Evaluation of hearing loss in pediatric celiac patients

Şahin, Yasin; Durucu, Cengiz; Şahin, Derya

doi:10.1016/j.ijporl.2014.12.031

Cited by 11 publications

(5 citation statements)

References 31 publications

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“…A 2015 case–control study by Şahin et al, with large sample size (110 pediatric patients with CD and 41 age and sex-matched controls), found significantly worse bone conduction thresholds at all frequencies in patients with CD ( P < .05) and that these thresholds worsen with duration of CD ( P < .05). 11 Interestingly, the pure tone average was below 20 decibels, so the hearing loss was subclinical only at that point in time 11 but could be hypothesized to be predictive of worsening hearing loss in later life, in keeping with the findings of Leggio et al 7…”

Section: Discussionmentioning

confidence: 61%

“…10 A 2015 case-control study by Ş ahin et al, with large sample size (110 pediatric patients with CD and 41 age and sexmatched controls), found significantly worse bone conduction thresholds at all frequencies in patients with CD (P < .05) and that these thresholds worsen with duration of CD (P < .05). 11 Interestingly, the pure tone average was below 20 decibels, so the hearing loss was subclinical only at that point in time 11 but could be hypothesized to be predictive of worsening hearing loss in later life, in keeping with the findings of Leggio et al 7 The pathological mechanism behind SNHL and CD is postulated to be immune-mediated neurological damage, comprising of autoantibodies, autoreactive T cells and immune complex deposition. 12 Malnutrition may also be a component, with ischemic damage to the cochlea from iron deficiency anemia.…”

Section: Hearing Lossmentioning

confidence: 69%

“…Therefore, this association is an important learning point for the otolaryngologist. Hearing loss is well known to lead to negative effects on cognitive and social development in children 11 and therefore it is a suggestion that children with CD should have baseline hearing tests upon diagnosis, with regular hearing tests at appropriate frequencies to monitor for hearing loss with intervention as required.…”

Section: Hearing Lossmentioning

confidence: 99%

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ENT Manifestations of Celiac Disease: A Scholarly Review

Karunaratne

2020

Ear Nose Throat J

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Objectives: Celiac disease is a common multisystemic autoimmune disorder. It is now increasingly recognized that it may present with extraintestinal manifestations which contribute to the difficulty in its diagnosis. The objective of this scholarly review was to examine the extraintestinal ENT manifestations of celiac disease and its pathophysiology and management, in order to highlight that some patients with celiac disease may present initially to the otolaryngologist. Improving awareness of celiac disease among otolaryngologists may aid in the correct diagnosis and correct management plan. Methods: A literature review was conducted using the PubMed database to identify original articles related to celiac disease and ENT manifestations between the years 2000 and 2020. The search was performed using the search string: (“coeliac disease” OR “celiac disease”) AND (“ENT manifestations” OR “hearing loss” OR “epistaxis” OR “nasal septal perforation” OR “obstructive sleep apnoea” OR “vertigo” OR “tonsillitis” OR “sinusitis”). Only articles written in English were reviewed. Results: A total of 17 papers met the inclusion criteria. Extraintestinal ENT manifestations of celiac disease include sensorineural hearing loss, obstructive sleep apnea, nasal septal perforation, epistaxis, and vertigo with nystagmus. Sensorineural hearing loss, obstructive sleep apnea, nasal septal perforation, vertigo, and nystagmus are thought to result from immunologically mediated mechanisms, with intestinal malabsorption resulting in epistaxis. Conclusions: Celiac disease can cause extraintestinal ENT manifestations and requires a high index of suspicion from the otolaryngologist to diagnose and suitably manage. A gluten-free diet may result in sufficient symptom resolution for most manifestations. Sensorineural hearing loss due to celiac disease appears to be progressive and permanent and may require frequent audiological monitoring.

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Section: Discussionmentioning

confidence: 61%

Section: Hearing Lossmentioning

confidence: 69%

Section: Hearing Lossmentioning

confidence: 99%

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ENT Manifestations of Celiac Disease: A Scholarly Review

Karunaratne

2020

Ear Nose Throat J

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“…Subsequent investigations on associations between CeD and SNHL, including one study on adult patients and eight studies on children and adolescents, were summarized in a systematic review presented by De Luca et al [51]. Another study suggest that hearing screenings should be recommended for children with CD in order to prevent the potentially unfavorable effects of hearing loss on the emotional, behavioral, cognitive, and sensorimotor development of these patients [53]. The presented outcomes were partly contradictory, and an unambiguous close relation between both disorders could not be deduced.…”

Section: Sensorineural Hearing Lossmentioning

confidence: 99%

Otorhinolaryngological Manifestations and Esophageal Disorders in Celiac Disease: A Narrative Review

Wieser,

Ciacci,

Gizzi

et al. 2023

JCM

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Celiac disease (CeD) is a chronic gluten-sensitive immune-mediated enteropathy characterized by numerous intestinal and extra-intestinal signs and symptoms. Among extra-intestinal manifestations, otorhinolaryngological (ORL) complaints in CeD are relatively rare and their relation to CeD is frequently overlooked by physicians. Recent studies underlined that the prevalence of recurrent aphthous stomatitis, aphthous ulcers, geographic tongue, and xerostomia was significantly increased in CeD patients compared with healthy individuals. However, data about the other oral manifestations of CeD, such as atrophic glossitis, glossodynia, angular cheilitis, and salivary abnormalities, are scanty. Further ORL conditions associated with CeD include sensorineural hearing loss, nasal abnormalities, and obstructive sleep apnea. Moreover, several esophageal disorders such as gastroesophageal reflux disease and eosinophilic esophagitis have been associated with CeD. The pathophysiological link between both ORL and esophageal manifestations and CeD might be further investigated. In addition, also the role of gluten-free diet in improving these conditions is largely unclear. Certainly, otorhinolaryngologists can play an important role in identifying people with unrecognized CeD and may help prevent its long-term complications. The aim of this narrative review is to analyze the latest evidence on the association between CeD and ORL and esophageal manifestations.

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“…On the contrary, Bukulmez et al 13 observed similar hearing functions of children with newly diagnosed CD and healthy controls. Other studies from Urgnaci et al 14 Sahin et al 15 Yazici et al 16 and Yaprak et al 17 did not show significant SNHL in overall measurements of patients with CD compared with controls and hypothesized that subclinical SNHL should be investigated in CD patients for recognizing hearing loss early during the course of the disease.…”

mentioning

confidence: 94%

Immune-Mediated Association Between Celiac Disease and Sensorineural Hearing Loss: A Systematic Narrative Review

Luca

Scarpa

Ralli

et al. 2022

Turk J Gastroenterol

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The auto-immune correlation between sensorineural hearing loss and celiac disease has previously been hypothesized. This review describes available evidence and offers insights for future perspectives. We searched the PubMed database. Studies in the review included children and adults with celiac disease evaluated for hearing loss. Individual case reports and review articles were excluded. The various searches turned in 32 results, of which 10 met the inclusion criteria. Auto-immune hearing loss has been proposed as extraintestinal symptoms of celiac disease, despite the pathogenetic mechanisms being not entirely clear. Several studies postulated that subclinical hearing loss may be present in children with celiac disease. Despite existing literature not clarifying the link between celiac disease and sensorineural hearing loss, some authors proposed hearing screening in younger patients with celiac disease, to prevent the behavioral, cognitive, and sensorimotor impairment of hearing loss. Further rigorous studies are strongly recommended to better explore the relationship between hearing loss and celiac disease.

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Evaluation of hearing loss in pediatric celiac patients

Cited by 11 publications

References 31 publications

ENT Manifestations of Celiac Disease: A Scholarly Review

ENT Manifestations of Celiac Disease: A Scholarly Review

Otorhinolaryngological Manifestations and Esophageal Disorders in Celiac Disease: A Narrative Review

Immune-Mediated Association Between Celiac Disease and Sensorineural Hearing Loss: A Systematic Narrative Review

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