Evaluation of fractions and 5,7-dihydroxy-4',6-dimethoxy-flavone fromClerodendrum phlomidis Linn. F. against Helicoverpa armigera Hub.

Duraipandiyan, Veeramuthu; Muthu, Chelliah; Baskar, Kathirvelu; Al-Dhabi, Naïf Abdullah; Ignacimuthu, S.

doi:10.1590/s1516-8913201400128

Cited by 6 publications

(5 citation statements)

References 45 publications

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“…Additionally, further COSY and HMBC correlations identified the flavonoid structure as pectolinaringenin (5,7-dihydroxy- 4′,6-dimethoxy-flavone) (1) (Fig. 1 ), by comparing the spectroscopic information with literature data [ 55 ].…”

Section: Resultsmentioning

confidence: 99%

“…It has shown antitumor activity in mice with S180 and H22 tumor cells [ 69 ]. The compound has also been reported to display larvicidal activity against Aedes aegyptia , Anopheles stephensi and Culex quinquefasciatus and larvicidal pulpicidal and oviposition deterrent activities against Helicoverpa armigera [ 55 , 74 , 75 ]. The compound inhibited constitutive and interleukin-6-induced STAT3 signaling and diminished the accumulation of STAT3 in the nucleus, blocking STAT3 DNA-binding activity in osteosarcoma cells [ 76 ].…”

Section: Discussionmentioning

confidence: 99%

“…The structures of isolated compounds were determined after analysing their various NMR spectra and comparison with established literature in the Dictionary of Natural Products and the Chemical Abstracts Services (Scifinder) [52][53][54][55][56] (Fig. 1).…”

Section: Structural Elucidation and Identification Of Isolated Compoundsmentioning

confidence: 99%

“…The compound has also been isolated from other plants belonging to other families, e.g. Plumeria ambigens S. F and Plumeria floribunda L. (Apocynaceae) [61], Clerodendrum phlomidis L.f. (Verbenaceae) [55], Kickxia ramosissima (Wall.) (Plantaginaceae) [62], and Lippia species (Verbenaceae) [63].…”

Section: Isolated Compoundsmentioning

confidence: 99%

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Flavonoids isolated from the South African weed Chromolaena odorata (Asteraceae) have pharmacological activity against uropathogens

Omokhua-Uyi

Abdalla

Leonard

et al. 2020

BMC Complement Med Ther

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Background: Urinary tract infections (UTIs) caused by opportunistic pathogens are among the leading health challenges globally. Most available treatment options are failing as a result of antibiotic resistance and adverse effects. Natural sources such as plants may serve as promising alternatives. Methods: Compounds were isolated from the South African weed Chromolaena odorata through column chromatography. Purified compounds were tested for antimicrobial activity using the p-iodonitrotetrazolium chloride (INT) colorimetric method, against uropathogenic Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Aspergillus fumigatus and Cryptococcus neoformans. Anti-biofilm, anti-adhesion and metabolic inhibition activities were investigated against selected strains. Safety of the compounds was determined against Vero monkey kidney, C3A human liver and colon (Caco2) cells. Results: Four compounds identified as pectolinaringenin (1), (±)-4′,5,7-trimethoxy flavanone (2), 5-hydroxy-3,7,4′trimethoxyflavone (3) and 3,5,7-trihydroxy-4′-methoxyflavone) (4) were isolated. Minimum inhibitory concentration (MIC) varied between 0.016 and 0.25 mg/mL. Compounds 2 and 3 showed promising antimicrobial activity against E. coli, S. aureus, K. pneumoniae, A. fumigatus and C. neoformans with MIC between 0.016 and 0.125 mg/mL, comparable to gentamicin, ciprofloxacin and amphotericin B used as positive controls. Compounds 2 and 3 showed good anti-biofilm and metabolic inhibition activities against E. coli and S. aureus but weak anti-adhesion activity against the organisms. Low toxicity with selectivity indexes between 1 and 12.625 were recorded with the compounds, indicating that the compounds were rather toxic to the microbial strains and not to the human and animal cells.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Structural Elucidation and Identification Of Isolated Compoundsmentioning

confidence: 99%

Section: Isolated Compoundsmentioning

confidence: 99%

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Flavonoids isolated from the South African weed Chromolaena odorata (Asteraceae) have pharmacological activity against uropathogens

Omokhua-Uyi

Abdalla

Leonard

et al. 2020

BMC Complement Med Ther

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“…In the same way, many chloroform extracts from plants have shown antifeedant activities against Lepidoptera species. For example, chloroform extracts of Atalantia monophylla (Baskar et al 2009), Caesalpinia bonduc (Baskar et al 2018), and Clerodendrum phlomidis (Duraipandiyan et al 2015;Muthu et al 2015) were antifeedant agents against Helicoverpa armigera (Lepidoptera: Noctuidae) at concentrations between 0.02 and 5%. Additionally, chloroform extract of Gloriosa superba elicited an antifeedant behavior from Spodoptera litura (Lepidoptera: Noctuidae) (Nebapure et al 2016) at 0.03% concentration.…”

Section: Discussionmentioning

confidence: 99%

Antifeedant Activities of Organic Fractions from Cestrum parqui Leaves on the Red-Haired Bark Beetle Hylurgus ligniperda

Huanquilef

Espinoza

Mutis

et al. 2020

J Soil Sci Plant Nutr

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Hylurgus ligniperda is one of the most important quarantine forest insects associated to pine (Pinus radiate D. Don) logs exported from Chile. Methyl bromide fumigation has been the prominent control method. As the use of this synthetic insecticide leads to serious environmental problems, research to find alternative treatments is urgently needed for the Chilean forestry sector. Hence, plant secondary metabolites have been considered as an alternative for its control. Therefore, the objective of this work was to assess the feeding behavior of H. ligniperda through the artificial diet supplemented with organic fractions obtained from Cestrum parqui leaves. Organic extracts were obtained using a Soxhlet extraction. Non-choice tests were developed for testing the antifeedant activity shown by the organic fractions on adults, and 5th and 6th instar larvae of H. ligniperda. All the extracts tested elicited a decrease in the weight of unsexed H. ligniperda adults, and the effects were dose-dependent. Male beetle weight gain was reduced strongly by chloroform extracts and ethyl acetate elicited a weight increase of female and from the fifth and sixth instar larvae weight. Saponin extract elicited a reduction of the weight in male and female. Finally, the weight of both instar larvae was reduced by chloroform and saponin extract. C. parqui leaf extracts show a great potential for being used for controlling H. ligniperda and thus to diminish the use of harmful synthetic pesticide.

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Efficacy of Crude Extracts of Vitex negundo Against Helicoverpa armigera (Lepidoptera: Noctuidae)

Matharu

Mehta

2023

Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci.

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Evaluation of fractions and 5,7-dihydroxy-4',6-dimethoxy-flavone fromClerodendrum phlomidis Linn. F. against Helicoverpa armigera Hub.

Abstract: Twelve fractions from chloroform extract of Clerodendrum phlomidis and 5,

Cited by 6 publications

References 45 publications

Flavonoids isolated from the South African weed Chromolaena odorata (Asteraceae) have pharmacological activity against uropathogens

Flavonoids isolated from the South African weed Chromolaena odorata (Asteraceae) have pharmacological activity against uropathogens

Antifeedant Activities of Organic Fractions from Cestrum parqui Leaves on the Red-Haired Bark Beetle Hylurgus ligniperda

Efficacy of Crude Extracts of Vitex negundo Against Helicoverpa armigera (Lepidoptera: Noctuidae)

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