Evaluation of epithelial transport and oxidative stress protection of nanoengineered curcumin derivative-cyclodextrin formulation for ocular delivery

Maharjan, Pooja; Jin, Minki; Kim, Daseul; Yang, Jong In; Maharjan, Anjila; Shin, Meong Cheol; Cho, Kwan Hyung; Kim, Man Su; Min, Kyung Up

doi:10.1007/s12272-019-01154-9

Cited by 29 publications

(12 citation statements)

References 42 publications

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“…The paraffin sections were used for the staining with hematoxylin and eosin (H&E) reagents to assess any tissue toxicity. As reported previously, 27 after the staining with hematoxylin solution, the slides were serially washed with absolute ethanol and then 95% ethanol. The slides were counterstained by the eosin solution and then washed with water, 8095% ethanol, absolute ethanol and xylene.…”

Section: Histological Analysismentioning

confidence: 99%

<p>ICG-Loaded PEGylated BSA-Silver Nanoparticles for Effective Photothermal Cancer Therapy</p>

Park¹,

Lee²,

Amatya³

et al. 2020

IJN

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Purpose Indocyanine green (ICG), a near infrared (NIR) dye clinically approved in medical diagnostics, possesses great heat conversion efficiency, which renders itself as an effective photosensitizer for photothermal therapy (PTT) of cancer. However, there remain bottleneck challenges for use in PTT, which are the poor photo and plasma stability of ICG. To address these problems, in this research, ICG-loaded silver nanoparticles were prepared and evaluated for the applicability as an effective agent for photothermal cancer therapy. Methods and Results PEGylated bovine serum albumin (BSA)-coated silver core/shell nanoparticles were synthesized with a high loading of ICG (“PEG-BSA-AgNP/ICG”). Physical characterization was carried out using size analyzer, transmission electron microscopy, and Fourier transform infrared spectrophotometry to identify successful preparation and size stability. ICG-loading content and the photothermal conversion efficiency of the particles were confirmed with inductively coupled plasma mass spectrometry and laser instruments. In vitro studies showed that the PEG-BSA-AgNP/ICG could provide great photostability for ICG, and their applicability for PTT was verified from the cellular study results. Furthermore, when the PEG-BSA-AgNP/ICG were tested in vivo, study results exhibited that ICG could stably remain in the blood circulation for a markedly long period (plasma half-life: 112 min), and about 1.7% ID/g tissue could be accumulated in the tumor tissue at 4 h post-injection. Such nanoparticle accumulation in the tumor enabled tumor surface temperature to be risen to 50°C (required for photo-ablation) by laser irradiation and led to successful inhibition of tumor growth in the B16F10 s.c. syngeneic nude mice model, with minimal systemic toxicity. Conclusion Our findings demonstrated that PEG-BSA-AgNPs could serve as effective carriers for delivering ICG to the tumor tissue with great stability and safety.

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Section: Histological Analysismentioning

confidence: 99%

<p>ICG-Loaded PEGylated BSA-Silver Nanoparticles for Effective Photothermal Cancer Therapy</p>

Park¹,

Lee²,

Amatya³

et al. 2020

IJN

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“…After the calibration of instrument was performed using indium, samples in an aluminum pan were analyzed at the heat rate of 10 • C/min under nitrogen gas at 20 mL/min. Furthermore, the particles were analyzed by an X-ray diffractogram (XRD) to get any crystalline characteristics [32]. The XRD instrument, Ultima IV diffractometer (Rigaku, Japan), was set at the voltage at 45 kV, and the current at 30 mA, scanning the diffraction angle of samples between 0 • and 90 • .…”

Section: Measurements Of Particle Properties By Dynamic Scanning Calomentioning

confidence: 99%

Synergistic Effect of Growth Factor Releasing Polymeric Nanoparticles and Ultrasound Stimulation on Osteogenic Differentiation

et al. 2021

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Mesenchymal stem cells (MSCs) have been extensively used in the tissue regeneration therapy. Ex vivo therapy with well-differentiated osteogenic cells is known as an efficient treatment for musculoskeletal diseases, including rheumatoid diseases. However, along with its high cost, the current therapy has limitations in terms of restoring bone regeneration procedures. An efficient process for the cell differentiation to obtain a large number of functionalized osteogenic cells is necessary. Therefore, it is strongly recommended to develop strategies to produce sufficient numbers of well-differentiated osteogenic cells from the MSCs. In general, differentiation media with growth factors have been used to facilitate cell differentiation. In the present study, the poly (lactic-co-glycolic acid) (PLGA) nanoparticles incorporating the growth factors were included in the media, resulting in releasing growth factors (dexamethasone and β-glycerophosphate) in the media in the controlled manner. Stable growth and early differentiation of osteogenic cells were achieved by the PLGA-based growth factor releasing system. Moreover, low intensity pulsed ultrasound was applied to this system to induce cell differentiation process. The results revealed that, as a biomarker at early stage of osteogenic cell differentiation, Lamin A/C nuclear protein was efficiently expressed in the cells growing in the presence of PLGA-based growth factor reservoirs and ultrasound. In conclusion, our results showed that the ultrasound stimulation combined with polymeric nanoparticles releasing growth factors could potentially induce osteogenic cell differentiation.

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“…After THC encapsulation with hydroxypropyl-cyclodextrins, drug solubility and corneal and retinal epithelial permeability got increased. Increased bioavailability is associated with enhanced antioxidant activity in the ocular epithelial cells, which is responsible for oxidative stress-protective effects in rabbit cornea tissues [ 63 ].…”

Section: Functions Of Reduced Metabolites Of Curcuminmentioning

confidence: 99%

Reductive metabolites of curcumin and their therapeutic effects

Pandey

Chaturvedi

Mishra

et al. 2020

Heliyon

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Evaluation of epithelial transport and oxidative stress protection of nanoengineered curcumin derivative-cyclodextrin formulation for ocular delivery

Cited by 29 publications

References 42 publications

<p>ICG-Loaded PEGylated BSA-Silver Nanoparticles for Effective Photothermal Cancer Therapy</p>

<p>ICG-Loaded PEGylated BSA-Silver Nanoparticles for Effective Photothermal Cancer Therapy</p>

Synergistic Effect of Growth Factor Releasing Polymeric Nanoparticles and Ultrasound Stimulation on Osteogenic Differentiation

Reductive metabolites of curcumin and their therapeutic effects

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