Evaluation of Flavonoid Derivative and Doxorubicin Effects in Lung Cancer Cells (A549) Using Differential Pulse Voltammetry Method

Amjadi, Mohammad; Khoshraj, Jalal Mohammadi; Majidi, Mir Reza; Baradaran, Behzad; Guárdia, Miguel de la

doi:10.15171/apb.2018.072

Cited by 12 publications

(5 citation statements)

References 32 publications

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“…Flavonoid modified drugs (FMD) have much a better effect on lung cancer cell line A549 and L929 [ 53 ]. Allium flavum and Allium carinatum are wild, edible onions rich in flavonoids, rutin, quercetin 3- O -glucoside, and kaempferol-3- O -glucoside.…”

Section: Effects Of Flavonoids On Human Healthmentioning

confidence: 99%

Important Flavonoids and Their Role as a Therapeutic Agent

et al. 2020

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Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of medicinal benefits, including anticancer, antioxidant, anti-inflammatory, and antiviral properties. They also have neuroprotective and cardio-protective effects. These biological activities depend upon the type of flavonoid, its (possible) mode of action, and its bioavailability. These cost-effective medicinal components have significant biological activities, and their effectiveness has been proved for a variety of diseases. The most recent work is focused on their isolation, synthesis of their analogs, and their effects on human health using a variety of techniques and animal models. Thousands of flavonoids have been successfully isolated, and this number increases steadily. We have therefore made an effort to summarize the isolated flavonoids with useful activities in order to gain a better understanding of their effects on human health.

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Section: Effects Of Flavonoids On Human Healthmentioning

confidence: 99%

Important Flavonoids and Their Role as a Therapeutic Agent

et al. 2020

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“…OroxylinA-7-O-β-D-glucuronide is a flavonoid derivative and has a principal effect as radical scavenging properties with potent anticancer aspects. Flavonoid modified drug (FMD) is the recent class of anticancer drugs with a better effect on lung cancer [9]. Very little and sporadic information is available on the biodistribution of Oroxylum uptake and biodistribution in the cancer tissue.…”

Section: Introductionmentioning

confidence: 99%

Insight into OroxylinA-7-O-β-d-Glucuronide-Enriched Oroxylum indicum Bark Extract in Oral Cancer HSC-3 Cell Apoptotic Mechanism: Role of Mitochondrial Microenvironment

et al. 2021

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Oroxylum indicum, of the Bignoniaceae family, has various ethnomedical uses such as an astringent, anti-inflammatory, anti-bronchitis, anti-helminthic and anti-microbial, including anticancer properties. The druggability of OI stem bark extract was determined by its molecular docking interactions with PARP and Caspase-3, two proteins involved in cell survival and death. Note that 50 µg/mL of Oroxylum indicum extract (OIE) showed a significant (p < 0.05%) toxicity to HSC-3 cells. MTT aided cell viability and proliferation assay demonstrated that 50 µg/mL of OIE displayed significant (p < 0.5%) reduction in cell number at 4 h of incubation time. Cell elongation and spindle formation was noticed when HSC-3 cells were treated with 50 µg/mL of OIE. OIE initiated DNA breakage and apoptosis in HSC-3 cells, as evident from DNA ladder assay and calcein/EB staining. Apoptosis potential of OIE is confirmed by flow cytometer and triple-staining (live cell/apoptosis/necrosis) assay. Caspase-3/7 fluorescence quenching (LANCE) assay demonstrated that 50 µg/mL of OIE significantly enhanced the RFU of caspases-3/7, indicating that the apoptosis potential of OIE is probably through the activation of caspases. Immuno-cytochemistry of HSC-3 cells treated with 50 µg/mL of OIE showed a significant reduction in mitochondrial bodies as well as a reduction in RFU in 60 min of incubation time. Immunoblotting studies clearly showed that treatment of HSC-3 cells with OI extract caused caspase-3 activation and PARP deactivation, resulting in apoptotic cell death. Overall, our data indicate that OIE is an effective apoptotic agent for human squamous carcinoma cells and it could be a future cancer chemotherapeutic target.

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“…Obviously, the weakness of the immune system due to heavy therapies in patients coping with cancer plays an important role in patients' predisposition in catching infectious diseases. For instance, Cisplatin is a common treatment in lung cancer, and it has confirmed positive effects on apoptosis stimulation, nephrotoxicity, myelotoxicity, and immunosuppression and it is clear that apoptosis and immunosuppression processes can modulate the immune system's capability in confronting infectious diseases like TB (29)(30)(31)(32)(33).…”

Section: Discussionmentioning

confidence: 99%

Association of Lung Cancer and Tuberculosis: A Cross Sectional Study from Northwest of Iran

et al. 2019

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Background: Tuberculosis (TB) is a life-threatening disease, which still remains a major public health concern in Iran, as the country is an endemic region for TB. On the other hand, carcinoma of the lung is the most common and lethal cancer. As the lung cancer involves respiratory system, it has many common connections with TB, too, and it is likely that immunosuppressant drugs, like the ones used in cancer treatments, increase the risk of TB development. Objectives: To assess the possible association of TB and lung cancer, the current study evaluates the incidence of TB among patients with lung cancer. Methods: In the present cross-sectional study, patients with diagnosis of lung cancer were selected from the referral centers between 2011 and 2016. The TB among the patients was diagnosed, using radiographic pulmonary infiltration, M. tuberculosis culturing, and sputum smear. The diagnostic tests were done twice to certitude the results. Results: From 845 cases entering the study, 9 patients (1.1%) were diagnosed with TB and the smear test was positive in 5 patients. The cases aged between 40 and 67 years old, with the mean age of 53.92 ± 8.02. Women had a significantly more average age than men and adenocarcinoma was the most common type of lung cancer with a rate of 57.63%. Conclusions: According to results of current study, there was a relationship between lung cancer and TB, while the incidence of TB in patients with lung cancer was more than the normal average rate of TB incidence in the region.

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Evaluation of Flavonoid Derivative and Doxorubicin Effects in Lung Cancer Cells (A549) Using Differential Pulse Voltammetry Method

Cited by 12 publications

References 32 publications

Important Flavonoids and Their Role as a Therapeutic Agent

Important Flavonoids and Their Role as a Therapeutic Agent

Insight into OroxylinA-7-O-β-d-Glucuronide-Enriched Oroxylum indicum Bark Extract in Oral Cancer HSC-3 Cell Apoptotic Mechanism: Role of Mitochondrial Microenvironment

Association of Lung Cancer and Tuberculosis: A Cross Sectional Study from Northwest of Iran

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