Important Flavonoids and Their Role as a Therapeutic Agent

Abstract

Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of medicinal benefits, including anticancer, antioxidant, anti-inflammatory, and antiviral properties. They also have neuroprotective and cardio-protective effects. These biological activities depend upon the type of flavonoid, its (possible) mode of action, and its bioavailability. These cost-effective medicinal components have significant biological activities, and their effectiveness has been proved for a variety of diseases. The most recent work is focused on their isolation, synthesis of their analogs, and their effects on human health using a variety of techniques and animal models. Thousands of flavonoids have been successfully isolated, and this number increases steadily. We have therefore made an effort to summarize the isolated flavonoids with useful activities in order to gain a better understanding of their effects on human health.

Does Flavonoid Consumption Improve Exercise Performance? Is It Related to Changes in the Immune System and Inflammatory Biomarkers? A Systematic Review of Clinical Studies since 2005

“…Related to these or other properties, flavonoid intakes have been associated with numerous health-promoting physiological benefits for cardiovascular disease, cancer, neurological disorders, aging, obesity, etc. [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. For this reason, a wide range of human intervention studies has been developed, and the results offer promising applications in the prevention of several disorders.…”

Tea as a Source of Biologically Active Compounds in the Human Diet

“…The best-known and most widely described is the antioxidant activity of phenolic compounds and their stabilising effect on the capillary vessel walls [11,12]. Epidemiological studies have demonstrated a correlation between the consumption of phenolic compounds and a reduced incidence of certain types of neoplasms and other chronic diseases, e.g., cardiovascular, neurodegenerative diseases, and type II diabetes [6,9,[13][14][15][16][17][18].…”

“…The biological effects of phenolic compounds also include the antiosteoporotic, antiatherosclerotic, antiallergic, anti-obesity, antifibrotic, hypolipidemic, hypocholesterolemic, antidiabetic, antiviral, antimutagenic, antimicrobial, and even antidepressant effects [ 19 , 20 , 21 , 22 , 23 ]. Ullah et al [ 12 ] believe that due to the wide range of health-promoting effects of polyphenols, their conjugates in combination with important drugs may enhance the potency of these compounds and possibly even extend their therapeutic effects. The studies of Diniz et al [ 24 ] are particularly interesting in this aspect because these authors showed that quercetin (which is a flavonoid, the main group of polyphenols) can be used as a tool in the treatment of renal dysfunction, which may prevent the clinical deterioration of patients infected with COVID-19 and, consequently, improve their health and reduce the mortality caused by this disease.…”

Review of The Effectiveness of Plant Media Extracts in Barium Hexaferrite Magnets (BaFe12O19)

“…Piper betle Linn is a medicinal plant that has the property of absorbing electromagnetic waves due to its high avonoid content as an adsorbent compared to other plants (Purba, 2019). Flavonoids are natural phenolic compounds that can adsorb free radicals by donating hydrogen atoms from hydroxyl groups (Ullah et al, 2020). Flavonoid compounds can absorb electromagnetic radiation through hydrophobic interactions, ion exchange, and electrostatic due to electrons undergoing electronic transitions.…”