Evaluation of Eosinophilic Cationic Protein and Some Immunological Markers in Patients Infected with Scabies

Abstract

The current study is trying to identify some effects of scabies on some vital indicators such as (ECP, IgE, MCP-1 and IL-17). The results showed that levels of ECP has significant increase (P<0.05 (9569.3 ±256.10 pg /ml), (9872.9± 260.50) respectively in comparison with the control group (7665.2 ± 385.72 pg /ml), (7834.1± 251.43 pg /ml) respectively, The result proved that there was the significant increase (P (9721.1 ±181.15 pg /ml), (7749.7± 226.75) respectively in concentration of (ECP) in patients with S. scabiei and total healthy individuals. The levels of IgE had significant increase (P (284.8 ±34.05 IU / ml), (249.85± 13.682 IU /ml) respectively in comparison with the control group (119.5 ± 11.24 IU /ml), (108.77± 8.3 IU /ml) respectively. The result indicate that there was significant increase (P (267.134 ±18. 334 IU /ml), (114.13± 6.94 IU /ml) respectively in concentration of (IgE) in total patients infected with S. scabiei and total control group. The levels of MCP-1 has significant increase (P (271.76 ±29. 88 pg /ml), (246.983± 27.57 pg /ml) respectively in comparison with the control group (153. 27 ± 21.071pg/ml), (154.67± 22.973 pg /ml) respectively, Also it revealed the significant increase (P (259.29±20. 22 pg /ml), (153. 97± 15.21 pg /ml) respectively in concentration of (MCP-1) in S. scabiei patients and total healthy individuals. IL-17 had significant increase (P (16.318 ±0. 71 pg /ml), (16.847± 0.58 pg /ml) respectively in comparison with the control group (5. 6009 ±0. 45 pg/ml), (5.2023± 0. 35 pg /ml) respectively. The current study shows that there was significant increase (P (16.583±0. 45pg /ml), (16.4016± 0.28 pg / ml) respectively in concentration of (IL-17) in total patients infected with S. scabiei and total healthy individuals. The levels of IL-2 had significant increase (P (21.14 ±0. 8081 pg /ml), (21.800± 1.0644 pg / ml) respectively in comparison with total healthy individuals (7. 447 ±0. 2422 pg/ml), (7.7235± 0. 1716 pg /ml) respectively, Also it revealed the significant increase (P (20.972±0. 6626pg /ml), (7.5853± 0.1480 pg /ml) respectively in concentration of (IL-2) in total patients infected with S. scabiei and total control group. Conclusions: the results indicate that infection of scabies influences on the human immunity represented by the ECP, IgE MCP-1 and IL-17 in patients infected with scabies and may be used as good biomarkers in detection of scabies.

Study the Role of Eosinophilic Cationic Protein, Copper and Iron in Women Infected with Trichomonas vaginalis Parasite

“…As compared to those in the control group, patients with T.vaginalis infections had significantly lower copper levels. Copper, zinc, and magnesium are crucial for growth and development in growing children and play a crucial part in the metabolism and physiology of the human body, so these results may be caused by the virulence factors of this parasite (16,17). These results are in line with those of Uwah et al (18), who found that patients with parasite infections had lower serum levels of zinc, copper, and magnesium than did the control group.…”

“…In this investigation, samples were compared using the T-test with Graph-Pad Prism version 10 software. A p-value of 0.05 or less is regarded as statistically significant (14,15,16).…”

Serum thymus and activation‐regulated chemokine levels before and after treatment for pruritic scabies

“…Scabies commonly occurs in elderly patients, and classic scabies can resemble Th2 immunity‐related dermatological diseases, such as atopic dermatitis (AD) and prurigo nodularis (PN) 1 . Elevated serum immunoglobulin E (IgE) levels have been reported during scabies infections, which reduced after the scabies was treated 2,3,4 . Here, we report, for the first time, a case of pruritic scabies, involving elevated serum thymus and activation‐regulated chemokine (TARC) levels, which decreased after the scabies was treated.…”

“…1 Elevated serum immunoglobulin E (IgE) levels have been reported during scabies infections, which reduced after the scabies was treated. 2,3,4 Here, we report, for the first time, a case of pruritic scabies, involving elevated serum thymus and activation-regulated chemokine (TARC) levels, which decreased after the scabies was treated.…”

Interleukin 18 and interleukin 22 as important immune markers in patients with tuberculosis

“…A statistical package (Statistical Package for Social Sciences, version 20, IBM, and Armonk, New York) was used to collect and analyze the data [17,18]. A mean and standard deviation were used to summarize the quantitative data; numbers and percentages were used to summarize qualitative data, correlation was used to determine correlations, and a P-value<0.05 was considered significant [19,20].…”