Evaluation of Escherichia coli as an indicator for antimicrobial resistance in Salmonella recovered from the same food or animal ceca samples

Nyirabahizi, Epiphanie; Tyson, Gregory H.; Dessai, Uday; Zhao, Shaohua; Kabera, Claudine; Crarey, Emily; Womack, Niketta; Crews, Mary Katherine; Strain, Errol; Tate, Heather

doi:10.1016/j.foodcont.2020.107280

Cited by 32 publications

(29 citation statements)

References 24 publications

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“…Horizontal gene transfer has promoted the diffusion of antibiotic resistance genes among this species and other commensals [18], particularly in environments such as the intestinal tract, where the species diversity and bacterial population density are large. Therefore, E. coli has been used as a sentinel microorganism for antimicrobial resistance surveillance, especially in the case of the β-lactams [19].…”

Section: Antimicrobial Resistance Trends In E Colimentioning

confidence: 99%

Escherichia coli as Commensal and Pathogenic Bacteria among Food-Producing Animals: Health Implications of Extended Spectrum β-Lactamase (ESBL) Production

Ramos

Silva

Dapkevicius

et al. 2020

Animals

153

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Escherichia coli are facultative, anaerobic Gram-negative rods with many facets. Within resistant bacterial populations, they play an important ecological role and can be used as a bioindicator of antimicrobial resistance. All animal species used for food production, as well as humans, carry E. coli in their intestinal tracts; plus, the genetic flexibility and adaptability of this bacteria to constantly changing environments allows it to acquire a great number of antimicrobial resistance mechanisms. Thus, the prevalence of antimicrobial resistance in these commensal bacteria (or others, such as enterococci) can be a good indicator for the selective pressure caused by the use of antimicrobial agents, providing an early warning of the emergence of antimicrobial resistance in pathogens. As many as 90% of E. coli strains are commensals inhabiting the intestinal tracts of humans and warm-blooded animals. As a commensal, it lives in a mutually beneficial association with its hosts and rarely causes diseases. However, E. coli also remains as one of the most frequent causes of several common bacterial infections in humans and animals. In humans, it is the prominent cause of enteritis, community- and hospital-acquired urinary tract infection (UTI), septicemia, postsurgical peritonitis, and other clinical infections, such as neonatal meningitis, while, in farm animals, it is more prominently associated with diarrhea. On a global scale, E. coli can be considered the most important human pathogen, causing severe infection along with other major bacterial foodborne agents, such as Salmonella spp. and Campylobacter. Thus, the importance of resistance in E. coli, typically considered a benign commensal, should not be underestimated.

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Section: Antimicrobial Resistance Trends In E Colimentioning

confidence: 99%

Escherichia coli as Commensal and Pathogenic Bacteria among Food-Producing Animals: Health Implications of Extended Spectrum β-Lactamase (ESBL) Production

Ramos

Silva

Dapkevicius

et al. 2020

Animals

153

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“…Despite genetic similarities, other Enterobacteriaceae species like Escherichia coli , are not good predictors of AR in Salmonella , even from the same sample ( Nyirbahizi et al, 2020 ). Additionally, distribution of plasmid types and accessory genes these plasmids carry can differ in Salmonella compared to other Enterobacteriaceae, although estimates of plasmid frequencies can be biased by the tendency to sequence clinically relevant strains from humans and animals ( Williams et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Transferable Plasmids of Salmonella enterica Associated With Antibiotic Resistance Genes

2020

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Salmonella enterica is a common foodborne illness in the United States and globally. An increasing number of Salmonella infections are resistant to antibiotics, and many of the genes responsible for those resistances are carried by plasmids. Plasmids are important mediators of horizontal gene exchange, which could potentially increase the spread of antibiotic resistance (AR) genes. Twenty-eight different incompatibility groups of plasmids have been described in Enterobacteriaceae. Incompatibility groups differ in their accessory gene content, replication mechanisms, and their associations with Salmonella serotypes and animal sources. Plasmids also differ in their ability to conjugate or be mobilized, essential genes, and conditions required for transfer. It is important to understand the differences in gene content and transfer mechanisms to accurately determine the impact of plasmids on the dissemination and persistence of antibiotic resistance genes. This review will cover the most common plasmid incompatibility groups present in S. enterica with a focus on the transfer mechanisms and associated antibiotic resistance genes.

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“…The level of AMR in E. coli is a good indicator of AMR in bacterial pathogens of dogs and other species [20,21] because of its ubiquitous nature and its ability to act as a reservoir of AMR genes that can transferred to other pathogens through horizontal gene transfer [22]. Additionally, AMR in E. coli is suggested to be a good sentinel of the effects of selective pressure from AMU [23].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial susceptibility and risk factors for resistance amongEscherichia coliisolated from canine specimens submitted to a diagnostic laboratory in Indiana, 2010-2019

Ekakoro

Hendrix

Guptill

et al. 2022

Preprint

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Escherichia coli (E. coli) is the most common Gram-negative pathogen isolated in human infections. Antimicrobial resistant (AMR) E. coli originating from dogs may directly or indirectly cause disease in humans. The objective of this study was to calculate the proportion of antimicrobial susceptible E. coli isolated from canine specimens submitted to the Indiana Animal Disease Diagnostic Laboratory and to identify temporal patterns of susceptibility among these isolates. Susceptibility data of 2,738 E. coli isolates from dogs from 2010 through 2019 were used in this study. Proportions of isolates susceptible to the various antimicrobials were calculated using SAS statistical software and the Cochran-Armitage trend test was used to investigate the temporal trends in susceptibility. A multivariable binary logistic regression model was built to investigate the association between host factors and AMR. Overall, 553/2,738 (20.2%) of the isolates were susceptible to 17 of the 27 antimicrobials examined. Of the 2,638 isolates examined for amikacin susceptibility, 2,706 (97.5%) were susceptible, 2,657/2,673 (99.4%) isolates were susceptible to imipenem, and 2,099/2,670 (78.6%) were susceptible to marbofloxacin. A significant decreasing trend in susceptibility was observed for amoxicillin-clavulanic acid (P<0.0001), ampicillin (P<0.0001), Cefazolin (P<0.0001), ceftazidime (P=0.0067), chloramphenicol (P<0.0001), and orbifloxacin (P=0.008). The overall percentage of AMR isolates (isolates not susceptible to at least one antimicrobial) was 61.7% (1,690/2,738) and 29.3 % (801/2,738) of isolates were multidrug resistant. Multivariable regression analyses showed significant associations between AMR and age (P=0.0091), breed (P=0.0008), and sample isolation site/source (P<0.0001). The decreasing trend in the proportion of isolates susceptible to several beta-lactam antimicrobials suggests that resistance of Escherichia coli in dogs to these antimicrobials could be increasing in Indiana. The decreasing trend in susceptibility to these drugs could be due to selection pressure from antimicrobial use.

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Evaluation of Escherichia coli as an indicator for antimicrobial resistance in Salmonella recovered from the same food or animal ceca samples

Cited by 32 publications

References 24 publications

Escherichia coli as Commensal and Pathogenic Bacteria among Food-Producing Animals: Health Implications of Extended Spectrum β-Lactamase (ESBL) Production

Escherichia coli as Commensal and Pathogenic Bacteria among Food-Producing Animals: Health Implications of Extended Spectrum β-Lactamase (ESBL) Production

Transferable Plasmids of Salmonella enterica Associated With Antibiotic Resistance Genes

Antimicrobial susceptibility and risk factors for resistance amongEscherichia coliisolated from canine specimens submitted to a diagnostic laboratory in Indiana, 2010-2019

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