Evaluation of hepatitis B vaccine responsiveness in hemodialysis and peritoneal dialysis patients

Farag, Salama Elsayed; Ghonemy, Tarek A; Soliman, S. S.; Bihery, Ahmed

doi:10.18203/2320-6012.ijrms20150613

Cited by 2 publications

(5 citation statements)

References 14 publications

(14 reference statements)

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“…In this study, there were no differences in the rate of the response to the HB vaccine in terms of the participants' age, while most studies report an association between older ages and an impaired immune response to the HB vaccine [13,15,[18][19][20]. In some other reviews, similar to the present one, no relationship of this type has been reported [1,3]. The reduction in the response to vaccination in older ages could stem from a change in the immune system in older ages due to thymus problems and decreased T cell functionality [21].…”

Section: Discussionsupporting

confidence: 41%

“…There was no association between gender and the rate of the response to the HB vaccine. Different results have been reported for the relationship between these two variables in various studies, with positive correlations reported in some studies [9,[15][16][17] and negative correlations in some others [1,3]. These differences could be explained by intrinsic differences between men and women in their ability to respond to superficial hepatitis antigens.…”

Section: Discussionmentioning

confidence: 85%

“…The results of this study showed no association between the rate of the response to the HB vaccine and T2DM, HTN, as well as renal transplantation among participants. There are controversial findings in similar studies about the relationship between these variables, especially between T2DM and the response to the HB vaccine [1,13,16,17]. There are some hypotheses about the impaired response to the HB vaccine in diabetic persons, which include a reduction in the number of circulating helper T cells, the CD4-to-CD8 lymphocyte ratio, lymphocyte blastogenesis, and the presence of DR3, DR7, and DQ2 human leukocyte antigen alleles in diabetic people [22].…”

Section: Discussionmentioning

confidence: 99%

“…The hepatitis B (HB) virus is a global public health problem that is considered a major cause of cirrhosis and liver cancer [1]. A total of 240 million people have a chronic HB infection worldwide, which results in approximately 780,000 deaths per year from the HB infection, 650,000 deaths from cirrhosis and liver cancer due to the chronic HB infection, and another 130,000 deaths from an acute HB infection.…”

Section: Introductionmentioning

confidence: 99%

“…Despite the completion of their vaccination schedule, they have lower seroconversion rates, lower protective antibody levels, and shorter seroprotection durations [6][7][8]. While the rate of the response to the HB vaccine is 90% among healthy people, it is 50-70% among HD patients [1,9]. The reasons for high susceptibility to HBV among HD patients include invasive medical HD procedures, increased exposure to blood product transfusions, shared machines and equipment, and high prevalence of HBV among HD patients [7,10].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

An Investigation of the Immune Response to Hepatitis B Vaccination in Hemodialysis Patients at Dialysis Centers of Tehran (2016)

Hatami

Movafagh

Ramezankhani

2019

JOHE

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Article Info Background: Hemodialysis (HD) patients are at an increased risk of acquiring the hepatitis B (HB) virus and having lower protective antibody levels as well as shorter durations of seroprotection. This study aims to determine the immune response of HB vaccination in HD patients referring to dialysis centers of the Tehran North Health Network. Materials and Methods: This descriptive study was conducted among all HD patients who referred to dialysis centers of the Tehran North Health Network in 2016. A total of 304 HD patients were included in this study using the census sampling method. Data were collected using a checklist, and the HBsAb level was evaluated by the ELISA test. The collected data were analyzed using analytical tests, including a chi-square test and the independent t-test. Results: The mean±sd values of the serum level of HBsAb were 90.44±97.51 and 105.73±100 IU/L in men and women, respectively. There was no association between the rate of the response to the HB vaccine and gender (P=0.82), age (P=0.13), weight (P=0.09), vaccine injection frequency (P=0.45), number of dialysis sessions/week (P=0.36), and blood type (P=0.97). In addition, there was no association between the response to the HB vaccine and the history of T2DM, HTN, renal transplantation, and cigarette smoking among the participants (P>0.05). Conclusion: One could conclude that the dialysis duration and the last injection of the HB vaccine would have a negative effect on the immune response rate among HD patients.

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