Evaluation of Efficiency of Two Nanohydroxyapatite Remineralizing Agents with a Hydroxyapatite and a Conventional Dentifrice: A Comparative In vitro Study

Singh, Abhishek; Shetty, Balamohan; Mahesh, C M; Reddy, Vinay P; Chandrashekar, BS; Mahendra, S

doi:10.1177/0974909820170206

Cited by 4 publications

(2 citation statements)

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“…Hydroxyapatite has been used as a remineralising agent in toothpaste for the past three decades, and in Japan since 1993, studies have shown a reduction in the caryogenic index among students who used this toothpaste. It is a crystalline calcium phosphate substance almost identical to natural hydroxyapatite, supplied as nanoparticles, which directly replaces minerals lost from demineralised enamel and completes microscopic cracks on the surface of the enamel [20][21][22][23][24]. In recent years, more oral hygiene products with hydroxyapatite have appeared on the market due to its benefits in remineralising enamel, increasing resistance to bacterial plaque adhesion and reducing dentinal hypersensitivity.…”

Section: Experimental Partmentioning

confidence: 99%

The Effect of Hydroxyapatite from Various Toothpastes on Tooth Enamel

Jumanca¹,

Matichescu²,

Găluşcan³

et al. 2019

Rev. Chim.

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The process of re-demineralisation is governed by the degree of mineral saturation of oral fluids. Due to positive changes in conditions, remineralisation can become the predominant process leading to the healing of injuries. To improve remineralisation, it is necessary to increase the concentration of calcium and fluoride in oral fluids. For this purpose, fluorides have traditionally been used in varied forms and concurrently, the cariostatic mechanism can be explained by increasing the force of fluorapatites. The aim of this paper was to demonstrate the importance of using toothpastes containing hydroxyapatite on tooth enamel and how to operate at microscopic level by sealing the enamel and enamel prism defects etched by acid. The specimens obtained from extracted teeth were treated with different types of toothpastes containing hydroxyapatite: Biorepair, Sensodyne Repair & Protect and Lacalut White & Repair. We treated the teeth with the aforementioned toothpastes, followed the study under SEM microscope. We compared the control sample with the treated sample, and then the treated samples were compared to each other. All three toothpastes used had the expected result, making a protective layer on the surface of the etched enamel, but in this study, the Sensodyne toothpaste seems to be the most effective.

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Section: Experimental Partmentioning

confidence: 99%

The Effect of Hydroxyapatite from Various Toothpastes on Tooth Enamel

Jumanca¹,

Matichescu²,

Găluşcan³

et al. 2019

Rev. Chim.

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“…Studies have shown that nano-HAP applied as a toothpaste or in topical cream form has the ability to remineralize initial caries lesions. [24][25][26][27][28][29][30][31][32][33][34][35] It is thought that nano-HAP may serve as a calcium and phosphate reservoir, maintaining a state of supersaturation of these ions at the tooth surface and thereby promoting crystal deposition and growth. 36 Initial in vitro studies established the potential of nano-HAP to occlude dentin tubules as a surrogate measure of its ability to relieve DHS symptoms.…”

Section: Introductionmentioning

confidence: 99%

Clinical efficacy of nanohydroxyapatite-containing toothpaste at relieving dentin hypersensitivity: an 8 weeks randomized control trial

Lemke¹,

Saha²,

Luong³

et al. 2021

BDJ Open

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Objective The objective of this study was to investigate and compare the effectiveness of several toothpastes containing nanohydroxyapatite (nano-HAP) to relieve dentin hypersensitivity (DHS) with that of a commercial desensitizing dentifrice containing calcium sodium phosphosilicate (CSPS). Materials and methods In this double-blind, randomized, parallel-group clinical trial, patients diagnosed with DHS and qualified to participate were randomized into four groups: toothpaste containing 10% nano-HAP (10%nano-HAP), 15% nano-HAP (15%nano-HAP), 10% nano-HAP supplemented with potassium nitrate (KNO3) (10%nano-HAPKN), or CSPS. Subjects’ baseline and post-treatment sensitivities were assessed using visual analog scale (VAS) after the application of ice-cold and air stimuli. Subjects used their assigned toothpaste for routine toothbrushing twice daily. Post-treatment sensitivity was assessed every 2 or 8 weeks. Mean change in VAS (mm) from baseline at each time point were compared using random-intercept, mixed-model analysis and Duncan test (P < 0.05). Results With either air or cold stimulus, VAS indicated a significant (P < 0.001) reduction from baseline DHS at each time point with all test toothpastes. Among the nano-HAP toothpastes, 15%nano-HAP and 10%nano-HAPKN were consistent in DHS reduction with both stimuli. With either stimuli, the CSPS did not significantly differ from 15%nano-HAP and 10%nano-HAPKN at any time point. Conclusions Toothpaste containing nano-HAP (10 or 15%) alone or supplemented with KNO3 was as effective as CSPS for relief of DHS symptoms when used at least twice daily.

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