EVALUATION OF GEL STABILITY FROM Coffea arabica L. GROUNDS NANOPARTICLES

Nurman, Salfauqi; Yulia, Ruka; Irmayanti,; Noor, Erliza; Sunarti, Titi Candra

doi:10.31788/rjc.2020.1335641

Cited by 5 publications

(4 citation statements)

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“…Bioactive glass in an aqueous environment immediately begins to react in three distinct ways: leaching and exchange of cations, hydrolysis of the SiO 2 matrix, and precipitation of calcium and phosphates, leading to the formation of an appetite layer on the surface of the silica scaffold [44][45][46]. This rapid interaction with the environment is crucial for dental applications, as demonstrated by Dong et al (2011), who explored the in vitro remineralization of human dental enamel by bioactive glasses, finding significant remineralization potential and suggesting the effectiveness of bioactive glass in dental repair and maintenance [41].…”

Section: Discussionmentioning

confidence: 99%

Investigating Bioactive-Glass-Infused Gels for Enamel Remineralization: An In Vitro Study

Raszewski,

Chojnacka,

Mikulewicz

2024

JFB

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Objective: Dental hypersensitivity remains widespread, underscoring the need for materials that can effectively seal dental tubules. This study evaluated the potential of bioactive-glass-infused hydroxyethyl cellulose gels in this context. Methods: Five gels were synthesized, each containing 20% bioactive glass (specifically, 45S5, S53P4, Biomin F, and Biomin C), with an additional blank gel serving as a control. Subjected to two months of accelerated aging at 37 ± 2 °C, these gels were assessed for key properties: viscosity, water disintegration time, pH level, consistency, adhesion to glass, and element release capability. Results: Across the board, the gels facilitated the release of calcium, phosphate, and silicon ions, raising the pH from 9.00 ± 0.10 to 9.7 ± 0.0—a range conducive to remineralization. Dissolution in water occurred within 30–50 min post-application. Viscosity readings showed variability, with 45S5 reaching 6337 ± 24 mPa/s and Biomin F at 3269 ± 18 mPa/s after two months. Initial adhesion for the blank gel was measured at 0.27 ± 0.04 Pa, increasing to 0.73 ± 0.06 Pa for the others over time. Gels can release elements upon contact with water (Ca− Biomin C 104.8 ± 15.7 mg/L; Na− Biomin F 76.30 ± 11.44 mg/L; P− Biomin C 2.623 ± 0.393 mg/L; Si− 45S5-45.15 ± 6.77mg/L, F− Biomin F− 3.256 ± 0.651mg/L; Cl− Biomin C 135.5 ± 20.3 mg/L after 45 min). Conclusions: These findings highlight the gels’ capacity to kickstart the remineralization process by delivering critical ions needed for enamel layer reconstruction. Further exploration in more dynamic, real-world conditions is recommended to fully ascertain their practical utility.

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Section: Discussionmentioning

confidence: 99%

Investigating Bioactive-Glass-Infused Gels for Enamel Remineralization: An In Vitro Study

Raszewski,

Chojnacka,

Mikulewicz

2024

JFB

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“…As mentioned, the importance of spreadability lies in detecting how easily the formulation would spread over the affected area upon topical application, which achieves convenience for patients. Spreadability of the FA-SLN-hydrogel was calculated as 51.1 ± 2.4 mm, which is considered typical for topical formulations [57].…”

Section: Characterization Of Fa-sln-hydrogelmentioning

confidence: 99%

Shea Butter Potentiates the Anti-Bacterial Activity of Fusidic Acid Incorporated into Solid Lipid Nanoparticle

2022

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Fusidic acid (FA) is an efficient anti-bacterial drug proven to be efficient against a wide range of bacteria. Nevertheless, the main restriction in its formulation is the limited solubility. To avoid such an obstacle, the drug is incorporated into the lipid core of the nanolipid formulation. Consequently, the present study was an attempt to formulate nanolipid preparation, mainly, solid lipid nanoparticle (SLN) integrating FA. FA-SLN was prepared using shea butter as a lipid phase owing to its reported anti-bacterial activity. Different FA-SLNs were fabricated using the central composite design (CCD) approach. The optimized formula was selected and integrated into a hydrogel base to be efficiently used topically. FA-SLN-hydrogel was evaluated for its character, morphology, in vitro release and stability. The formula was examined for irritation reaction and finally evaluated for its anti-bacterial performance. The optimized formula showed particle size 283.83 nm and entrapment 73.057%. The formulated FA-SLN-hydrogel displayed pH 6.2, viscosity 15,610 cP, spreadability 51.1 mm and in vitro release 64.6% following 180 min. FA-SLN-hydrogel showed good stability for three months at different conditions (room temperature and refrigerator). It exhibited no irritation reaction on the treated rats. Eventually, shea butter displayed a noteworthy effect against bacterial growth that improved the effect of FA. This would indicate prospective anti-bacterial activity of FA when combined with shea butter in SLN formulation as a promising nanocarrier.

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“…The in vitro spreadability was studied by measuring the spreading surface (cm 2 ) occupied by 1 g of the CLT-MVG formulation placed between two 20 × 20 cm glass plates [30]. The mass of the upper plate was standardized at 125 g, and a 500 g mass was placed on the device.…”

Section: Determination Of Spreading Capacitymentioning

confidence: 99%

Optimization of a Mucoadhesive Vaginal Gel Containing Clotrimazole Using a D-Optimal Experimental Design and Multivariate Analysis

et al. 2023

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The aim of this study was to develop a suitable clotrimazole (CLT)-loaded mucoadhesive vaginal gel (CLT-MVG) for topical applications in vaginal candidiasis. Ten CLT-MVG formulations were prepared, consisting of mixtures of acid polyacrylic (Carbopol 940) and polyethene oxides, Sentry Polyox WSRN 1105 or 750, according to an experimental D-optimal design, and CLT was suspended at a ratio of 1%. The prepared CLT-MVG formulations were studied in vitro, and the formulation containing Carbopol 940 0.89% combined with PEO 1105 1.39% was identified with the optimal rheological and in vitro bioadhesion properties, ensuring the prolonged release of CLT, with a similarity factor greater than 50, indicating dissolution profile similarity for three batches of the optimized formulation. This optimized formulation showed a pH in the tolerance range, and an adequate ex vivo mucoadhesion time, while the FT-IR studies revealed no interactions between the excipients and CLT. The microscopic analysis identified a mean particle size of suspended CLT of 5.24 ± 0.57 μm. The in vitro antifungal activity of the optimized formulation was tested on twenty strains of Candida albicans and proved to be better compared to a marketed clotrimazole preparation, showing a greater inhibition effect (p < 0.05). The optimized formulation could be a good candidate for the local treatment of vaginal mycosis.

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EVALUATION OF GEL STABILITY FROM Coffea arabica L. GROUNDS NANOPARTICLES

Cited by 5 publications

References 0 publications

Investigating Bioactive-Glass-Infused Gels for Enamel Remineralization: An In Vitro Study

Investigating Bioactive-Glass-Infused Gels for Enamel Remineralization: An In Vitro Study

Shea Butter Potentiates the Anti-Bacterial Activity of Fusidic Acid Incorporated into Solid Lipid Nanoparticle

Optimization of a Mucoadhesive Vaginal Gel Containing Clotrimazole Using a D-Optimal Experimental Design and Multivariate Analysis

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