Evaluation of gastric carcinoembryonic antigen analysis as an aid during screening for gastric neoplasia in atrophic gastritis.

Borch, Kurt; Renvall, H.; Lundin, Christina; Wahrén, Britta

doi:10.1136/gut.28.1.26

Cited by 13 publications

(10 citation statements)

References 34 publications

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“…The first three, which are currently routinely investigated in the serum of GC patients for diagnosis and surveillance, have already been evaluated in GL of GC patients in previous studies [9,10,11,12,13,14,15]. Of interest, only one previous study dealt with the detection of CA 50 in biological fluids of GC patients other than serum, and that was not GL [16].…”

Section: Methodsmentioning

confidence: 99%

Analyzing Gastric Lavage of Gastric Cancer Patients: A Prospective Observational Study on Cytopathology and Determination of Intragastric CEA, CA 19.9, CA 72.4, and CA 50

Virgilio¹,

Giarnieri²,

Montagnini³

et al. 2016

Acta Cytologica

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Objectives: To investigate gastric lavage (GL) cytopathology and immunometric analysis as novel clinicopathologic and prognostic parameters for gastric cancer (GC). Study Design: In 38 patients with gastric adenocarcinoma, we performed a cytopathologic analysis and an immunometric assay of GL using four tumor markers (CEA, CA 19.9, CA 72.4, and CA 50). The intragastric tumor marker levels were compared with a control group consisting of 41 non-GC patients to determine a statistically significant cutoff value. Results: GL cytopathology demonstrated the presence of cancer cells in 13 (34.2%) of the 38 GC patients: such a finding correlated to the parameters pT and pN with a statistically significant validity (p < 0.0267 and p < 0.0306, respectively). Measurement of intragastric CA 19.9 and CA 50 attained a statistically significant cutoff value (p < 0.002 and p < 0.0096, respectively), which was invalidated by the low sensitivity of the ROC curve analysis. Conclusions: In contrast to determination of its tumor markers, GL cytopathology correlated well with pT and pN staging parameters. Should this and other features be corroborated by future studies, the GL cytology test could be routinely used to detect aggressive types of GC even at early stages and result in important progress in the knowledge, staging, prediction, as well as management and follow-up of this inauspicious type of cancer.

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Section: Methodsmentioning

confidence: 99%

Analyzing Gastric Lavage of Gastric Cancer Patients: A Prospective Observational Study on Cytopathology and Determination of Intragastric CEA, CA 19.9, CA 72.4, and CA 50

Virgilio¹,

Giarnieri²,

Montagnini³

et al. 2016

Acta Cytologica

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“…Through the years, clinical laboratories improved the methods of determining intragastric tumor antigens changing from qualitative to quantitative detection method, from manual add sample to automatic detection, from ELISA to chemiluminescence. Regarding the determination of GJ/GL tumor markers of GC patients, only 19 dedicated works exist in the world literature so far and this field of oncologic research covers a very limited span of time (approximately 40 years) (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). The main features pertaining to the heritage of this scientific niche are summarized in Table I.…”

Section: Abstract As Of 2017 No Serum Tumor Marker Has Shown High Lmentioning

confidence: 99%

“…Carcinoembryonic antigen (CEA) represents the endogastric tumor marker which was first investigated by the medical community and the one better analyzed to date as witnessed by the large amount of dedicated works (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(26)(27)(28)(29)(30). Historically, CEA was immunohistochemically detected both in normal and neoplastic gastric mucosa in 1972, but it was not until 1975 that Go and colleagues pioneered the determination of CEA levels in gastrointestinal secretions (12).…”

Section: Literature On Intragastric Cea (Analyzed From Gastric Juice)mentioning

confidence: 99%

Measuring Intragastric Tumor Markers in Gastric Cancer Patients: a Systematic Literature Review on Significance and Reliability

Virgilio

Proietti

D’Urso

et al. 2017

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As of 2017, no serum tumor marker has shown high levels of sensitivity or specificity for early detection, classification, staging, prediction and prognosis of patients affected by gastric cancer. In this regard, since 1975 several authors have investigated the gastric juice or gastric lavage of patients with gastric adenocarcinoma in order to determine the concentrations of intragastric tumor markers and discover the perfect antigen for this cancer. To date, however, a systematic review of the literature on intragastric tumor markers is still unreported. After a thorough search, we found important as well as unimportant findings and have come to clearly defined conclusions. We believe that describing the current state of knowledge achieved by the scientific community in this particular field of research could augment information on the complex pathobiology of gastric cancer and entail a deeper understanding of its unpredictable malignant behavior.

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“…4). Generally, the carcinoid tumours did not react to any significant degree to anti bodies against carcino-embryonic antigen (CEA) [29], As revealed by conventional electron mi croscopy, many of the tumour cells showed characteristics of the ECL cell [30], that is, varying amounts of spherical electron-dense secretory granules, 140-160 nm in diameter, some with a halo and electron-dense core and well developed rough endoplasmatic reticu lum and Golgi apparatus as well as abundant mitochondria [3, 21. 22, 31] (fig.…”

Section: No Of R E P O R T E D C a S E S {Cum Ulated)mentioning

confidence: 99%

Endocrine Cell Proliferation and Carcinoid Development: A Review of New Aspects of Hypergastrinaemic Atrophic Gastritis

Borch¹,

Renvall²,

Liedberg³

1986

Digestion

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The accumulating evidence of an association between antrum-sparing hypergastrinaemic atrophic gastritis, frequently associated with pernicious anaemia, and the occurrence of gastric carcinoid tumours is briefly reviewed. The development of argyrophil cell carcinoid tumours in the atrophic fundic mucosa seems to be related to argyrophil cell hyperplasia caused by hypergastrinaemia. Epidemiologic considerations indicate that the gastric carcinoid generally is underdiagnosed and that the incidence of this tumour is higher than previously recognized. The clinical relevance of minute gastric carcinoids, or endocrine cell ‘adenomas’, is obscure. However, larger tumours should be regarded as potentially malignant. These findings are relevant to the aspect of long-term medically induced achlorhydria leading to hypergastrinaemia.

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Evaluation of gastric carcinoembryonic antigen analysis as an aid during screening for gastric neoplasia in atrophic gastritis.

Cited by 13 publications

References 34 publications

Analyzing Gastric Lavage of Gastric Cancer Patients: A Prospective Observational Study on Cytopathology and Determination of Intragastric CEA, CA 19.9, CA 72.4, and CA 50

Analyzing Gastric Lavage of Gastric Cancer Patients: A Prospective Observational Study on Cytopathology and Determination of Intragastric CEA, CA 19.9, CA 72.4, and CA 50

Measuring Intragastric Tumor Markers in Gastric Cancer Patients: a Systematic Literature Review on Significance and Reliability

Endocrine Cell Proliferation and Carcinoid Development: A Review of New Aspects of Hypergastrinaemic Atrophic Gastritis

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