Aim. to assess long-term results of primary angiosurgical prevention of ischemic stroke (is) in patients with multifocal atherosclerosis. Material and methods. this paper analyzes the long-term results of primary angiosurgical prevention of ischemic stroke in 105 patients with multifocal atherosclerosis to create an algorithm of survey and follow-up of these patients. Conclusion. Carotid endarterectomy (CeA) is highly effective method for primary prevention of is if it is performed with strict indications and in certain patients. important follow-up clinical criteria are severity of non-specific complaints of headache, dizziness, auscultatory systolic murmur in the projection of carotid arteries (CA), carotid stenosis severity and the types of atherosclerotic plaques according to duplex scanning, as well as quantitative measures of total cholesterol (tC), very low density lipoproteins (VLdL), atherogenic index.