Evaluation of gustatory function in <scp>HIV</scp>‐infected subjects with and without <scp>HAART</scp>

Raja, Jigna V; Rai, Puja; Khan, Mubeen; Banu, Asima; Bhuthaiah, Satish

doi:10.1111/jop.12006

Cited by 17 publications

(21 citation statements)

References 18 publications

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“…Antiretroviral drugs penetrate into the central nervous system and, therefore, may impact olfactory functions. Several studies have reported disruptive effects of HAART on olfaction and gustation (Fasunla et al 2016;Raja et al 2013). The participants of the current study, however, may be characterized with increased olfactory sensitivity.…”

Section: Limitations and Future Directionscontrasting

confidence: 45%

On the relationship between olfactory sensitivity and personality in HIV-seropositive and healthy men

et al. 2018

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The aim of this study was to further elucidate the relationship between the olfactory system and psychosocial functioning. Previous studies have shown that olfactory sensitivity is related to traits such as extraversion, agreeableness, and emotionality. In this study, the model of agency and communion as well as additional measures of social activity were used. The possible influence of HIV infection, believed to affect both chemosensory functions and social behaviors, was examined. 103 male participants were analyzed, of whom 45 were infected with HIV. Olfactory sensitivity was significantly related to the level of communion (p = .01), trait defined as interpersonal warmth, devotion to others, and morality. The effect was independent of the presence of HIV. Eagerness to engage in social activities, a construct indicating how actively one takes part in social life, was positively associated with olfactory sensitivity only in HIV+ individuals (p = .003). This result may imply that active participation in social life can buffer olfactory impairments in HIV patients.

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Section: Limitations and Future Directionscontrasting

confidence: 45%

On the relationship between olfactory sensitivity and personality in HIV-seropositive and healthy men

et al. 2018

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“…[9] Sour and bitter tastes were more affected as compared to sweet and salty tastes, which was in accordance with Raja et al . [7] The significant alteration in sour and bitter taste could be the result of adaptation to these tastes caused by continuous stimulation by HAART and also may have resulted in the higher detection threshold to it.…”

Section: Discussionmentioning

confidence: 99%

“…[56] It has also been reported that HAART therapy affects the chemosensory system in 70% of individuals and 23% of patients reported a change in the taste sensation. [7]…”

Section: Introductionmentioning

confidence: 99%

Evaluation of salivary flow rate and gustatory function in HIV-positive patients with or without highly active antiretroviral therapy

et al. 2017

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Objectives:The aim of this study is to evaluate the salivary flow rate and gustatory changes in HIV-positive patients on highly active anti-retroviral therapy (HAART) and without HAART. We also correlated CD4 count and salivary flow rate and gustatory function in both groups.Methods:Sample size for each group was thirty. After obtaining informed consent, we measured salivary flow rate using Schimer's method and gustatory function using four tastants (sweet, sour, bitter, and salty) of different concentrations. The readings were recorded at 0 month, 2nd, 4th, and 6th month interval. The data obtained was statistically analyzed.Results:The mean salivary flow rate was decreased more in Group I as compared to Group II. The mean identification score for sweet, salty, sour, and bitter was significantly higher in Group II than Group I. The mean detection threshold score for sweet, salty, sour and bitter taste was comparatively higher in Group I than Group II. The Pearson's correlation analysis showed inverse relation between age and salivary flow rate in Group II. No significant correlation was observed in CD4 count and salivary flow rate.Conclusion:Along with routine oral health appraisal in seropositive patients, evaluation of salivary flow rate, and taste abnormalities should also be considered an integral part of patient assessment.

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“…Antiretroviral medications have been associated with dysgeusia in human immunodeficiency virus patients. 13 Chemotherapeutic drugs used for treatment of cancers, especially 5-fluorouracil and its oral analogs, have also been associated with dysgeusias, with greater prevalence in the elderly. 14 Numerous other commonly prescribed drugs, described in Table 2, can contribute to dysgeusia.…”

Section: Clinical Significancementioning

confidence: 99%

The Impact of Aging and Medical Status on Dysgeusia

Syed

Hendler

Koncilja

2016

The American Journal of Medicine

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Disorders of taste and smell can cause an aversion to food in a sick patient and therefore affect his/her ability to maintain optimal nutrition. This can lead to a reduced level of strength, muscle mass, function, and quality of life. Additionally, reduced ability to differentiate between various intensities or concentrations of a tastant can result in increased intake of salt and sugar and exacerbation of chronic diseases such as heart failure and diabetes. These implications can be heightened in the elderly, who are particularly frail and are challenged by polypharmacy and multiple comorbid conditions. In this article, we will review the prevalence, etiology, and management of taste disorders. Additionally, we will review the association between taste and smell disorders and how disorders of smell can affect perception of taste.

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Evaluation of gustatory function in HIV‐infected subjects with and without HAART

Abstract: The results document significant taste losses in HIV-infected subjects, and HAART contributes considerably to such taste perversion.

Cited by 17 publications

References 18 publications

On the relationship between olfactory sensitivity and personality in HIV-seropositive and healthy men

On the relationship between olfactory sensitivity and personality in HIV-seropositive and healthy men

Evaluation of salivary flow rate and gustatory function in HIV-positive patients with or without highly active antiretroviral therapy

The Impact of Aging and Medical Status on Dysgeusia

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