Evaluation of HSP70, 27 and TNF-α espression in different canine cutaneous and gland diseases

Monari, Marta; Foschi, Jurgen; Forteguerri, Elena Bichi Ruspoli; Valgimigli, Simond; Zanatta, Marco; Capitani, Ombretta; Serrazanetti, Gian Paolo

doi:10.1007/s11259-009-9302-8

Cited by 1 publication

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“…In humans, HSPA1 is weakly expressed in the epidermis under physiological conditions, but its level can be elevated in pathological conditions (well-examined in tumor cases) 12 . It has also been reported that HSP70 is upregulated in canine cutaneous tumors and tumor-like regions 13 . In the present case, severe inflammation was observed in the ceruminous glands.…”

Section: Intranuclear Inclusion Bodies Are Categorized As Viralmentioning

confidence: 93%

Chronic otitis externa with heat shock protein 70-positive intranuclear inclusion bodies in the ceruminous gland epithelium of a Chihuahua dog

et al. 2022

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A Chihuahua dog showed persistent itching in the right ear canal. Anti-inflammatory medicines and prednisolone were ineffective and total ear canal ablation was performed. Histological diagnosis was chronic otitis externa. Eosinophilic intranuclear inclusion bodies (Cowdry type A and full-type) were occasionally observed in the ceruminous gland epithelium. The inclusion bodies were negative for nucleic acid and ultrastructurally composed of fibrous structures (approximately 10 nm in width). Viral infection was initially suspected, but polymelase chain reaction tests did not detect the expected viral genes. Immunohistochemistry revealed that the inclusion bodies were positive for heat shock protein 70 (HSP70), suggesting that these bodies could be protein aggregates including HSP70. The etiology of this lesion has not been elucidated, but chronic inflammation may influence the cytoplasm-to-nuclear transportation of HSP70. To the best of our knowledge, this is the first report of canine chronic otitis externa with HSP70-positive intranuclear inclusion bodies.

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Section: Intranuclear Inclusion Bodies Are Categorized As Viralmentioning

confidence: 93%