Evaluation of guggulsterone derivatives as novel kidney cell protective agents against cisplatin-induced nephrotoxicity

Guggulsterone – a potent bioactive phytosteroid: synthesis, structural modification, and its improved bioactivities

“…11. The improved activity of GS derivatives has been reported by several groups 27–29,94,95 and compound 30a is one of the hit structurally modified GS molecules showing potent anticancer activity. Therefore, those currently working on this molecule should pay more attention to the area of structural modification and to the aspects of green chemistry and late-stage diversification, especially through C–H bond activation.…”

“…Among the tested derivatives, (4-(1 H -1,2,3-triazol-4-yl)phenyl) methanol-linked compound 28b was found to be the most potent. 27 The protection effect of this compound was stronger than that of the positive control compound N -acetylcysteine. The cell viability of compound 28b at a concentration of 25 μM was found to be >90% and it was more potent than ( Z )-GS.…”

“…Hybrid compounds have captured an important position in cancer therapy, and the hybridization of triazole scaffolds with other anticancer pharmacophores may furnish valuable therapeutic interventions for cancer treatment. A study by Lee and colleagues 27 reported on triazole-guggulsterone hybrids as novel kidney cell protective agents. Based on a preliminary investigation, they focused on modifying the structure of the ( E ) isomer because it is less efficient than the ( Z ) form.…”

“…26 In addition, its chemically modified analogues have shown promise as good anticancer agents. 27–29 Due to their different biochemistry, these molecules have gained increasing importance in recent years. Based on the above considerations, there is a strong demand for GS and its analogues for further research and development, and application.…”

Procyanidin B2 3″-O-gallate Isolated from Reynoutria elliptica Prevents Glutamate-Induced HT22 Cell Death by Blocking the Accumulation of Intracellular Reactive Oxygen Species

“…As part of our ongoing projects to screen Korean natural resources possessing pharmacological capability and its responsible compounds [20,21,22,23,24,25,26,27,28,29], we assessed the neuroprotective roles of the MeOH extract of R. elliptica seeds in immortalized murine hippocampal neuronal cell line, HT22 cells, which is part of the murine hippocampal cell line. We further characterized the compounds responsible for its neuroprotective effects as procyanidins of R. elliptica .…”