Evaluation of fluorescent dyes forin vivo pH measurement

A fibre-optical sensor has been developed based on the fluorescent indicator 8-hydroxyl-1,3,6-pyrene trisulphonic acid trisodium salt (HOPSA) for monitoring physiological pH values. Dowex-1 strongly basic anion exchange resin is used as the medium to immobilise the indicator on the end of an optical fibre. Polyurethane is coated on the sensor as the permeable membrane for H+. The properties of HOPSA in solution, as well as when immobilised on the sensor, are studied and found to have the potential for monitoring physiological pH values.

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Fibre-optical sensor based on fluorescent indicator for monitoring physiological pH values

Zhang

Tanaka

Wickramasinghe

et al. 1995

Med. Biol. Eng. Comput.

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Intravascular carbon dioxide monitoring using micro-flow colorimetry

Cooney

Towe

1997

Biosensors and Bioelectronics

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Pharmaceutical and biomedical applications of fiber optic biosensors based on infra red technology

Kerslake

Wilson

1996

Advanced Drug Delivery Reviews

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Evaluation of fluorescent dyes forin vivo pH measurement

Cited by 3 publications

References 6 publications

Fibre-optical sensor based on fluorescent indicator for monitoring physiological pH values

Fibre-optical sensor based on fluorescent indicator for monitoring physiological pH values

Intravascular carbon dioxide monitoring using micro-flow colorimetry

Pharmaceutical and biomedical applications of fiber optic biosensors based on infra red technology

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