Evaluation of Elution and Mechanical Properties of Two Injectable Chemotherapeutic Bone Cements

Abstract

Chemotherapeutic bone cements can both stabilize the bone fractures as well as deliver chemotherapy agents directly to the bone metastatic site and adjacent soft tissue tumors. This study evaluated the in vitro elution and flexural properties of Vertebroplastic™ and Confidence Ultra™ bone cements (Depuy Spine Inc., Raynham, Mass., USA) containing methotrexate. In vitro elution was measured by placing bone cement specimens containing 4 different methotrexate amounts in 20 ml saline, and the methotrexate elution was measured at regular intervals for 672 h. The flexural properties of bone cement containing 2 different initial methotrexate amounts after storage in physiological saline were measured using a 3-point bending test. The drug elution rate depended on the initial methotrexate amount added and the type of bone cement used. The relationship between the initial drug amount added and the drug elution rate was not linear. Methotrexate elution decreased the flexural modulus and strength of specimens; this decrease was not proportional to the initial amount of methotrexate added. The results show that bone cements are well suited for use with chemotherapy agents. However, the elution and mechanical properties of each bone cement-drug amount combination should be thoroughly quantified in vitro before using such a combination in a clinical setting.

In situ forming implants for local chemotherapy and hyperthermia of bone tumors

“…Using two commercially available acrylic bone cements (Vertebroplastic TM and Confidence Ultra TM ) loaded with methotrexate at varying amounts, the same authors found a correlation between MTX elution and a decrease in flexural modulus as well as cement strength. This decrease was not proportional to the initial amount of MTX added [210]. Different concentrations of DOX and pamidronate were incorporated within surgical Simplex™ acrylic cement in order to study their influence on cement mechanical properties and their in vitro release.…”

Regulation of The antibiotic Elution Profile from Tricalcium Phosphate Bone Cement by Addition of Bioactive Glass

“…However, fabrication of controlled drug release system based on CPCs is critical. Where either very low or accelerated drug elution is undesirable, so that the drug should be release with a rate that achieve a disease treatment [22]. Accordingly, the drug delivery system can be tailored by adjusting porosity, particle size, incorporation of other materials to obtain composites etc.…”

PMMA Bone Cement Composite Functions as an Adjuvant Chemotherapeutic Platform for Localized and Multi‐Window Release during Bone Reconstruction

“…Figure 1 depicts an overview of the analyses carried out in this work. While prior studies have investigated antineoplastic drug-laden PMMA, [30][31][32][33][34][35][36][37][38][39][40] our work is the first to evaluate release kinetics and material/structural properties of DOX-laden PMMA bone cement and to devise a localized adjuvant chemotherapeutic delivery platform to be integrated into temporary spacers for use in the Masquelet technique, offering a potential adjunct to supplement systemic adjuvant chemotherapy. The goal of this study is to evaluate the feasibility of using a PMMA composite chemotherapeutic delivery system for temporary spacer applications for bone reconstruction procedures that is capable of releasing its entire payload and meets mechanical standards.…”