Evaluation of hair loss in cats occurring after treatment with a topical flea control product

Credille, Kelly M.; Thompson, Lori A.; Young, Lisa; Meyer, Jürgen; Winkle, Joseph R.

doi:10.1111/vde.12075

Cited by 5 publications

(1 citation statement)

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“…Although that 39.6% w/v formulation of spinetoram was non-irritant, some field reports were received of focal hair loss from the application site in a small percentage of treated cats. This problem was attributed to the high viscosity of the formulation and so a formulation with a lower concentration and viscosity was developed [ 6 ]. Preliminary laboratory effectiveness studies were completed, and tolerability studies in client-owned cats demonstrated the acceptability and safety of an 11.2% formulation (unpublished observations).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness and residual speed of flea kill of a novel spot on formulation of spinetoram (Cheristin®) for cats

et al. 2017

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BackgroundA spot-on spinetoram formulation (Cheristin®) was developed to eliminate fleas from infested cats. This paper describes three spinetoram studies: two for registration (Studies 1 and 2), and one comparing residual speed of kill (SOK) with topically applied fipronil/(S)-methoprene (FSM) and imidacloprid (Study 3).MethodsCats were randomized to treatment based on flea counts from infestations placed within 2 weeks prior to treatment. In Studies 1 and 2, groups were untreated control and spinetoram; in Study 3, groups were untreated control, spinetoram, FSM and imidacloprid, all applied per label on Day 0. Cats were infested the day before treatment. In Studies 1 and 2, counts were completed 48 h post-treatment and after weekly challenges through 5 weeks. In Study 3, infestations were completed weekly through Day 28, with counts 1, 4, 8 and 12 h after treatment or post-infestation (PI). Efficacy was determined on geometric mean flea count reductions compared with controls, and in Study 3 mean flea counts in spinetoram-groups were compared with those in FSM and imidacloprid groups.ResultsIn Studies 1 and 2, spinetoram effectiveness was 100% against existing infestations, and at least 96% through Day 37. In Study 3 mean counts were not significantly different from controls in any group until 8 h post-treatment when imidacloprid counts were significantly lower than spinetoram counts, which were in turn significantly lower than FSM counts (P < 0.05). At 1 h PI spinetoram-group counts were significantly lower (P < 0.05) than counts in: controls, all days; imidacloprid, Days 7, 14, and 28; FSM, Days 14 and 28. At 4 h PI, spinetoram mean counts were significantly lower (P < 0.05) relative to: controls, all days; imidacloprid, Days 7, 14 and 21; FSM, Days 7, 14, 21 and 28 (P < 0.05). On multiple occasions, at 8 and 12 h PI, mean counts were significantly lower (P < 0.05) for spinetoram than for imidacloprid and FSM; at no point were FSM or imidacloprid significantly more effective than spinetoram against new infestations. All treatments were well tolerated.ConclusionsSpinetoram was highly effective for at least 1 month post-treatment and provided more rapid month-long residual SOK than FSM or imidacloprid.

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Section: Introductionmentioning

confidence: 99%