Evaluation of Fumagilin-B® and other potential alternative chemotherapies against Nosema ceranae-infected honeybees (Apis mellifera) in cage trial assays

Heever, Johan P. van den; Thompson, T.S.; Otto, Simon J. G.; Curtis, Jonathan M.; Ibrahim, Ahmed A.; Pernal, Stephen F.

doi:10.1007/s13592-015-0409-3

Cited by 34 publications

(37 citation statements)

References 40 publications

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“…In some countries, the antibiotic fumagillin is still used for Nosema control. The effectiveness of fumagillin was recently re-evaluated and proven in both laboratory and fi eld conditions [153,154], but may depend on storage, treatment preparation and the quantity consumed by bees etc. [153].…”

Section: Infestation With Varroa Destructor and Mixed Virus Infectionsmentioning

confidence: 99%

“…[153]. In Serbia, like in the majority of the world, the use of fumagillin is not recommended due to its adverse effects on bees [154,155], the quality of bee products and consumer health, which result from its inadequate use [44,45,47,156,157]. Boxes marked with an asterisk show statistically signifi cant effects of the treatment on gene expression, when p-value was equal or less than 0.05 [138].…”

Section: Infestation With Varroa Destructor and Mixed Virus Infectionsmentioning

confidence: 99%

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Looking for the causes of and solutions to the issue of honey bee colony losses

et al. 2019

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Colony losses, including those induced by the colony collapse disorder, are an urgent problem of contemporary apiculture which has been capturing the attention of both apiculturists and the research community. CCD is characterized by the absence of adult dead bees in the hive in which few workers and a queen remain, the ratio between the brood quantity and the number of workers is heavily disturbed in favor of the former, and more than enough food is present. Robbing behavior and pests usually attacking the weakened colony do not occur. In the present paper, the causes of the emergence of this problem are discussed, as well as the measures of its prevention. The following factors, which lead to colony losses, are analyzed: shortage of high-quality food (pollen and honey); infestation with parasites, primarily with Varroa destructor, and mixed virus infections; bacterial infections (American and European foulbrood), fungal infections (nosemosis and ascosphaerosis) and trypanosomal infections (lotmariosis); and, finally, general management of the apiary. Certain preventive measures are proposed: (1) providing ample high-quality forage and clean water, (2) avoiding sugarisation, i.e. superfluous use of sugar syrup, (3) meeting the nutritional needs of the colony, (4) when feeding bees, taking care of the timing and the composition of diet, avoiding pure sugar syrup which in excessive quantities may induce energetic and oxidative stress, (5) when there is a shortage of natural feed – honey in the brood chamber – use sugar syrup with natural/artificial supplements to avoid protein starvation, (6) organized control of V. destructor in the colonies is obligatory due to its vector role, and (7) compliance with hygienic and sanitary measures and principles of good apiculture practice and management in apiaries. To conclude, all preventive measures are feasible in compliance with rules and regulations concerning regular spring and autumn bee health monitoring by licensed veterinarians, who can propose adequate treatments if necessary.

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Section: Infestation With Varroa Destructor and Mixed Virus Infectionsmentioning

confidence: 99%

Section: Infestation With Varroa Destructor and Mixed Virus Infectionsmentioning

confidence: 99%

Looking for the causes of and solutions to the issue of honey bee colony losses

et al. 2019

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“…Intestinal microsporidiosis due to Enterocytozoon bieneusi can cause chronic diarrhea, malabsorption, and wasting in immunocompromised patients. It has been demonstrated that fumagillin treatment leads to the clearance of microsporidia and that it could be an effective treatment for chronic E. bieneusi infection in immunocompromised patients; for example, those with AIDS [35,170]. However, some patients developed serious adverse events, such as neutropenia and thrombocytopenia, that completely disappeared after the suspension of treatment.…”

Section: Treatment Of Microsporidiosismentioning

confidence: 99%

“…These studies, among others, led Casadevall et al [34] to hypothesize that fungal virulence can be based on mechanisms developed to defend against ameboid predators. Besides, fumagillin has pharmaceutical potential for the treatment of microsporidiosis [35], as it is the only effective chemical treatment currently available for nosemiasis caused by the parasitic fungi from the Microsporidia phylum on Apis spp. [36].…”

Section: Introductionmentioning

confidence: 99%

Fumagillin, a Mycotoxin of Aspergillus fumigatus: Biosynthesis, Biological Activities, Detection, and Applications

Guruceaga

Perez-Cuesta

Abad‐Diaz‐de‐Cerio

et al. 2019

Toxins

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Fumagillin is a mycotoxin produced, above all, by the saprophytic filamentous fungus Aspergillus fumigatus. This mold is an opportunistic pathogen that can cause invasive aspergillosis, a disease that has high mortality rates linked to it. Its ability to adapt to environmental stresses through the production of secondary metabolites, including several mycotoxins (gliotoxin, fumagillin, pseurotin A, etc.) also seem to play an important role in causing these infections. Since the discovery of the A. fumigatus fumagillin in 1949, many studies have focused on this toxin and in this review we gather all the information currently available. First of all, the structural characteristics of this mycotoxin and the different methods developed for its determination are given in detail. Then, the biosynthetic gene cluster and the metabolic pathway involved in its production and regulation are explained. The activity of fumagillin on its target, the methionine aminopeptidase type 2 (MetAP2) enzyme, and the effects of blocking this enzyme in the host are also described. Finally, the applications that this toxin and its derivatives have in different fields, such as the treatment of cancer and its microsporicidal activity in the treatment of honeybee hive infections with Nosema spp., are reviewed. Therefore, this work offers a complete review of all the information currently related to the fumagillin mycotoxin secreted by A. fumigatus, important because of its role in the fungal infection process but also because it has many other applications, notably in beekeeping, the treatment of infectious diseases, and in oncology. Key Contribution:Fumagillin is a mycotoxin produced during infections caused by A. fumigatus and in the adaptation processes of this species to multiple environmental stresses. In this review; we include detailed information on the fungal mechanisms employed in the production of this mycotoxin and those present in its regulation, how it acts on its target, and how it can be detected, all of which may be useful for diagnosis or the development of new treatments. Its usefulness in different fields is also described; because of its anti-angiogenic activity it is used to attack different types of tumors; at the same time its antibiotic activity is useful against several parasites.

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“…Current treatment against nosemosis homologated in many countries (for example USA and Canada) is the antibiotics Fumagillin-B R and Fumidil-B R (Van Den Heever et al, 2015). Unfortunately, Nosema spp.…”

Section: Introductionmentioning

confidence: 99%