Evaluation of hematological changes in population exposed to fluoride

Abstract

Absorption of fluorine compounds produces chronic toxicity and the hematological changes appear earlier in blood than other organs. A study was undertaken to determine the status of hematological changes in the individual residing in fluoride-contaminated area. Two hundred and fifty nine and 233 subjects from the contaminated area and an unaffected area, respectively, were selected for hematological investigations. Total erythrocytes (red blood corpuscles (RBC)), total leucocytes (white blood corpuscles (WBC)), and hemoglobin (Hb) concentrations were determined in these populations. Results revealed that Hb values were significantly lower among all age groups in the exposed population compared to control subjects. There was a quantitative rise in WBC counts in study subjects compared to controls. The RBC counts showed reduction among exposed population.

Effect of Resveratrol on Hematological and Biochemical Alterations in Rats Exposed to Fluoride

“…In addition, as a site of very active metabolism, the liver is especially susceptible to fluoride toxicity [ 7 ]. However, it has been reported that changes due to fluoride exposure occur earlier in blood compared to other tissues and organs [ 8 ]. Previous studies revealed that fluoride had unfavorable effects on hematological and biochemical parameters [ 9 , 10 ] in rats [ 11 , 12 ], mice [ 13 – 15 ], sheep [ 16 ], rabbits [ 17 , 18 ], dogs [ 19 ], camels [ 20 ], and humans [ 8 , 21 ].…”

Environmental and health assessment of soil pollution impact on public health

“…Numerous foreign and domestic studies have shown the relationship between public health status and environmental pollution level [8,16,[18][19][20][21][22][23][24][25][26].…”

Cardioprotective effects of the garlic (Allium sativum) in sodium fluoride-treated rats

“…The animals exposed to fluoride chronically have significantly high levels of both fluoride and calcium in the aorta (Tuncel, 1984) and the heart (Susheela & Kharb, 1990), while acute fluoride intoxication leads to the progressive fall in arterial blood pressure causing cardiovascular damage (Strubelt, Iven, & Younes, 1982), and the prolonged ingestion of fluoride may directly induce histopathological and biochemical changes in myocardial tissue (Cicek, Aydin, Akdogan, & Okutan, 2005). The previous studies proved that fluoride had contrary effects on hematological and biochemical parameters in rats (Agha, El-Badry, Hassan, & Abd Elraouf, 2012) and humans (Ravichandran, Chattopadhyay, Gangopadhyay, & Saiyed, 2012). Also, other studies have reported that cardiac failure patients have high levels of fluoride in the blood.…”