Evaluation of Hesperidin Protective Effect on Lipopolysaccharide-Induced Inflammation and Lipid Peroxidation in BALB/c male mice

Al-Rikabi, Rasha H.; Al-Shmgani, Hanady S.

doi:10.5958/0974-360x.2018.00978.2

Cited by 5 publications

(3 citation statements)

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“…The increase in the production of free radicals causing fat oxidation loses cell membranes, which is an important cause of destruction and damage to the cell membrane [19]. Our previous study [20], demonstrated that the liver is a target of LPS oxidative damage, which led to a significant increase in malondialdehyed (MDA) in the homogenate mice liver as a marker of lipid peroxidation. Similarly, Kaur et al [17] reported the improvement of hesperidin in (LPS) endotoxin-induced hepatotoxicity and oxidative stress in the liver of rats; suggested mechanisms by inhibition of cytotoxic effect of nitric oxide and free radicals ROS in particular..…”

Section: Discussionmentioning

confidence: 99%

In Vivo and In Vitro Evaluation of the Protective Effects of Hesperidin in Lipopolysaccharide-Induced Inflammation and Cytotoxicity of Cell

et al. 2020

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(1) Background: Plant flavonoids are efficient in preventing and treating various diseases. This study aimed to evaluate the ability of hesperidin, a flavonoid found in citrus fruits, in inhibiting lipopolysaccharide (LPS) induced inflammation, which induced lethal toxicity in vivo, and to evaluate its importance as an antitumor agent in breast cancer. The in vivo experiments revealed the protective effects of hesperidin against the negative LPS effects on the liver and spleen of male mice. (2) Methods: In the liver, the antioxidant activity was measured by estimating the concentration of glutathione (GSH) and catalase (CAT), whereas in spleen, the concentration of cytokines including IL-33 and TNF-α was measured. The in vitro experiments including MTT assay, clonogenity test, and sulforhodamine 101 stain with DAPI (4′, 6-diamidino-2-phenylindole) were used to assess the morphological apoptosis in breast cancer cells. (3) Results: The results of this study revealed a significant increase in the IL-33 and TNF-α cytokine levels in LPS challenged mice along with a considerable elevation in glutathione (GSH); moreover, the catalase (CAT) level was higher compared to that of the control group. Cytotoxicity of the MCF-7 cell line revealed significant differences among the groups treated with different concentrations when compared to the control groups, in a concentration-dependent manner. Hesperidin significantly inhibited the colony formation of MCF7 cells when compared to that of control. Clear changes were observed in the cell shape, including cell shrinkage and chromatin condensation, which were associated with a later apoptotic stage. (4) Conclusion: The results indicate that hesperidin might be a potential candidate in preventing diseases.

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Section: Discussionmentioning

confidence: 99%

In Vivo and In Vitro Evaluation of the Protective Effects of Hesperidin in Lipopolysaccharide-Induced Inflammation and Cytotoxicity of Cell

et al. 2020

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“…[12][13][14] LiI has become an established additive for performance enhancement in various battery systems, [15][16][17][18][19] and a number of fundamental studies helped to understand its role as an additive. [20][21][22][23][24][25] Lithium thiocyanate (often referred to as a pseudo-halide) is chemically and structurally similar to lithium iodide, since they both have a large polarizable anion, 26,27 are hygroscopic and form hydrates. [28][29][30][31] However, in contrast to LiI and other halides, little is known about the defect chemistry of Li(SCN).…”

Section: Introductionmentioning

confidence: 99%

Ion transport mechanism in anhydrous lithium thiocyanate LiSCN Part I: ionic conductivity and defect chemistry

Joos

Conrad

Rad

et al. 2022

Phys. Chem. Chem. Phys.

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“…Flavonoids are very potent in quenching free radicals and reduce their production. Hesperidin (HSP) is a glycoside flavone found mainly in citrus fruit peel, with diverse pharmacology activities including prostaglandin-synthesis inhibition, antioxidant, antiinflammatory, and anticancer effects [3][4][5]. HSP and maybe other natural flavonoids have lower water solubility and slight lipophilic molecules to effectively enter membrane [6,7].…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, Docking, Antitumor Screening, and Absorption, Distribution, Metabolism, and Excretion Prediction of New Hesperdin Derivative

Al-Shmgani

Shakir

Naser

et al. 2019

Asian J Pharm Clin Res

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Objective: Hesperidin (HSP) is a pharmacologically active organic compound found in citrus fruits and peppermint. We synthesized a new HSP derivative by reacting it with 5-Amino-1,3,4-thiadiazole-2-thiol in acetic acid. Methods: This compound was characterized by Fourier-transform infrared, proton nuclear magnetic resonance, and electron impact mass spectra. A molecular docking study explores the predicted binding of the compound and its possible mode of action. Bioavailability, site of absorption, drug mimic, and topological polar surface was predicted using absorption, distribution, metabolism, and excretion (ADME) studies. Results: The docking study predicts that the new compound binds to the active sites of Aurora-B and the MST3 pocket and has good ADME properties. Moreover, the thiazole ring and the presence of the electron releasing groups and hydrogen bond interaction with amino acid residues within the active sites play an important role in enhancing the antioxidant activity. Conclusion: In the present study, a new HSP derivative has been synthesized and characterized successfully and a theoretically promising antioxidant and anticytotoxic active agent introduced. We have shown the detailed binding analysis of 1,3,4-thiadiazol and hydrogen bonds with the inhibitor binding cavity of Aurora B and MST3. This could provide the development of some effective compounds against different diseases.

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Evaluation of Hesperidin Protective Effect on Lipopolysaccharide-Induced Inflammation and Lipid Peroxidation in BALB/c male mice

Cited by 5 publications

References 0 publications

In Vivo and In Vitro Evaluation of the Protective Effects of Hesperidin in Lipopolysaccharide-Induced Inflammation and Cytotoxicity of Cell

In Vivo and In Vitro Evaluation of the Protective Effects of Hesperidin in Lipopolysaccharide-Induced Inflammation and Cytotoxicity of Cell

Ion transport mechanism in anhydrous lithium thiocyanate LiSCN Part I: ionic conductivity and defect chemistry

Design, Synthesis, Docking, Antitumor Screening, and Absorption, Distribution, Metabolism, and Excretion Prediction of New Hesperdin Derivative

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