Evaluation of Encapsulated Eugenol by Chitosan Nanoparticles on the aggressive model of rheumatoid arthritis

Jabbari, Nazanin; Eftekhari, Zohre; Roodbari, Nasim Hayati; Parivar, Kazem

doi:10.1016/j.intimp.2020.106554

Cited by 41 publications

(15 citation statements)

References 25 publications

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“…As mentioned before, TNF-α induces impaired function of Treg cells via FOXP3 and inhibits their protective role in the synovium, while TNF receptor type II (TNFRII), the receptor type that mediated the anti-inflammatory effects of TNF, has been demonstrated to participate in maintaining the stable expression of FOXP3, suggesting that the potential mechanism of anti-TNF agent in RA treatment may be attributed to the expansion of TNFRII + Treg cells (Santinon et al, 2020). Moreover, because oxidative stress and RA are closely related pathologically, antioxidant therapy has also been considered as a prospective strategy of RA (Khojah et al, 2016;Jabbari et al, 2020). In addition, the Hippo-Yes-associated protein (YAP) signaling pathway regulates the expression of target genes to affect a series of physiological activities through responding to other intracellular and extracellular signals, consequently playing important roles in cell proliferation, differentiation, and apoptosis, which suggests its indispensable impacts on osteogenesis and immune regulation (Liu et al, 2016;Xiang et al, 2018;Wang et al, 2019).…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Current Understanding of Osteoimmunology in Certain Osteoimmune Diseases

Zhou

et al. 2021

Front. Cell Dev. Biol.

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The skeletal system and immune system seem to be two independent systems. However, there in fact are extensive and multiple crosstalk between them. The concept of osteoimmunology was created to describe those interdisciplinary events, but it has been constantly updated over time. In this review, we summarize the interactions between the skeletal and immune systems in the co-development of the two systems and the progress of certain typical bone abnormalities and bone regeneration on the cellular and molecular levels according to the mainstream novel study. At the end of the review, we also highlighted the possibility of extending the research scope of osteoimmunology to other systemic diseases. In conclusion, we propose that osteoimmunology is a promising perspective to uncover the mechanism of related diseases; meanwhile, a study from the point of view of osteoimmunology may also provide innovative ideas and resolutions to achieve the balance of internal homeostasis.

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Section: Rheumatoid Arthritismentioning

confidence: 99%

Current Understanding of Osteoimmunology in Certain Osteoimmune Diseases

Zhou

et al. 2021

Front. Cell Dev. Biol.

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“…Jabbari and colleagues investigated the effects of encapsulated eugenol with chitosan nanoparticles on a neonatal CIA-rat model [81]. Eugenol-entrapped chitosan nanoparticles (Eug-CNPs) were prepared through the solvent dispersion method, and evaluated for anti-oxidative stress (malondialdehyde for assessment of lipid peroxidation) by an assay kit, FOXO3 protein as an antioxidant up-regulating by western blotting, and expression of the TGF-β and CCL2/MCP-1 genes by real-time PCR evaluation, supported by a cartilage histopathology analysis.…”

Section: Nano-formulation Of Isolated Compoundsmentioning

confidence: 99%

Antiarthritic Activities of Herbal Isolates: A Comprehensive Review

Jain¹,

Vaidya

Gupta

et al. 2021

Coatings

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Numerous plant isolates with therapeutic properties, such as antimicrobial, antiinflammatory, antiviral, antimalarial, antiarthritic (AA), hepatoprotective, cardiotonic, and so forth, are reported in the literature. Usually, medicinal plants are widely used, and assumed to be safe and cheaper alternatives to chemically synthesized drugs. However, they are not regulated for potency and purity, and thus care must be taken for their safe use. In this review, we aimed to compile all of the herbal isolates possessing AA properties, including alkaloids (montanine, 3-acetylaconitine, sanguinarine, jatrorrhizine hydrochloride, and piperine), terpenoids (eugenol, nimbolide, bartogenic acid, cannabidiol, and curcumin), and flavonoids (quercetin, resveratrol, kaempferol, chebulanin, ellagic acid, rosmarinic acid, gallic acid, chlorogenic acid, ferulic acid, and brazilin). These isolates act through numerous pharmacological mechanisms such as inhibiting cytokines, chemokines, or matrix metalloproteinase, etc., to demonstrate AA activity. Animal models utilized for assessing the AA properties of these isolates, including adjuvant-induced arthritis mouse models, are also discussed. Furthermore, nanotechnology-based approaches to deliver these isolates are also reviewed, which have shown improved therapeutic efficacy of isolated compounds.

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“…Sodium alginate has been used to prepare Ibuprofen microbeads with a variety of physicochemical properties [147]. Encapsulated Eugenol with Chitosan Nanoparticle has been able to alleviate the symptoms of joint inflammation, synovial hyperplasia, and cartilage damage caused by RA in rats ( Figure 5) [148]. Chitosan improved Leflunomide's anti-arthritic effect when used as a coating in an oral nanosystem in an RA-induced rat model.…”

Section: Advantages and Applications Of Various Marine-derived Compoumentioning

confidence: 99%

mentioning

confidence: 99%

Marine-Derived Biologically Active Compounds for the Potential Treatment of Rheumatoid Arthritis

et al. 2020

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Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease with a prevalence rate of up to 1% and is significantly considered a common worldwide public health concern. Commercially, several traditional formulations are available to treat RA to some extent. However, these synthetic compounds exert toxicity and considerable side effects even at lower therapeutic concentrations. Considering the above-mentioned critiques, research is underway around the world in finding and exploiting potential alternatives. For instance, marine-derived biologically active compounds have gained much interest and are thus being extensively utilized to confront the confines of in practice counterparts, which have become ineffective for 21st-century medical settings. The utilization of naturally available bioactive compounds and their derivatives can minimize these synthetic compounds’ problems to treat RA. Several marine-derived compounds exhibit anti-inflammatory and antioxidant properties and can be effectively used for therapeutic purposes against RA. The results of several studies ensured that the extraction of biologically active compounds from marine sources could provide a new and safe source for drug development against RA. Finally, current challenges, gaps, and future perspectives have been included in this review.

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Evaluation of Encapsulated Eugenol by Chitosan Nanoparticles on the aggressive model of rheumatoid arthritis

Cited by 41 publications

References 25 publications

Current Understanding of Osteoimmunology in Certain Osteoimmune Diseases

Current Understanding of Osteoimmunology in Certain Osteoimmune Diseases

Antiarthritic Activities of Herbal Isolates: A Comprehensive Review

Marine-Derived Biologically Active Compounds for the Potential Treatment of Rheumatoid Arthritis

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