Evaluation of genotoxic biomarkers in extracts of marine sponges from Argentinean South Sea

Bartolotta, Susana; Scuteri, M.A.; Hick, Adriana; Palermo, Jorge Alejandro; Brasco, Maria Florencia Rodriguez; Hajdu, Eduardo; Mothes, Beatriz; Lerner, Cléa; Campos, Maurício; Carballo, Marta A.

doi:10.1016/j.jembe.2008.11.008

Cited by 8 publications

(7 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Natural triterpenes isolated from different marine sponges inhibited iNOS expression and the activation of NF- β , while polyketides showed antitumoural activity [13] . Most screenings of secondary metabolites of biomedical importance from marine sponge extracts reported an inhibitory effects that turned out to be have strongly cytotoxic effects [14,15]. …”

Section: Introductionmentioning

confidence: 99%

Chemical characterization, antioxidant and inhibitory effects of some marine sponges against carbohydrate metabolizing enzymes

et al. 2012

View full text Add to dashboard Cite

BackgroundMore than 15,000 marine products have been described up to now; Sponges are champion producers, concerning the diversity of products that have been found. Most bioactive compounds from sponges were classified into anti-inflammatory, antitumor, immuno- or neurosurpressive, antiviral, antimalarial, antibiotic, or antifouling. Evaluation of in vitro inhibitory effects of different extracts from four marine sponges versus some antioxidants indices and carbohydrate hydrolyzing enzymes concerned with diabetes mellitus was studied. The chemical characterizations for the extracts of the predominating sponges; SP1 and SP3 were discussed.MethodsAll chemicals served in the biological study were of analytical grade and purchased from Sigma, Merck and Aldrich. All kits were the products of Biosystems (Spain), Sigma Chemical Company (USA), Biodiagnostic (Egypt). Carbohydrate metabolizing enzymes; Î±-amylase, Î±-glucosidase, and Î²-galactosidase (EC3.2.1.1, EC3.2.1.20, and EC3.2.1.23, respectively) were obtained from Sigma Chemical Company (USA).ResultsFour marine sponges; Smenospongia (SP1), Callyspongia (SP2), Niphates (SP3), and Stylissa (SP4), were collected from the Red Sea at Egyptian coasts, and taxonomically characterized. The sponges' extracts exhibited diverse inhibitory effects on oxidative stress indices and carbohydrate hydrolyzing enzymes in linear relationships to some extent with concentration of inhibitors (dose dependant). The extracts of sponges (3, 1, and 2) showed, respectively, potent-reducing power. Purification and Chemical characterization of sponge 1 using NMR and mass spectroscopy, recognized the existence of di-isobutyl phthalate (1), di-n-butyl phthalate (2), linoleic acid (3), β-sitosterol (4), and cholesterol (5). Sponge 3 produced bis-[2-ethyl]-hexyl-phthylester (6) and triglyceride fatty acid ester (7).ConclusionMarine sponges are promising sources for delivering of bioactive compounds. Four marine sponges, collected from Red Sea at Egyptian coasts, were identified as Smenospongia (SP1), Callyspongia (SP2), Niphates (SP3), and Stylissa (SP4). The results demonstrated that different sponges extracts exhibited inhibitory effects on oxidative stress indices and carbohydrate hydrolyzing enzymes in linear relationships to some extent with concentration of inhibitors (dose dependant). The extracts of sponges (3, 1, and 2) showed, respectively, potent-reducing power. Chemical characterizations of sponges SP1 and SP3 were discussed. Based on this study, marine sponges are considered as talented sources for production of diverse and multiple biologically active compounds.

show abstract

Section: Introductionmentioning

confidence: 99%

Chemical characterization, antioxidant and inhibitory effects of some marine sponges against carbohydrate metabolizing enzymes

et al. 2012

View full text Add to dashboard Cite

show abstract

“…However, since compound 1 also showed some toxicity against mussels in the laboratory tests, there is the possibility that several ways of action may act simultaneously to produce the observed antifouling effect. It must be stated that the peracetylated bile acids originally isolated from S. fortis did not show significant genotoxic activity at the concentrations found in the sponge [13], and thus were not responsible for the genotoxic activity originally detected in the sponge extract [38]. However, the results of the present work clearly demonstrate the antifouling action of the acetylated bile acids, which are the main secondary metabolites in the extract of the sponge S. fortis.…”

Section: Discussionmentioning

confidence: 42%

Antifouling activity of peracetylated cholic acid, a natural bile acid derivative

et al. 2019

View full text Add to dashboard Cite

The antifouling activity of peracetylated cholic acid (1), a bile acid derivative which was isolated in a previous work as a natural product from the Patagonian sponge Siphonochalina fortis, was evaluated in laboratory and field trials. Toxicity and settlement assays were performed with the mussel Mytilus edulis platensis, while the field trials were carried out by addition of the compound to experimental soluble-matrix paints, which were then tested in the sea. The results obtained in this work show that 1 has a good antifouling activity and low toxicity, and the paints aditivated with 0,6 % Wt showed promisory performances in the field trials at the sea. These results confirm the previous hypothesis that the few acetylated and lipophilic bile acid derivatives isolated from marine invertebrates may act as natural antifoulants. Compound 1 is a natural, biodegradable product that can be easily prepared from cholic acid, which in turn can be isolated in industrial scale from cattle bile. All these facts make cholic acid a good scaffold for the preparation of derivatives, which can be natural product-like, effective and sustainable antifouling additives for marine paints and other applications.

show abstract

“…A screening of the activity of S. magellanica (Thiele, 1905) against genotoxic biomarkers (mitotic index, cell proliferation kinetics and sister chromatid exchanges) was reported, although no activity was found [ 128 ].…”

Section: Biological Activitymentioning

confidence: 99%

The Role of Spongia sp. in the Discovery of Marine Lead Compounds

et al. 2016

View full text Add to dashboard Cite

A comprehensive review on the chemistry of Spongia sp. is here presented, together with the biological activity of the isolated compounds. The compounds are grouped in sesquiterpene quinones, diterpenes, C21 and other linear furanoterpenes, sesterterpenes, sterols (including secosterols), macrolides and miscellaneous compounds. Among other reports we include studies on the intraspecific diversity of a Mediterranean species, compounds isolated from associated sponge and nudibranch and compounds isolated from S. zimocca and the red seaweed Laurentia microcladia. Under biological activity a table of the reported biological activities of the various compounds and the biological screening of extracts are described. The present review covers the literature from 1971 to 2015.

show abstract

Evaluation of genotoxic biomarkers in extracts of marine sponges from Argentinean South Sea

Cited by 8 publications

References 29 publications

Chemical characterization, antioxidant and inhibitory effects of some marine sponges against carbohydrate metabolizing enzymes

Chemical characterization, antioxidant and inhibitory effects of some marine sponges against carbohydrate metabolizing enzymes

Antifouling activity of peracetylated cholic acid, a natural bile acid derivative

The Role of Spongia sp. in the Discovery of Marine Lead Compounds

Contact Info

Product

Resources

About