Evaluation of Glypican-3 Expression in Hepatocellular Carcinoma by Using IDEAL IQ Magnetic Resonance Imaging

Chen, Rushi; Zhang, Ge; Yan, Han; Chen, Lijuan; Gao, Haiyan; Wei, Wei; Wang, Meiyun

doi:10.1016/j.acra.2020.05.015

Cited by 12 publications

(15 citation statements)

References 37 publications

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“…Chen et al. ( 19 ) reported that the R2* value yielded from iterative decomposition of water and fat with echo asymmetry and least squares estimation MRI could reliably predict GPC-3 expression in HCC prior to surgery. In addition, Gu et al.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, GPC-3 expression can be evaluated via noninvasive imaging techniques. For example, MRI specific superparamagnetic iron oxide (SPIO) anti-GPC-3 molecular probe has demonstrated the effectiveness for assessing GPC-3 expression in HCC tissues ( 14 – 16 ), and a few studies revealed the associations between GPC-3 expression with various MRI morphological features and quantitative parameters (e.g., MRI-based radiomics and iterative decomposition of water and fat with echo asymmetry and least squares estimation [IDEAL-IQ] parameters) ( 17 – 19 ). Despite promising results so far, existing evidence were not yet ready to be transformed into routine practice due to the limited application of SPIO and poor interpretability of quantitative techniques.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preoperative prediction of glypican-3 positive expression in solitary hepatocellular carcinoma on gadoxetate-disodium enhanced magnetic resonance imaging

Chen

Qin

et al. 2022

Front. Immunol.

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PurposeAs a coreceptor in Wnt and HGF signaling, glypican-3 (GPC-3) promotes the progression of tumor and is associated with a poor prognosis in hepatocellular carcinoma (HCC). GPC-3 has evolved as a target molecule in various immunotherapies, including chimeric antigen receptor T cell. However, its evaluation still relies on invasive histopathologic examination. Therefore, we aimed to develop an easy-to-use and noninvasive risk score integrating preoperative gadoxetic acid–enhanced magnetic resonance imaging (EOB-MRI) and clinical indicators to predict positive GPC-3 expression in HCC.Methods and materialsConsecutive patients with surgically-confirmed solitary HCC who underwent preoperative EOB-MRI between January 2016 and November 2021 were retrospectively included. EOB-MRI features were independently evaluated by two masked abdominal radiologists and the expression of GPC-3 was determined by two liver pathologists. On the training dataset, a predictive scoring system for GPC-3 was developed against pathology via logistical regression analysis. Model performances were characterized by computing areas under the receiver operating characteristic curve (AUCs).ResultsA total of 278 patients (training set, n=156; internal validation set, n=39; external validation set, n=83) with solitary HCC (208 [75%] with positive GPC-3 expression) were included. Serum alpha-fetoprotein >10 ng/ml (AFP, odds ratio [OR]=2.3, four points) and five EOB-MR imaging features, including tumor size >3.0cm (OR=0.5, -3 points), nonperipheral “washout” (OR=3.0, five points), infiltrative appearance (OR=9.3, 10 points), marked diffusion restriction (OR=3.3, five points), and iron sparing in solid mass (OR=0.2, -7 points) were significantly associated with positive GPC-3 expression. The optimal threshold of scoring system for predicting GPC-3 positive expression was 5.5 points, with AUC 0.726 and 0.681 on the internal and external validation sets, respectively.ConclusionBased on serum AFP and five EOB-MRI features, we developed an easy-to-use and noninvasive risk score which could accurately predict positive GPC-3 HCC, which may help identify potential responders for GPC-3-targeted immunotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preoperative prediction of glypican-3 positive expression in solitary hepatocellular carcinoma on gadoxetate-disodium enhanced magnetic resonance imaging

Chen

Qin

et al. 2022

Front. Immunol.

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“…(2) The synergistic effect of the bimetallic Pt@Pd NPs effectively enhances the sensitivity of the sensing interface. (3) The multifunctional H-rGO-Pt@Pd NPs with a large specific surface area and excellent conductivity were not only used as an effective supporting platform for GPC3 aptamer immobilization but also as a sensitive electrical signal probe. (4) The specific binding between the aptamer and its target realizes high sensitivity and low detection limit of GPC3 detection.…”

Section: Performance Of the Electrochemical Aptasensor For Determinat...mentioning

confidence: 99%

“…The increased GPC3 expression in HCC indicates the sensitivity and specificity of HCC diagnosis. 3,4 Moreover, some patients with negative alpha-fetoprotein (AFP) serum tests were positive in GPC3 serum tests with high sensitivity. 5 Therefore, GPC3 has been identified as the most promising biomarker of HCC diagnosis and immunotherapy.…”

Section: Introductionmentioning

confidence: 99%

A label-free electrochemical aptasensor based on platinum@palladium nanoparticles decorated with hemin-reduced graphene oxide as a signal amplifier for glypican-3 determination

et al. 2022

Biomater. Sci.

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“…The FF map can directly measure the fat content in the tissue (i.e., liver and bone marrow) without further calculation ( 28 , 29 ). The R2* map can also explain the inhomogeneity of the T2* effect/field, which is often used in liver iron assessment, such as liver iron overload and liver fibrosis ( 30 , 31 ). Therefore, considering the imaging principle and the output results, this sequence shows excellent potential for investigating CKD bone marrow composition changes.…”

Section: Introductionmentioning

confidence: 99%

Quantitative assessment of lumbar spine bone marrow in patients with different severity of CKD by IDEAL-IQ magnetic resonance sequence

Xiong

Liu

et al. 2022

Front. Endocrinol.

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BackgroundChronic kidney disease (CKD) has a significant negative impact on bone health. Bone marrow is an essential component of bone, mainly composed of trabecular bone and fat. The IDEAL-IQ sequence of MRI allows indirect quantification of trabecular bone mass by R2* and direct quantification of bone marrow fat content by FF map, respectively.ObjectiveOur objective was to explore the association of CKD severity with bone marrow using IDEAL-IQ and whether mineral and bone metabolism markers alter this association.MethodWe recruited 68 CKD patients in this cross-sectional research (15 with CKD stages 3-4, 26 with stage 5, and 27 with stage 5d). All patients underwent lumbar spine IDEAL-IQ, BMD, and several bone metabolism markers (iPTH, 25-(OH)-VitD, calcium and phosphorus). Multiple linear regression analysis was used to examine the association of CKD severity with MRI measurements (R2* and FF).ResultsMore severe CKD was associated with a higher R2* value [CKD 5d versus 3-4: 30.077 s-1 (95% CI: 12.937, 47.217), P for trend < 0.001], and this association was attenuated when iPTH was introduced [CKD 5d versus 3-4: 19.660 s-1 (95% CI: 0.205, 39.114), P for trend = 0.042]. Furthermore, iPTH had an association with R2* value [iPTH (pg/mL): 0.033 s-1 (95% CI: 0.001, 0.064), P = 0.041]. Besides, FF was mainly affected by age and BMI, but not CKD.ConclusionsThe bone marrow R2* value measured by IDEAL-IQ sequence is associated with CKD severity and iPTH. The R2* of IDEAL-IQ has the potential to reflect lumbar bone changes in patients with CKD.

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Evaluation of Glypican-3 Expression in Hepatocellular Carcinoma by Using IDEAL IQ Magnetic Resonance Imaging

Cited by 12 publications

References 37 publications

Preoperative prediction of glypican-3 positive expression in solitary hepatocellular carcinoma on gadoxetate-disodium enhanced magnetic resonance imaging

Preoperative prediction of glypican-3 positive expression in solitary hepatocellular carcinoma on gadoxetate-disodium enhanced magnetic resonance imaging

A label-free electrochemical aptasensor based on platinum@palladium nanoparticles decorated with hemin-reduced graphene oxide as a signal amplifier for glypican-3 determination

Quantitative assessment of lumbar spine bone marrow in patients with different severity of CKD by IDEAL-IQ magnetic resonance sequence

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