Pharmaceutical and biomedical applications of fiber optic biosensors based on infra red technology

Kerslake, E.D.S.; Wilson, Calum

doi:10.1016/s0169-409x(96)00408-5

Cited by 15 publications

(30 citation statements)

References 25 publications

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“…It can also be used to suppress scattering in measurements, as well as remove baseline drift, thus acting as a good noise filter for the spectra [20,22,23]. The spectra were converted to their corresponding second derivatives with the same Shimadzu IRsolution 1.10Ò software program (Creon Lab Control AG, Shimadzu Corporation Pte.…”

Section: Discussionmentioning

confidence: 99%

“…Other advantages, besides increased resolution and signal-to-noise ratio, are its decreased size and cost [20]. Both qualitative and quantitative analyses can be performed using the mid-infrared (MIR) spectrum as the spectral data provides information about the chemical species within a particular sample based on their vibrational transitions [18].…”

Section: Introductionmentioning

confidence: 99%

“…Both qualitative and quantitative analyses can be performed using the mid-infrared (MIR) spectrum as the spectral data provides information about the chemical species within a particular sample based on their vibrational transitions [18]. The principle in which IR spectroscopy is based upon [20] is when low energy transitions occur in molecules of the sample material, they absorb the IR radiation, hence resulting in absorbance bands which can be used for quantitative analysis or identification of the major structural features or basic functional groups of the molecules. No two chemical structures will have identical IR spectra since each type of bond in different compounds will have different vibrational frequencies [21].…”

Section: Introductionmentioning

confidence: 99%

“…No two chemical structures will have identical IR spectra since each type of bond in different compounds will have different vibrational frequencies [21]. Hence the IR spectra, which is a usually plot of percent transmittance or absorbance vs. frequency expressed in wave-numbers (1/k or cm )1 ) [20], can be used as a ''fingerprint'' for compound identification [21].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Authentication of traditional Chinese medicine using infrared spectroscopy: distinguishing between ginseng and its morphological fakes

2006

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The quality of pharmaceutical products such as ginseng is important for ensuring consumer safety and efficacy. Ginseng is an expensive herb, and adulteration with other cheaper products may occur. Quality assurance of ginseng is needed since many of its commercial products now come in various formulations such as capsules, powder, softgels and tea. Thus traditional means of authentication via smell, taste or physical appearance are hardly reliable. Herbs like ginseng tend to exhibit characteristic infrared fingerprints due to their different chemical constituents. Here we report for the first time a rapid means of distinguishing American and Asian ginsengs from two morphological fakes--sawdust and Platycodon grandiflorum, via pattern differences and principal component analysis of their infrared spectra. Our results show that ginseng can be distinguished from both sawdust and Platycodon grandiflorum, hence there is a potential of using infrared spectroscopy as a novel analytical technique in the authentication of ginseng.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Authentication of traditional Chinese medicine using infrared spectroscopy: distinguishing between ginseng and its morphological fakes

2006

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“…medical, pharmaceutical, environmental, defense, bioprocessing, or food technology. Several reviews and books published in recent years [7,8,9,10,11,12,13,14] summarize the main achievements of biosensor research in these areas. These devices can, because of their sensitivity, selectivity, versatility, ruggedness, and capability of simultaneous multianalyte monitoring, be regarded as an interesting alternative to conventional techniques for these applications.…”

Section: Introductionmentioning

confidence: 99%

Fiber-optic biosensors – an overview

2002

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This article reviews progress and developments during the past five years in the field of optical fiber biosensors. Because of the expense and time constraints associated with modern laboratory analysis, there is a growing need for real-time, low-cost technology that can be used industrially, environmentally, and clinically, and to monitor food processing. Miniaturization, integrated systems, and multianalyte determination have become key aspects of sensor development and efforts in this direction will also be discussed, with some pointers to likely directions of future research in the area. The review will provide information about the analytical characteristics and applications of fiber-optic biosensors classified depending on the biorecognition element employed - enzymes, whole cells, antibodies, nucleic acids, and biomimetic polymers.

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Characterization of covalent immobilization on the surface of optical fibers by scanning electron microscopy and energy dispersive X‐ray spectrometry

Wang

Pang

Zhang

et al. 2009

Surface & Interface Analysis

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Chemical modifications on the surface of optical fibers have played an important role in the immobilization of biological recognition molecules. In this article, the specific goal was to characterize the covalent bond on the surface of optical fiber by scanning electron microscopy and energy dispersive X-ray spectrometry (EDS) and chemical analysis after silanization. Optical fibers pretreated with hydrofluoric acid and piranha solution were silanized in the 3-aminopropyltriethoxysilane solution, then microscopic components of silanized optical fibers were determined to validate the silanization. Results showed that carbon atom was measured with EDS, and the ratio of silicon and oxygen atom was 1 : 3.6 on its surface by calculation. Fluorescence experiments on the short silanized optical fiber segments indicated that the intensity of fluorescence was relatively weak and reached equilibrium after 3 h. Both methods, EDS and fluorescence test, were effective to characterize the covalent bond of different silanes and biological recognition molecules on the optical fibers for biosensor applications.

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Pharmaceutical and biomedical applications of fiber optic biosensors based on infra red technology

Cited by 15 publications

References 25 publications

Authentication of traditional Chinese medicine using infrared spectroscopy: distinguishing between ginseng and its morphological fakes

Authentication of traditional Chinese medicine using infrared spectroscopy: distinguishing between ginseng and its morphological fakes

Fiber-optic biosensors – an overview

Characterization of covalent immobilization on the surface of optical fibers by scanning electron microscopy and energy dispersive X‐ray spectrometry

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