Evaluation of erythrocyte deformability in pre-menopausal and post-menopausal women

Gelmini, G; Delsignore, R; Coiro, V.

doi:10.1016/0378-5122(87)90010-7

Cited by 11 publications

(7 citation statements)

References 17 publications

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“…Advancing donor age is associated with multiple deleterious changes in RBC properties, including increased fragility (Detraglia et al 1974;Bowdler et al 1981), morphological changes (Bowdler et al 1981), and decreases in membrane fluidity and deformability (Reid et al 1976;Hegner et al 1979;Gelmini et al 1987Gelmini et al , 1989. Among these, the age-associated decline in RBC antioxidant capacity (Glass & Gershon, 1984;Gershon & Gershon, 1988;Gil et al 2006;Rizvi & Maurya, 2007;Chaleckis et al 2016) is likely one of the most detrimental given that RBCs can generate substantial amounts of reactive oxygen/nitrogen species (Johnson et al 2005;Cimen, 2008;Rifkind & Nagababu, 2013;Kuhn et al 2017), which cause oxidative damage that has been clearly linked to decreased RBC deformability (Haest et al 1977;Wang et al 1999;Tsantes et al 2006;Rifkind & Nagababu, 2013;Mohanty et al 2014;Xiong et al 2017).…”

Section: Potential Causes Of Decreased Rbc Deformability With Advancimentioning

confidence: 99%

“…Although the underlying mechanisms of this impairment in RBC ATP release are unknown, one possibility is the age-associated decrease in RBC membrane fluidity and deformability (Reid et al 1976;Hegner et al 1979;Gelmini et al 1987Gelmini et al , 1989. In this context, it has been demonstrated that acute, pharmacologically induced increases or decreases in RBC deformability produce parallel changes in deoxygenation-induced ATP release from RBCs of young healthy donors (Thuet et al 2011).…”

Section: Introductionmentioning

confidence: 99%

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Reduced deformability contributes to impaired deoxygenation‐induced ATP release from red blood cells of older adult humans

Racine

Dinenno

2019

The Journal of Physiology

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Red blood cells (RBCs) release ATP in response to deoxygenation, which can increase blood flow to help match oxygen supply with tissue metabolic demand. r This release of ATP is impaired in RBCs from older adults, but the underlying mechanisms are unknown. r In this study, improving RBC deformability in older adults restored deoxygenation-induced ATP release, whereas decreasing RBC deformability in young adults reduced ATP release to the level of that of older adults. r In contrast, treating RBCs with a phosphodiesterase 3 inhibitor did not affect ATP release in either age group, possibly due to intact intracellular signalling downstream of deoxygenation as indicated by preserved cAMP and ATP release responses to pharmacological G i protein activation in RBCs from older adults. r These findings are the first to demonstrate that the age-related decrease in RBC deformability is a primary mechanism of impaired deoxygenation-induced ATP release, which may have implications for treating impaired vascular control with advancing age.

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Section: Potential Causes Of Decreased Rbc Deformability With Advancimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Reduced deformability contributes to impaired deoxygenation‐induced ATP release from red blood cells of older adult humans

Racine

Dinenno

2019

The Journal of Physiology

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“…Some of the determinants, i.e., BV (especially at low shear rate), PV, AI, DI and RI, were considered of great clinical significance [7,11,30,46]. Rosenson et al [30] pointed out changes in plasma viscosity could be a sensitive indicator of the effect of hormone replacement therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Rosenson et al [30] pointed out changes in plasma viscosity could be a sensitive indicator of the effect of hormone replacement therapy. DI, a determinant related to the mechanic properties of erythrocyte, was reported to diminish during menopause [11]. Another relevant aspect, erythrocyte aggregation, revealed to be associated with degree of hemoglobin oxygenation [40] and mirocirculation [20], is increased in menopausal women.…”

Section: Discussionmentioning

confidence: 99%

The hemorheological safety of pulsed electromagnetic fields in postmenopausal women with osteoporosis in southwest China: A randomized, placebo controlled clinical trial

Liu

Yang

et al. 2013

Clinical Hemorheology and Microcirculation

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Apart from medications, pulsed electromagnetic fields (PEMFs) are used to treat osteoporosis nowadays. However studies on hemorheological safety of PEMFs were scarce. This randomized, placebo controlled clinical trial assessed whether PEMFs could lead to significant hemorheological changes. Fifty-five postmenopausal women were randomly assigned to receive placebo or PEMFs. Venous blood samples were collected at baseline and after treatment to measure 14 hemorheological determinants. Independent samples t-test, paired samples t-test and chi-squared tests were performed respectively. Relationships between variables were determined by Pearson correlation analysis. Multiple linear stepwise regression analysis was used to explore predictors of selected determinants. No significant differences existed between the placebo and PEMFs groups for any of the 14 hemorheological determinants (P > 0.05) or the percentage of patients with hemorheological determinant within reference range (P > 0.05). Hematocrit was found to be correlated with BMI (P = 0.007). The most significant predictor of blood reduced viscosity at low shear rate was blood viscosity at low shear rate. And blood reduced viscosity at high shear rate was the most important predictor of plasma viscosity. These results showed, compared with placebo, PEMFs treatment of postmenopausal osteoporosis was not associated with adverse changes in hemorheological determinants, which may contribute to venous thromboembolism.

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“…Another study of arteriosclerosis changes in men and women showed a significant rise in VIIc but fibrinogen begins to rise in the 5th decade of life in the women group only. Gelmini et al [68] studied pre-and postmenopausal changes in a group of 20 women (10 each). The postmenopausal group showed elevated values of fibrinogen, triglycerides, uric acid, fasting glucose and lowered values of HDL cholesterol and blood filterability.…”

Section: Menopausal Changesmentioning

confidence: 99%

Hemorheological Changes during Human Aging

Ajmani

Rifkind²

1998

Gerontology

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Various researchers have reported an association of hemorheological, hematological and metabolic changes with human aging. In this article an attempt has been made to review the present understanding of hemorheological changes and their probable role in the development of certain disorders/diseases during aging. The rise in fibrinogen, blood viscosity, plasma viscosity, red cell rigidity, fibrin degradation products and early activation of the coagulation system are some of the most prominent findings. It is generally agreed that a rise in blood viscosity factors leads to a state of hypoperfusion which results in impaired microcirculation. The cumulative effect of these changes appears in the form of a disturbed blood flow profile in older subjects leading to the development or aggravation of various circulatory disorders. Many studies indicate that hemorheological parameters that change in a number of diseases prevalent during aging include hypertension, stroke, diabetes. In addition correlations found between hemorheological parameters in the aged and decrements in certain cognitive functions and behavioral patterns suggest that hemorheological changes contribute to nonclinical aging changes.

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Evaluation of erythrocyte deformability in pre-menopausal and post-menopausal women

Cited by 11 publications

References 17 publications

Reduced deformability contributes to impaired deoxygenation‐induced ATP release from red blood cells of older adult humans

Reduced deformability contributes to impaired deoxygenation‐induced ATP release from red blood cells of older adult humans

The hemorheological safety of pulsed electromagnetic fields in postmenopausal women with osteoporosis in southwest China: A randomized, placebo controlled clinical trial

Hemorheological Changes during Human Aging

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