complementary and Alternative Medicine

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We investigated the effects of herbal extracts, a mixture of Scutellariae Radix and Platycodi Radix containing the active ingredients Baicalin and Saponin (target herbal ingredient (THI)), on lowering body weight. The present study was a prospective, randomized, double-blind, and placebo-controlled trial carried out at the outpatient department of a hospital over a period of 2 months. Group 1 patients (n = 30) received THI, and group 2 patients (n = 23) received placebo three times a day before meals. Weight, waist circumference, BMI, total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, and glucose were measured at baseline and again at the 2nd month. For safety evaluation, various hematological and biochemical parameters were assessed. Values of mean change of weight in the THI-treated group were −1.16 ± 1.41 kg and in the placebo-treated group were −0.24 ± 1.70 kg, respectively. The difference in mean change of weight in the THI-treated group compared with that in the placebo-treated group was statistically significant (P < 0.05). The incidence of subjective and objective adverse drug reactions was insignificant (P > 0.05). THI was statistically significant in its effectiveness on the weight loss.

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Evaluation of efficacy and safety of orlistat in obese patients

Cited by 51 publications

References 14 publications

Effect of orlistat alone or in combination with Garcinia cambogia on visceral adiposity index in obese patients

Effect of orlistat alone or in combination with Garcinia cambogia on visceral adiposity index in obese patients

Betulinic Acid has an Inhibitory Effect on Pancreatic Lipase and Induces Adipocyte Lipolysis

The Evaluation of the Body Weight Lowering Effects of Herbal Extract THI on Exercising Healthy Overweight Humans: A Randomized Double-Blind, Placebo-Controlled Trial

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