Evaluation of equine cecal motility by ausculation, ultrasonography and electrointestinography after jejunocecostomy

Sasaki, Naoki; Murata, Aya; Lee, Inhyung; Yamada, Hiroyuki

doi:10.1016/j.rvsc.2007.04.009

Cited by 17 publications

(23 citation statements)

References 26 publications

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“…This highlights the poor sensitivity of gastrointestinal borborygmi as a sole clinical marker of gastrointestinal motility. These results are consistent with those of a previous study that showed poor agreement of auscultation scores with electrointestinography [24]. Thus, clinicians using lidocaine, butorphanol, and ketamine in combination should carefully monitor fecal output and be aware of the potential for colic in these patients.…”

Section: Discussionsupporting

confidence: 91%

Systemic and anti-nociceptive effects of prolonged lidocaine, ketamine, and butorphanol infusions alone and in combination in healthy horses

et al. 2014

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BackgroundProlonged drug infusions are used to treat horses with severe signs of pain, but can be associated with altered gastrointestinal transit. The purpose of this study was to determine the effects of prolonged constant rate infusions (CRI) of lidocaine (L), butorphanol (B), and ketamine (K) alone and in combination on gastrointestinal transit, behavior, and thermal nociceptive threshold in healthy horses.MethodsEight healthy adult horses were used in a randomized, cross-over, blinded, prospective experimental trial. Interventions were saline, L, K, B, LK, LB, BK, and LBK as an intravenous CRI for 96 hours. Drugs were mixed or diluted in saline; following a bolus, CRI rate was 0.15mL/kg/hr with drug doses as follows: L – 1.3 mg/kg then 3 mg/kg/hr; B – 0.018 mg/kg then 0.013 mg/kg/hr; K – 0.55 mg/kg then 0.5 mg/kg/hr. Two-hundred plastic beads were administered intragastrically by nasogastric tube immediately prior to the bolus. Feces were collected every 2 hours, weighed, and beads manually retrieved. Behavior was scored every 2 hours, vital parameters every 6 hours, and thermal nociceptive threshold every 12 hours for 96 hours. Drug concentrations in the LBK solution were tested every 6 hours for 72 hours.ResultsFour of 64 trials (3 LBK, 1 BK) were discontinued early due to signs of abdominal discomfort. There were no apparent differences between groups in vital parameters or thermal threshold. Transit time was delayed for LB and LBK with a corresponding decrease in fecal weight that was most severe in the final 24 hours of infusion. Significant changes in behavior scores, vital parameters, or thermal threshold were not observed. The concentration of each drug in the combined solution declined by less than 31% over the sampling period.ConclusionsDrug combinations containing butorphanol cause an apparent delay in gastrointestinal transit in healthy horses without substantially affecting somatic nociception at the doses studied. Combinations of lidocaine and ketamine may have less impact on gastrointestinal transit than infusions combined with butorphanol. Further work is needed to determine the effects of these drugs in painful or critically ill patients.

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Section: Discussionsupporting

confidence: 91%

Systemic and anti-nociceptive effects of prolonged lidocaine, ketamine, and butorphanol infusions alone and in combination in healthy horses

et al. 2014

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“…This study has produced baseline data on the normal motility of the large intestine in stabled and pastured horses. Frequency of caecal contractions were lower than those reported in other studies (Freeman and England 2001; Sasaki et al . 2008).…”

Section: Discussioncontrasting

confidence: 84%

“…Ultrasound has been shown to be useful for assessment of motility (Freeman and England 2001; Mitchell et al . 2005; Sasaki et al . 2008).…”

Section: Discussionmentioning

confidence: 99%

Investigation of the effect of pasture and stable management on large intestinal motility in the horse, measured using transcutaneous ultrasonography

Williams

Tucker

Green

et al. 2011

Equine Veterinary Journal

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SummaryReason for performing study: Management regimes have been identified as risk factors for equine intestinal motility disorders. However, it is not known how management factors affect gastrointestinal motility. Hypothesis: Large intestinal motility was similar in horses on a stabled and a pastured management regime. Objective: To investigate the effect of 2 different management regimes on large intestinal motility assessed with ultrasonography. Methods: A within-subjects crossover design was used to compare large intestinal motility between a stabled and a pastured regime in 16 working horses. Group A was managed under a standardised stabled regime throughout the study.

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“…Another methodology attracting increased attention is electrointestinography. Here, percutaneous electrical potentials of the intestine (including the small intestine and caecum) are recorded and analysed (Sasaki et al 2008), which can provide information on intestinal motility, including the effects of pharmacological agents (Sasaki et al 2005a). This approach should be investigated further in the horse since it has a great potential for noninvasively studying intestinal myoelectrical activity under a variety of situations.…”

Section: Electrophysiologymentioning

confidence: 99%

Equine gastrointestinal motility research: Where we are and where we need to go

Hudson¹,

Merritt²

2008

Equine Veterinary Journal

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Equine gastrointestinal motility is a central issue in cases of equine colic, post operative convalescence and alimentary conditions encountered in practice. There are significant syndromes of intestinal dysmotility in the horse such as obstructive disorders and post operative ileus that are still poorly understood. This review describes the various areas of research that aim to elucidate the pathogenesis of intestinal hypo- or hypermotility by research methods, which include studies at the cellular level, and those that employ in vitro or in vivo techniques of evaluating the physiology and mechanical means of ingesta transit through the alimentary tract. The review discusses future directions for studies which will hopefully lead to better understanding and appropriate measures for diagnosis, therapy and prevention of ileus and other motility disorders.

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Evaluation of equine cecal motility by ausculation, ultrasonography and electrointestinography after jejunocecostomy

Cited by 17 publications

References 26 publications

Systemic and anti-nociceptive effects of prolonged lidocaine, ketamine, and butorphanol infusions alone and in combination in healthy horses

Systemic and anti-nociceptive effects of prolonged lidocaine, ketamine, and butorphanol infusions alone and in combination in healthy horses

Investigation of the effect of pasture and stable management on large intestinal motility in the horse, measured using transcutaneous ultrasonography

Equine gastrointestinal motility research: Where we are and where we need to go

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