Evaluation of ethephon induced oxidative stress to gonadal disorder and its amelioration by ethanolic extract of shoot of Bambusa balcooa Roxb. in Albino rat

Dutta, Uma

doi:10.1016/j.toxlet.2015.08.776

Cited by 9 publications

(8 citation statements)

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“…This remarkable reduction of sexual hormones might be explained by severe damages, which Ethephon exerted on Leydig and Sertoli cells through generating free radicals. This finding was in line with that of Dutta who demonstrated that treatment of mice with Ethephon induces reproductive toxicity and oxidative stress. Also, Joshi et al demonstrated that treatment of rats with organophosphorus compound, chlorpyrifos, induces testicular toxicity.…”

Section: Discussionsupporting

confidence: 92%

“…Ethephon is a plant growth regulator used in a variety of crops and causes many problems to farmers including male infertility through inducing testicular oxidative stress . Reactive oxygen species (ROS) are generated in male germ cells as they needed it at low physiologic levels to regulate sperm capacitation, acrosome reaction, and sperm‐oocyte fusion .…”

Section: Discussionmentioning

confidence: 99%

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Ameliorative effects of Saussurea lappa root aqueous extract against Ethephon‐induced reproductive toxicity in male rats

Eldaim

Tousson

Sayed

et al. 2018

Environmental Toxicology

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This study was designed to evaluate protective effect of Saussurea lappa root aqueous extract against Ethephon (2-chloroethylphosphonic acid)-induced reproductive toxicity in rats. Control group received distilled water. Second group was given S. lappa extract at a dose 50 mg/kg bw.Third group was given Ethephon at a dose 200 mg/kg bw. Fourth, fifth, and sixth groups were given S. lappa extract before, with or after Ethephon administration, respectively. Ethephon intoxication significantly decreased serum levels of follicle stimulating hormone, luteinizing hormone, testosterone, and prolactin. Also, it significantly decreased sperms count, vitality, morphology index, total motility, progressive motility, and proliferating cell nuclear antigen protein expressions in spermatogonia. However, it significantly increased sperms abnormalities, testicular tissue and DNA damages, P53 protein expressions, noprogressive motility, and immotile sperms. In contrast, S. lappa extract ameliorated these alterations. These results indicated that S. lappa had potential preventive and curative effects against Ethephon-induced reproductive toxicity in rats.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Ameliorative effects of Saussurea lappa root aqueous extract against Ethephon‐induced reproductive toxicity in male rats

Eldaim

Tousson

Sayed

et al. 2018

Environmental Toxicology

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“…Plant growth promoter ethephon has been reported to induce damage to the kidneys and liver . It has been reported to induce reproductive toxicity in rats . Ethephon has been reported to cause toxic, mutagenic, and teratogenic effects; found to reduce DNA and RNA concentrations; and also found to inhibit cholinesterase enzyme activity .…”

Section: Introductionmentioning

confidence: 99%

“…5,6 It has been reported to induce reproductive toxicity in rats. 7,8 Ethephon has been reported to cause toxic, mutagenic, and teratogenic effects; found to reduce DNA and RNA concentrations; and also found to inhibit cholinesterase enzyme activity. 9-11 Furthermore, it can induce oxidative stress that triggered toxic effects that affect the survival of insects.…”

mentioning

confidence: 99%

Modulatory effects of Saussurea lappa root aqueous extract against ethephon‐induced kidney toxicity in male rats

Tousson

El-Atrsh

Mansour

et al. 2019

Environmental Toxicology

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Ethephon (2‐chloroethyl phosphonic acid) is a plant growth promoter used to control the plant growth process by liberating ethylene and stimulating the production of endogenous ethylene. Medicinal plants are sources of novel drug discovery targets. Costus (Saussurea lappa) has been used as traditional Chinese medicine. The current study was conducted to examine the possible modifying effects of costus (S. lappa) root aqueous extract against kidney toxicity induced by ethephon in male rats. A total of 50 adult male rats were divided into five groups (first, control; second, costus; third, ethephon; fourth, posttreated ethephon with costus; fifth, ethephon self‐healing). There is a significant increase in the serum levels of urea, creatinine, potassium ions, chloride ions, kidney injury, DNA damage, and proliferating cell nuclear antigen expressions in treated rats with ethephon when compared to the control group. In contrast, the treated rats with ethephon revealed a significant decrease in the levels of sodium ions and an insignificant decrease in the calcium ions. Saussurea lappa extract modified these alterations when compared to the control group. As a result, costus root extract significantly reduced rat kidney toxicity after ethephon administration. We recommend costus to be included in diet for its valuable effects, and also producers and consumers should become more aware about the toxic effects of ethephon.

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“…39 Além de glifosato, há outras moléculas, como paraquat, fluroxypyr, 2,4-D, atrazina e diuron, herbicida pré-emergente, amplamente, aplicado em lavouras canavieiras, indutoras de estresses oxidativos em espécies vegetais, estimulando-as à produção de enzimas antioxidantes. 44 35,47,48,49,50 Portanto, presumiu-se que este foi o motivo, pelo qual, o tratamento dos cultivares com etefon, isoladamente, resultou em maiores atividades específicas de POD.…”

Section: Catalase (Cat)unclassified

Technological Parameters and Evaluation of Antioxidant Enzymes from Sugarcane (Saccharum spp.) when Applied Chemical Ripeners

Moreira¹,

Viana²,

Manarelli³

et al. 2018

Rev. Virtual Quim.

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Rev. Virtual Quim. |Vol 10| |No. 5| |1225-1247| 1225 Artigo Parâmetros Tecnológicos e Avaliação de Enzimas Antioxidantes da Cana-de-açúcar (Saccharum spp.) quando Aplicados Maturadores Químicos Moreira, B. R. A.;* Viana, R. S.; Manarelli, F.; Viana, C. R. A.; Nakamune, A. C. M. S.Abstract: The aim of this study was to evaluate juice technological traits and antioxidant enzymes specific activities from sugarcane cultivars following chemical ripeners spraying. The field experiment had a randomized block design (with six replicates) in factorial arrangment (9x2): active ingredients (control 0.00 L ha -1 , ethephon 0.67 L ha -1 , glyphosate 0.35 L ha -1 , MTD 1.00 L ha -1 , trinexapacethyl 0.80 L ha -1 , sulfumeturon-methyl 0.02 kg ha -1 , ethephon 0.34 L ha -1 plus glyphosate 0.15 L ha -1 , MTD 1.00 L ha -1 plus glyphosate 0.15 L ha -1 , and sulfumeturon-methyl 0,02 kg ha -1 plus glyphosate 0.15 L ha -1 ), and sugarcane cultivars (RB86-5156 and RB86-5453), respectively. Subsequent to crop harvest (carried out 60-days after chemical ripeners spraying) stalks and leaf samples were assessed to °Brix, Pol, purity, theoretical sugars recoverable (TSR), fibers, superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), and peroxidase (POD) specific activities. There was null hypothesis rejection at interactive level between causes of variation for CAT and POD; while SOD, PAX, and all juice traits were affected only at simple effects level. It was concluded that chemical ripeners management enhanced juice quality and antioxidant enzymatic system reactivity of sugarcane crop. ResumoO objetivo desta pesquisa foi avaliar parâmetros tecnológicos de caldo e atividades específicas de enzimas antioxidantes de cultivares de cana-de-açúcar tratados com maturadores químicos. Aplicou-se o delineamento de blocos casualizados, com seis repetições, em esquema fatorial 9x2: ingredientes ativos (controle 0,00 L ha -1 , etefon 0,67 L ha -1 , glifosato 0,35 L ha -1 , MTD 1,00 L ha -1 , etil-trinexapac 0,80 L ha -1 , sulfumeturon-metil 0,02 kg ha -1 , etefon 0,34 L ha -1 + glifosato 0,15 L ha -1 , MTD 1,00 L ha -1 + glifosato 0,15 L ha -1 e sulfumeturon-metil 0,02 kg ha -1 + glifosato 0,15 L ha -1 ) e cultivares (RB85-5156 e RB85-5453), correspondentemente. Posteriormente à operação de colheita, realizada sessenta dias após a aplicação de maturadores, destinaram-se colmos e folhas ao laboratório, para determinação dos parâmetros tecnológicos de caldo, °Brix, Pol, Pureza, ATR e Fibras, e análise de atividades específicas das enzimas antioxidantes, superóxido dismutase (SOD), catalase (CAT), ascorbato peroxidase (APX) e peroxidase (POD), respectivamente. Houve rejeição de hipótese de nulidade, ao nível de interação entre as causas de variação, para CAT e POD; SOD, APX e todos os atributos de caldo foram influenciados, apenas, ao nível de efeitos isolados. Portanto, concluiu-se que plantas submetidas à aplicação de maturadores químicos exibiram qualidades de caldo superiores e sistemas antioxidantes enzimáticos mais reativos a radi...

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Evaluation of ethephon induced oxidative stress to gonadal disorder and its amelioration by ethanolic extract of shoot of Bambusa balcooa Roxb. in Albino rat

Cited by 9 publications

References 0 publications

Ameliorative effects of Saussurea lappa root aqueous extract against Ethephon‐induced reproductive toxicity in male rats

Ameliorative effects of Saussurea lappa root aqueous extract against Ethephon‐induced reproductive toxicity in male rats

Modulatory effects of Saussurea lappa root aqueous extract against ethephon‐induced kidney toxicity in male rats

Technological Parameters and Evaluation of Antioxidant Enzymes from Sugarcane (Saccharum spp.) when Applied Chemical Ripeners

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