Evaluation of endometrial biomarkers for semi-invasive diagnosis of endometriosis

Kyama, Cleophas; Mihályi, Attila; Gevaert, Olivier; Waelkens, Etienne; Stella, Péter; Plas, Raf Van de; Meuleman, Christel; Moor, Bart De; D’Hooghe, Thomas

doi:10.1016/j.fertnstert.2010.06.084

Cited by 37 publications

(27 citation statements)

References 31 publications

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“…Through exploitation of multiple modalities of endometrial assessment, in both normal and abnormal endometrium, methods such as thin-layer chromatography of uterine secretions (29)(30)(31)(32), immunohistochemistry (33,34), differential display and reverse transcription-polymerase chain reaction (35), DNA microarray (7,(36)(37)(38)(39), microRNA studies (40)(41)(42), and proteomic analysis (43)(44)(45) have added to the complexity of our understanding of endometrial receptivity.…”

mentioning

confidence: 99%

Assessment of endometrial receptivity

Lessey

2011

Fertility and Sterility

217

122

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confidence: 99%

Assessment of endometrial receptivity

Lessey

2011

Fertility and Sterility

217

122

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“…Enzymes of the GST family are involved in the breakdown of xenobiotic 2,3,7,8-tetrachlorodibenzo-p-dioxin. Dioxin is a carcinogen and a teratogen compound, and the GSTM1 null mutation is associated with development of cancer due to environmental exposure and a lack of the detoxification enzyme (Kyama et al, 2011). Dioxin has multiple effects on the human reproductive system, including increasing the risk of developing endometriosis.…”

Section: Detoxification Enzymesmentioning

confidence: 99%

“…Additionally, it is a major cause of recurrent abortion, probably caused by the presence of abnormal auto-antibodies (Nothnick, 2001). Although it exhibits benign metastatic features, the condition also shows malignant behavior such as aggressive growth and tissue invasion (Kyama et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Endometrial cells with genetic polymorphisms may respond to local signals and then escape apoptotic processes. The products of these abnormal cells stimulate tissue invasion and induce inflammatory response (Kyama et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…New methods based on genetic markers related to endometriosis are necessary for faster and more accurate diagnosis, including identification of patients who are at high risk of developing the disease (Kyama et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Genetic polymorphisms in patients with endometriosis: an analytical study in Goiânia (Central West of Brazil)

Silva

Moura

2016

Genet. Mol. Res.

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ABSTRACT. In healthy women, intra-and extracellular controls prevent the attachment and proliferation of ectopic endometrial cells. During endometriosis, abnormalities in these control mechanisms permit the survival of endometrial cells, their subsequent attachment to the peritoneal cavity, and disease progression. These abnormal cells cause invasion of tissues and induce an inflammatory response. Several genetic, immunological, and environmental factors contribute to this complex process. In this study we examined 6 polymorphisms for 6 different genes (p53; estrogen receptor β; progesterone receptor; GSTM1; GSTT1; CYP1A1). We obtained polymorphic genotype frequencies of all genes for 50 patients and analyzed them using the Fisher exact test or G test. Initially, we analyzed the genes in groups of 2, followed by 3. We found a significant association between polymorphisms in 6 pairs of genes (p53-ERβ showed 5.9-times higher frequency in the experimental group, p53-GSTM1 showed 2.39 times higher, 65.5% patients showed p53-CYP1A1 polymorphism, ERβ-PROGINS showed 3.0-times higher frequency, while 31.25% patients showed GSTM1-PROGINS and GSTT1-CYP1A1 polymorphism). Positive results were found in 15 situations when genes were analyzed in groups of 3; the most significant result corresponded to polymorphisms of p53, ERβ and GSTM1 seen in 20%; PROGINS, ERβ and GSTM1 in 18%; and p53, ERβ and PROGINS in 12% patients. The results indicate that the presence of polymorphisms in more than one endometriosis-related gene is associated with onset of disease and progression. Future studies should focus on these genes to understand their inter-relationships and explore the possibility of developing new diagnostic techniques based on molecular markers.

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Endometrial biomarkers for the non-invasive diagnosis of endometriosis

Gupta

Hull

Fraser

et al. 2016

Cochrane Database of Systematic Reviews

101

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We could not statistically evaluate most of the biomarkers assessed in this review in a meaningful way. In view of the low quality of most of the included studies, the findings of this review should be interpreted with caution. Although PGP 9.5 met the criteria for a replacement test, it demonstrated considerable inter study heterogeneity in diagnostic estimates, the source of which could not be determined. Several endometrial biomarkers, such as endometrial proteome, 17βHSD2, IL-1R2, caldesmon and other neural markers (VIP, CGRP, SP, NPY and combination of VIP, PGP 9.5 and SP) showed promising evidence of diagnostic accuracy, but there was insufficient or poor quality evidence for any clinical recommendations. Laparoscopy remains the gold standard for the diagnosis of endometriosis, and using any non-invasive tests should only be undertaken in a research setting. We have also identified a number of biomarkers that demonstrated no diagnostic value for endometriosis. We recommend that researchers direct future studies towards biomarkers with high diagnostic potential in good quality diagnostic studies.

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Evaluation of endometrial biomarkers for semi-invasive diagnosis of endometriosis

Cited by 37 publications

References 31 publications

Assessment of endometrial receptivity

Assessment of endometrial receptivity

Genetic polymorphisms in patients with endometriosis: an analytical study in Goiânia (Central West of Brazil)

Endometrial biomarkers for the non-invasive diagnosis of endometriosis

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