Evaluation of hepatoprotective activity of Allium sativum ethanolic extract in thioacetamide induced hepato-toxicity in albino Wistar rats.

Chinnala, Krishna Mohan; Jayagar, Praisy Pinky; Motta, Gayathri; Adusumilli, Raghuma Chowdary; Elsani, Madhan Mohan

doi:10.5455/ajrms.20180107060815

Cited by 7 publications

(5 citation statements)

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“…Considering these findings, Lin seems to be safe for use in rats and to exert hepatoprotective effects against CCl 4 ‐induced liver damage. Similar hepatoprotective effects were reported in the literature for Phaleria macrocarpa (Proliverenol) water extract against CCl 4 ‐induced hepatotoxicity 37 and for Allium sativum ethanolic extract against thioacetamide‐induced hepatotoxicity 38 …”

Section: Discussionsupporting

confidence: 83%

“…Similar hepatoprotective effects were reported in the literature for Phaleria macrocarpa (Proliverenol) water extract against CCl 4induced hepatotoxicity 37 and for Allium sativum ethanolic extract against thioacetamide-induced hepatotoxicity. 38 Inflammation is associated with the pathogenesis of hepatic fibrogenesis and chronic liver disease. 39 Cirrhosis begins as compensated cirrhosis and develops into an advanced stage characterized by chronic liver failure.…”

Section: Discussionmentioning

confidence: 99%

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Immunomodulatory effect of Linalool (Lin) against CCl₄‐induced hepatotoxicity and oxidative damage in rats

Hsouna

Sadaka

Beyrouthy

et al. 2022

Biotech and App Biochem

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The current study explored the hepatoprotective and immunomodulatory effects of Linalool (Lin) against carbon tetrachloride (CCl4)‐induced toxicity in mice. Four study groups (n = 8 each) were used: (1) a negative control group and (2) a toxicity control group (single dose of CCl4 administered on day 14 as 1 mL/kg of CCL4 in 1% olive oil). Intraperitoneally (i.p.)), and two experimental groups where mice were treated with either (3) Lin (25 mg/kg b.w., orally, daily for 15 days) or (4) pretreated with Lin (25 mg/kg b.w., orally, daily for 14 days) and intoxicated with CCl4 (1 mL/kg of CCL4 in 1% olive oil. i.p.) on day 14. The levels of the anti‐inflammatory cytokine interleukin 10 (IL‐10), the proinflammatory cytokines TNF‐α, IL‐6, and TGF‐1β, and the histopathology of the liver were assessed. According to our findings, IL‐10 concentrations were significantly increased in Lin‐treated groups, while other cytokine levels were marked by a considerable decrease in the toxicity model group (CCl4‐treated group). Histopathological examinations of liver tissues showed that the Lin‐treated groups had an almost normal structure. The current findings showed that Lin could inhibit CCl4‐induced liver injury in mice, which warrants further investigation of Lin as a potential protective and therapeutic agent against hepatotoxicity.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Immunomodulatory effect of Linalool (Lin) against CCl₄‐induced hepatotoxicity and oxidative damage in rats

Hsouna

Sadaka

Beyrouthy

et al. 2022

Biotech and App Biochem

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“…Also, The LVX induced hepatotoxicity (Schloss et al, 2018). However, lower values were obtained in the combined treated group which could be attributed to A. sativum hepatoprotective effect (Chinnala et al, 2018;Guan et al, 2018).…”

Section: Discussionmentioning

confidence: 90%

Efficacy of Topoisomerase Inhibitor Ii (Levofloxacin) Combined With Allium Sativum on Experimental Cerebral Toxoplasmosis Infected Mice

Beshay

Atia

Dawoud

et al. 2023

Journal of the Egyptian Society of Parasitology

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Toxoplasmosis is a worldwide parasitic disease that affects about one third of the population. The infection may range from asymptomatic to severe deadly in immunocompromised patients. Unfortunately, the available drugs are toxic and cannot eradicate bradyzoites in chronic disease. The study evaluated levofloxacin combined with Allium sativum compared with trimethoprim + sulphamethoxazole to treat experimental cerebral toxoplasmosis in mice infected with Me49 cystogenic strain. The study included normal control group (GI), infected control group (GII), levofloxacin-treated group (GIII) (90 mg/kg/day starting on the 4 th d.p.i. and continued for 7 days), Sutrim-treated group (GIV) (Trimethoprim at a dose 30 mg/kg/day + Sulphamethoxazole at a dose of 150 mg/kg/day starting on 4 th d.p.i and continued for 30 days), and the combined LVX+A. sativum-treated (GV) (LVX was given as described in GIII and A. sativum was given at a dose of 500mg/kg/day started on the 4 th d.p.i up to 30 days). The experiment was terminated on the 45 th d.p.i. Giemsa-stained impression smears from brain tissues of each mouse were prepared to determine parasitic load. Histopathological and immunohistochemical studies were done. Serum samples were prepared for immunological (IL-10, IL-12, IL-17, IFN-) and biochemical studies (iNOS, AST, ALT, urea, creatinine). The best results were obtained in GV, with a significant reduction (92.77%) in brain cyst count with improved histopathological findings. There was a significant decrease in IL-10 and significant increases in IL-12, IL-17, IFN-, iNOS. Liver and renal functions biochemical studies showed safety of this combination.

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“…These result are similar to the result of Sundari et al (2018) who reported that after treatment with water extract of Phaleria macrocarpa (Proliverenol) against CCl4‐Induced liver fibrosis in experimental rats, ALT and AST were significantly decreased. Also Chinnala et al (2018) found that serum ALT, AST, and ALP levels were significantly decreased by administration of ethanolic extract of Allium sativum (EEAS) on thioacetamide (TAA)‐induced hepatotoxicity in rats at 200 and 400 mg/kg. These results displayed that curcumin protect the liver from fibrosis and also suppressed inflammation caused by CCl4.…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory effect of curcumin on hepatic cirrhosis in experimental rats

2020

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Cirrhosis is a chronic liver disease. The present work aimed to evaluate the regulatory immune effect of curcumin in hepatic cirrhosis induced by carbon tetrachloride (CCl4) injections in experimental rats’ model. Chronic liver fibrosis was induced in experiment animals by recurrent injections of CCl4 for more than 5 weeks. They were divided into five groups: first group was injected with normal saline, second group with CCl4, third, fourth, and fifth groups were injected with CCl4 (intraperitoneal injection) at dose 3 ml/kg, two times weekly for 6 weeks supplemented with the administration of curcumin with concentrations 250, 200, and 150 mg/kg. Immune response was analyzed to different treatments. Interleukin 10 (IL‐10), pro‐inflammatory cytokines TNF‐α, TGF‐1β, and liver histopathological examinations were conducted. The results showed that estimations of IL‐10 concentrations were significantly increased in curcumin groups compared with CCl4 group, whereas TNF‐α and TGF‐1β levels were significantly decreased comparing with CCl4 group. The histopathological examinations for liver tissues showed that curcumin treated groups have almost retained the normal structure of liver tissues. In conclusion, curcumin inhibited hepatic fibrosis and liver fibrogenesis with regulation of the immune system mechanism against invader chemical toxicity. Practical applications Curcumin is well documented for its medicinal properties, commonly used as a spice. Our work has thus demonstrated its effectiveness as an immunomodulatory agent. Practically, clinical studies have suggested that curcumin displays a diverse and powerful array of pharmacological effects in nearly all of the human body's major organ systems. These are: antidiabetes, anti‐inflammatory, anticancer, antiaging, antioxidant, antibacterial infection, hepatoprotective, neurodegenerative, and cardiovascular effects.

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Evaluation of hepatoprotective activity of Allium sativum ethanolic extract in thioacetamide induced hepato-toxicity in albino Wistar rats.

Cited by 7 publications

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Immunomodulatory effect of Linalool (Lin) against CCl₄‐induced hepatotoxicity and oxidative damage in rats

Immunomodulatory effect of Linalool (Lin) against CCl₄‐induced hepatotoxicity and oxidative damage in rats

Efficacy of Topoisomerase Inhibitor Ii (Levofloxacin) Combined With Allium Sativum on Experimental Cerebral Toxoplasmosis Infected Mice

Immunomodulatory effect of curcumin on hepatic cirrhosis in experimental rats

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Evaluation of hepatoprotective activity of Allium sativum ethanolic extract in thioacetamide induced hepato-toxicity in albino Wistar rats.

Cited by 7 publications

References 0 publications

Immunomodulatory effect of Linalool (Lin) against CCl4‐induced hepatotoxicity and oxidative damage in rats

Immunomodulatory effect of Linalool (Lin) against CCl4‐induced hepatotoxicity and oxidative damage in rats

Efficacy of Topoisomerase Inhibitor Ii (Levofloxacin) Combined With Allium Sativum on Experimental Cerebral Toxoplasmosis Infected Mice

Immunomodulatory effect of curcumin on hepatic cirrhosis in experimental rats

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Immunomodulatory effect of Linalool (Lin) against CCl₄‐induced hepatotoxicity and oxidative damage in rats

Immunomodulatory effect of Linalool (Lin) against CCl₄‐induced hepatotoxicity and oxidative damage in rats