Evaluation of histopathology of cervix in women with unhealthy cervix

Abstract

Background: Carcinoma of cervix is the third most common cancer in women worldwide and most common female cancer in India. Most cervical cancers can be detected at pre-invasive state with an adequate screening and treated, preventing overt progression to invasive cancer and hence decreasing morbidity and mortality. This study was conducted to evaluate the histopathological diagnosis of cervix biopsy in unhealthy cervix and to determine the incidence of the various precancerous and cancerous lesions.Methods: It was a prospective study in the department of Obstetrics and Gynecology in a tertiary care hospital over a period of two years. 802 women with unhealthy cervix were included in the study. Punch biopsy was taken from the cervix and sent for histopathological examination.Results: Total of 802 women were included in the study. They were in the age group of 26-75years. 53.4% were in the age group of 40-49 years followed by 20% in the age group of 30-39 years. The most common finding was chronic cervicitis in 89.4% followed by CIN I in 4.1%, CIN II in 0.9% of patients, squamous cell carcinoma in 2.1% and endocervical carcinoma in 0.4%.Conclusions: Cancer cervix is an ideal malignancy for screening, can be detected early and the premalignant lesion can be treated to prevent the progress to invasive disease. Hence all women with unhealthy cervix should be subjected to punch biopsy to detect early cases of cancer & carcinoma in situ.

A comparative study of Pap smear and colposcopy guided biopsy in the evaluation of unhealthy cervix

“…1,3,6 In the studies done by Vincent et al and Sathiyakala et al, 26.5% women and 20% women belonged to the same age group, respectively. 4,8 The findings in their studies could be different from the present study because their study sample was more compared to this study.…”

“…2 Cervical cancer is a malignancy that has got a long latent period to transform into invasive carcinoma, so if women undergo screening at an early stage of disease, invasive lesion of cervix can be prevented. 8 More than 80% of women with cervical carcinoma present with advanced stage of disease, due to their lack of health education, awareness of screening programs and lack of accessibility to medical services. 9 The most common type of carcinoma of cervix is squamous cell carcinoma.…”

Clinicopathological Study of Carcinoma Cervix in a Tertiary Care Centre

“…14,15,16,17 In our study, out of 152 cases of carcinoma cervix, 149 (98.03%) were squamous cell carcinoma, which was higher than the studies by Rajendiran S et al (85%), Bodal V K et al (85.18%) and Ikram et al (83.33%). 11,12,18 In our study, the incidence of adenocarcinoma was 1.97%, whereas Rajendiran S et al and Bodal VK et al reported the incidence of adenocarcinoma as 0.4% and 2%, respectively. 11,12 Reagan et al subdivided squamous cancer of the cervix into-(a) Large cell keratinising carcinoma; (b) Large cell non-keratinising carcinoma; and (c) Small cell nonkeratinising carcinoma.…”

“…11,12,18 In our study, the incidence of adenocarcinoma was 1.97%, whereas Rajendiran S et al and Bodal VK et al reported the incidence of adenocarcinoma as 0.4% and 2%, respectively. 11,12 Reagan et al subdivided squamous cancer of the cervix into-(a) Large cell keratinising carcinoma; (b) Large cell non-keratinising carcinoma; and (c) Small cell nonkeratinising carcinoma. The distinction between large-cell keratinising and non-keratinising squamous cell carcinoma is based primarily on the presence of intercellular bridges and keratin pearls in the former, although focal individual cell keratinisation maybe present in the latter.…”

“…10 In the present study, 50 (32.9%) cases were in the age group of 51-60 years followed by 46 (30.26%) cases in the age group of 41-50 years, while study by Rajendiran S et al showed maximum number of cases in 40-49 years (53.4%) age group. 11 Bodal VK et al found maximum number of patients were in the fourth decade of life followed by fifth decade. 12 Rathoda GB et al found most patients were in the age group of 41-50 years (42.4%) followed by age group 51-60 years.…”