2014
DOI: 10.5812/ircmj.12437
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Evaluation of FcγRIIIB-NA1/NA2 Polymorphism in Visceral Leishmaniasis

Abstract: Background:Several lines of evidence demonstrating that innate and adaptive immunity play important roles in the defense against visceral leishmaniasis (VL). A polymorphism within the FcγRIIIB gene can lead to the expression of three variants of NA1, NA2, and the combined one (NA1/NA2) which alters affinity of IgG to its receptor.Objectives:The main aim of this study was to evaluate the FcγRIIIB-NA1/NA2 polymorphism in the FcγRIIIB gene of VL patients in comparison to healthy controls.Patients and Methods:In t… Show more

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Cited by 3 publications
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“…VL is an infection of the reticular-endothelial system. [ 1 2 3 4 ] The parasite migrates to the internal organs such as liver, spleen, and bone marrow, and if left untreated, will almost always result in the death of the host. It is found throughout parts of the old and new worlds and can infect humans as well as domes-tic and wild animals.…”
mentioning
confidence: 99%
“…VL is an infection of the reticular-endothelial system. [ 1 2 3 4 ] The parasite migrates to the internal organs such as liver, spleen, and bone marrow, and if left untreated, will almost always result in the death of the host. It is found throughout parts of the old and new worlds and can infect humans as well as domes-tic and wild animals.…”
mentioning
confidence: 99%